The mod 2 cohomology rings of congruence subgroups in the Bianchi groups

We provide new tools for the calculation of the torsion in the cohomology of congruence subgroups in the Bianchi groups : An algorithm for finding particularly useful fundamental domains, and an analysis of the equivariant spectral sequence combined with torsion subcomplex reduction.\_\_\_\_\_\_\_\_\_\_With an appendix by Bui Anh Tuan and Sebastian Sch{\"o}nnenbec

The mod 2 cohomology rings of congruence subgroups in the Bianchi groups

We provide new tools for the calculation of the torsion in the cohomology of congruence subgroups in the Bianchi groups : An algorithm for finding particularly useful fundamental domains, and an analysis of the equivariant spectral sequence combined with torsion subcomplex reduction

Functional Performance of Older Adults with Dementia Participating in Adult Day Service Programs

Individuals with dementia are at a high risk of functional decline and falling. The aim of this study was to investigate the possible relationship between cognition and functional performance in older adults with dementia participating in Goodwill Easter Seals adult day service programs. This data may be helpful in understanding how cognition may impact functional performance and fall risk.https://ecommons.udayton.edu/dpt_symposium/1023/thumbnail.jp

Body Fat Percentage and Hormonal Intrauterine Device Use Are Independently Associated with Self-Reported Menstrual Regularity in Young Adult Females

Menstrual regularity is a key indicator of energy availability, long-term bone density, and other important health information in females. The occurrence of a regular menstrual cycle indicates that an individual’s level of estrogen is supportive of strong bones and that they are achieving the caloric intake required to support their activity level. In contrast, an irregular menstrual cycle can be indicative of insufficient energy availability which may, over time, result in low bone mineral density and thus a higher risk of bone stress injuries. However, hormonal contraceptive use, including the rising use of intrauterine devices (IUDs), may mask these changes in menstrual regularity. PURPOSE: The purpose of this study was to examine factors related to self-reported menstrual regularity among a population of young, generally healthy females. METHODS: Participants were included if they were no more than 50 years of age at the time of enrollment and had less than 50% body fat as assessed via dual-energy x-ray absorptiometry (DXA). Participants were asked via questionnaire if they reported having a regular menstrual cycle, defined as menstrual periods occurring at predictable intervals and no missed periods in the past six months. Additionally, participants were asked if they were currently using any form of hormonal contraception, and if so, what type. A logistic regression was run with menstrual regularity (1 = regular; 0 = irregular) as the dependent variable and body fat percentage (BFP) and contraceptive type as the predictors. RESULTS: Out of the 76 participants (mean±SD age: 23.2±5.1 years; height: 164.5±6.5 cm; weight: 65.2±13.6 kg; BFP: 32.3±8.5%), 54 (71%) reported having a regular menstrual cycle. Of the 45 (59%) participants using hormonal contraception, 27 (60%) used a combined oral contraceptive pill, six (13%) used a progestin-only pill, nine (20%) used an IUD, two (4%) used a hormonal implant, and one (2%) used a vaginal ring. Overall, a higher BFP was associated with a greater likelihood of menstrual regularity (coefficient±SE: 0.08 ± 0.04; p = 0.04) while IUD use was associated with a lower likelihood (coefficient±SE: -1.8 ± 0.9; p = 0.04). No other hormonal contraception type was independently associated with self-reported menstrual regularity. CONCLUSION: These results collectively suggest, within a population of generally healthy, young adult females, that lower BFP and hormonal IUD use are both independently associated with a lower likelihood of having a regular menstrual cycle. When assessing the lack of a regular menstrual cycle, practitioners may consider hormonal IUD use as one potential factor in addition to a general assessment of body composition and energy availability. However, this analysis was limited by a relatively small sample size, which may have reduced the ability to detect the relationship between menstrual regularity and less commonly used contraceptive types. Future research is required to determine the relationship between these contraceptive types and menstrual regularity in generally healthy adult females

Relationships between Body Composition and Game Day Training Load in Ice Hockey Players

Body composition can impact physical activities and exercise performance. However, relationships between body composition and workload during ice hockey games remain unknown. PURPOSE: To examine relationships between body composition and game day training load in ice hockey players. METHODS: Eleven highly-trained ice hockey players (10 males, 1 female; mean ± standard deviation; age, 21.73 ± 1.34 yrs.; height, 179.93 ± 8.49 cm; body mass, 76.87 ± 14.38 kg, body fat percentage [BFP]: 18.0 ± 7.9% [mean ± SD]; fat-free mass index [FFMI]: 19.8 ± 2.2 kg/m2) participated in the study. First, participants visited the laboratory to assess their body composition by dual-energy X-ray absorptiometry and 3-dimensional optical imaging. Then, participants wore a player tracking device to monitor training load during an entire ice hockey game. Pearson correlations were utilized to assess relationships between selected body composition (body fat percentage [BFP], fat-free mass index [FFMI]) and training load metrics (average heart rate [HR], training impulse [TRIMP]). RESULTS: No statistically significant correlations between the selected body composition and training load variables were observed. Correlation coefficients were negative for the relationship between BFP and TRIMP (r = -0.46, p = 0.15) and between BFP and HR (r = -0.49, p = 0.12). In contrast, correlation coefