Públic vs. privat - Reflexions al voltant de l’espai

[cat] La pandèmia ha portat canvis en la manera de viure i relacionar-nos amb els altres. Han canviat la manera d’entendre l’espai públic i l’espai privat, transformant-los d’una manera radical. Hem hagut d’adaptar els espais i la ciutat a la nova realitat. Durant el confinament, l’espai públic va quedar buit i abandonat, i vàrem haver d’adaptar l’espai privat a un que complia la funció d’altres espais (oficina, escola, universitat, taller, gimnàs, biblioteca, plaça, etc.). Això ha posat de manifest la desigualtat social, la precarietat de l’habitatge i la urgència climàtica. L’espai privat, que moltes vegades era un lloc de trànsit, ha passat a ser un espai on hi passem moltes hores. La pandèmia ens ha fet reflexionar sobre com vivíem, com consumíem (comerç de proximitat) i el medi ambient fent-nos repensar els espais. Alhora, hem evidenciat l’impacte positiu en el medi ambient fruit de l’aturada de l’activitat humana desfermada que implica el sistema productiu i de consum. El projecte pretén visibilitzar aquestes reflexions mitjançant projectes que tractin aquestes qüestions i desenvolupin propostes que interpel.lin a la ciutadania. Professorat i alumnat de la Facultat de Belles Arts (UB) desenvolupen projectes en clau d’Aprenentatge Servei per reflexionar sobre aquestes qüestions. Les jornades reuneixen professorat, artistes i professionals del sector que desenvolupen projectes de pedagogia comunitària en art i sostenibilitat. Ponències, presentacions i taules rodones de manera virtual i presencial al centre del Barri Gòtic.[spa] La pandemia ha traído cambios en la forma de vivir y relacionarnos con los demás. La forma de entender el espacio público y privado ha cambiado, transformándose de una forma radical. Hemos tenido que adaptar los espacios y la ciudad a la nueva realidad. Durante el confinamiento, el espacio público quedó vacío y abandonado, y tuvimos que adaptar el espacio privado a uno que cumpliera la función de otros espacios (oficina, escuela, universidad, taller, gimnasio, biblioteca, plaza, etc.). Esto ha puesto en relieve la desigualdad social, la precariedad de las viviendas y la urgencia climática. El espacio privado, que a menudo era un espacio de tránsito, ha pasado a ser un espacio al que le dedicamos muchas horas. La Pandemia nos ha hecho reflexionar sobre cómo vivíamos, cómo consumíamos (comercio de proximidad) y el medio ambiente, obligándonos a replantear los espacios. A la vez, hemos constatado el impacto positivo en el medio ambiente fruto del parón de la actividad humana desenfrenada que implica nuestro sistema productivo y de consumo. Este proyecto pretende visibilizar estas reflexiones mediante proyectos que traten estas cuestiones y desarrollen propuestas que interpelen a la ciudadanía. Profesorado y alumnado de la Facultat de Belles Arts (UB) desarrollan proyectos en clave de Aprendizaje-Servicio para reflexionar sobre estas cuestiones. Las jornadas reúnen profesorado, artistas y profesionales del sector que desarrollan proyectos de pedagogía comunitaria en arte y sostenibilidad. Ponencias, presentaciones y mesas redondas de manera virtual y presencial en el centro del Barrio Gótico

Treure pols de sota l'aigua

[cat] Des del plantejament metodològic de l’Aprenentatge Servei, que fomenta una participació activa en la societat i en els entorns educatius, els membres del Grup ApS–UB de la Facultat s’han bolcat en potenciar distintes accions incloses en el programa del festival (performance, escultura, intervencions en l’espai, disseny de vestuari, workshops) que busquen explícitament la participació i la interacció amb el públic. Els/les artistes (estudiants/es) promouen la cooperació cívica i la consciència ecològica per a un món més sostenible en un espai bioconstruït pel col·lectiu Investigació Canyera. La recreació d’uns personatges tradicionals, els «cigarreros», amb reminiscències del mitològic «Oannes»; la construcció amb xarxes de pesca descartades; la creació de nanses que poden capturar persones; la fabricació de peixos amb materials de rebuig; la realització de sorteigs de troballes en una tómbola inusual; el treball amb l’art sonor i lumínic com a forma d’alterar la realitat... propostes que parteixen del treball sobre la contaminació marina i les problemàtiques que hi naveguen. Una temàtica que parteix de la invitació dels artistes Thomas Nölle i Claudia Giannetti a col·laborar en el projecte artístic Sea-Store; de la gestió de Tanja Grass, directora del Festival Drap Art; de Manuel Aramendía, vicedegà de cultura de la Facultat de Belles Arts de la Universitat de Barcelona; i del suport del projecte Marviva (Agència de Residus de Catalunya, Confraria de Pescadors de Barcelona i Autoritat Portuària de Barcelona).[spa] Desde el planteamiento metodológico del Aprendizaje-Servicio, que fomenta una participación activa en la sociedad y en los entornos educativos, los miembros del Grupo ApS–UB de la Facultad se han volcado en potenciar distintas acciones incluidas en el programa del festival (performance, escultura, intervenciones en el espacio, diseño de vestuario, workshops) que buscan explícitamente la participación y la interacción con el público. Los/las artistas(estudiantes) promueven la cooperación cívica y la conciencia ecológica para un mundo más sostenible en un espacio bioconstruido por el colectivo Investigación Cañera. La recreación de unos personajes tradicionales, los «cigarreros», con reminiscencias del mitológico «Oannes»; la construcción con redes de pesca descartadas; la creación de nasas que pueden capturar personas; la fabricación de peces con materiales de rechazo; la realización de sorteos de hallazgos en una tómbola inusual; el trabajo con el arte sonoro y lumínico como forma de alterar la realidad... propuestas que parten del trabajo sobre la contaminación marina y las problemáticas que la navegan. Una temática que parte de la invitación de los artistas Thomas Nölle y Claudia Giannetti a colaborar en el proyecto artístico Sea-Store; de la gestión de Tanja Grass, directora del Festival Drap Art; de Manuel Aramendía, vicedecano de cultura de la Facultad de Bellas Artes de la Universitat de Barcelona; y del apoyo del proyecto Marviva (Agencia de Residuos de Cataluña, Cofradía de Pescadores de Barcelona y Autoridad Portuaria de Barcelona)

pT3 colorectal cancer revisited: a multicentric study on the histological depth of invasion in more than 1000 pT3 carcinomas—proposal for a new pT3a/pT3b subclassification

BACKGROUND: Pathological TNM staging (pTNM) is the strongest prognosticator in colorectal carcinoma (CRC) and the foundation of its post-operative clinical management. Tumours that invade pericolic/perirectal adipose tissue generally fall into the pT3 category without further subdivision. METHODS: The histological depth of invasion into the pericolic/perirectal fat was digitally and conventionally measured in a training cohort of 950 CRCs (Munich). We biostatistically calculated the optimal cut-off to stratify pT3 CRCs into novel pT3a (≤3 mm)/pT3b (>3 mm) subgroups, which were then validated in two independent cohorts (447 CRCs, Bayreuth/542 CRCs, Mainz). RESULTS: Compared to pT3a tumours, pT3b CRCs showed significantly worse disease-specific survival, including in pN0 vs pN+ and colonic vs. rectal cancers (DSS: P < 0.001, respectively, pooled analysis of all cohorts). Furthermore, the pT3a/pT3b subclassification remained an independent predictor of survival in multivariate analyses (e.g. DSS: P < 0.001, hazard ratio: 4.41 for pT3b, pooled analysis of all cohorts). While pT2/pT3a CRCs showed similar survival characteristics, pT3b cancers remained a distinct subgroup with dismal survival. DISCUSSION: The delineation of pT3a/pT3b subcategories of CRC based on the histological depth of adipose tissue invasion adds valuable prognostic information to the current pT3 classification and implementation into current staging practices of CRC should be considered

IL-22BP controls the progression of liver metastasis in colorectal cancer

BackgroundThe immune system plays a pivotal role in cancer progression. Interleukin 22 binding protein (IL-22BP), a natural antagonist of the cytokine interleukin 22 (IL-22) has been shown to control the progression of colorectal cancer (CRC). However, the role of IL-22BP in the process of metastasis formation remains unknown.MethodsWe used two different murine in vivo metastasis models using the MC38 and LLC cancer cell lines and studied lung and liver metastasis formation after intracaecal or intrasplenic injection of cancer cells. Furthermore, IL22BP expression was measured in a clinical cohort of CRC patients and correlated with metastatic tumor stages.ResultsOur data indicate that low levels of IL-22BP are associated with advanced (metastatic) tumor stages in colorectal cancer. Using two different murine in vivo models we show that IL-22BP indeed controls the progression of liver but not lung metastasis in mice.ConclusionsWe here demonstrate a crucial role of IL-22BP in controlling metastasis progression. Thus, IL-22 might represent a future therapeutic target against the progression of metastatic CRC

Neonatal transport in Switzerland: a retrospective single-centre analysis - quo vadis?

AIM: To assess neonatal transport activities by the neonatal transport teams of the University Children&rsquo;s Hospital Zurich in order to identify opportunities for improvement in the organisation of these transports. METHODS: Retrospective analysis of prospectively collected data on neonatal transports by the neonatal transport teams of the University Children&rsquo;s Hospital Zurich between January 2014 and December 2018. Data on transports affecting neonates with a corrected gestational age of up to 44 weeks and a weight less than 5 kg were extracted from registration forms, transport forms, transport reports and the neonates&rsquo; medical charts. Transport data were assessed separately for urgent, non-urgent and re-transfers. RESULTS: During the study period, 1110 transport runs, including 883 (79.5%) urgent, 105 (9.5%) non-urgent and 122 (11.0%) re-transfers were performed. Ground transport accounted for 90.7% of the cases. The majority (77.7%) of the transported neonates were born at term and 59.1% were transported within the first 24 hours of life. The most common reason for transport was respiratory distress (39.9%), followed by cardiac diseases (14.6%). Medical procedures performed by the neonatal transport teams during transport mostly addressed peripheral intravenous line placement (41.8%) and feeding tube placement (41.8%). The median preparation time for urgent transfers was 35 min (range 8&ndash;225) for ground and 50 min (range 20&ndash;260) for air transport. CONCLUSIONS: The high proportion of urgent transfers emphasises the need for an efficient neonatal transport system and dedicated neonatal transport teams staffed by members with training in neonatal transport and expertise in handling neonatal emergencies. To provide the best possible care to the vulnerable neonates, the heterogeneous nature of the cohort of transported neonates regarding the diagnoses transport demand was made for and the medical procedures performed during transport should be considered in simulation training of neonatal transport team staff. Additionally, processes to improve preparation time should be defined and implemented in order to reduce it to less than 30 min so as to guarantee efficient care. Further studies are needed to assess the quality and efficacy of neonatal transports in Switzerland. National guidelines on the standard of neonatal transport and quality metrics should be established in order to set benchmarks and to improve the quality of the transports

Neonatal transport in Switzerland: a retrospective single-centre analysis – quo vadis?

AIM To assess neonatal transport activities by the neonatal transport teams of the University Children’s Hospital Zurich in order to identify opportunities for improvement in the organisation of these transports. METHODS Retrospective analysis of prospectively collected data on neonatal transports by the neonatal transport teams of the University Children’s Hospital Zurich between January 2014 and December 2018. Data on transports affecting neonates with a corrected gestational age of up to 44 weeks and a weight less than 5 kg were extracted from registration forms, transport forms, transport reports and the neonates’ medical charts. Transport data were assessed separately for urgent, non-urgent and re-transfers. RESULTS During the study period, 1110 transport runs, including 883 (79.5%) urgent, 105 (9.5%) non-urgent and 122 (11.0%) re-transfers were performed. Ground transport accounted for 90.7% of the cases. The majority (77.7%) of the transported neonates were born at term and 59.1% were transported within the first 24 hours of life. The most common reason for transport was respiratory distress (39.9%), followed by cardiac diseases (14.6%). Medical procedures performed by the neonatal transport teams during transport mostly addressed peripheral intravenous line placement (41.8%) and feeding tube placement (41.8%). The median preparation time for urgent transfers was 35 min (range 8–225) for ground and 50 min (range 20–260) for air transport. CONCLUSIONS The high proportion of urgent transfers emphasises the need for an efficient neonatal transport system and dedicated neonatal transport teams staffed by members with training in neonatal transport and expertise in handling neonatal emergencies. To provide the best possible care to the vulnerable neonates, the heterogeneous nature of the cohort of transported neonates regarding the diagnoses transport demand was made for and the medical procedures performed during transport should be considered in simulation training of neonatal transport team staff. Additionally, processes to improve preparation time should be defined and implemented in order to reduce it to less than 30 min so as to guarantee efficient care. Further studies are needed to assess the quality and efficacy of neonatal transports in Switzerland. National guidelines on the standard of neonatal transport and quality metrics should be established in order to set benchmarks and to improve the quality of the transports

Pressurized Intra Peritoneal Aerosol Chemotherapy in patients suffering from peritoneal carcinomatosis of pancreatic adenocarcinoma

Patients suffering from peritoneal carcinomatosis of pancreatic adenocarcinoma were treated with Pressurized Intra Peritoneal Aerosol Chemotherapy (PIPAC), initial clinical findings are presented.Single institution, tertiary referral center certified for therapy of peritoneal disease. Prospective data collection of PIPAC therapy with doxorubicin 1.5 mg/m2 and cisplatin 7.5 mg/m2 of body surface delivered at intervals of six weeks. The outcome criteria were microscopic pathological response, survival and adverse events (v4.0 CTCAE).A total of 20 patients (m/f = 3:1) with a mean age of 64.9 (range: 45.0 to 87.0) years underwent 41 PIPAC procedures without intraoperative complications. The mean number of PIPAC cycles was 2.1 (range: one to four). Ten patients with ≥ 2 PIPAC applications were eligible for histological analysis to assess carcinoma regression. Complete or high grade tumor regression was found in two (10%) and five (25%) patients, respectively. An overall median survival of 36.6 weeks after the first PIPAC application was observed. One patient died postoperatively due to small bowel obstruction. No CTCAE level 3 and 4 complications occurred.In about one third of patients, repeated PIPAC therapy did induce histological regression of systemic chemo-resistant PC of pancreatic adenocarcinoma. Prospective randomized trials are needed to further clarify any clinical impact of such observations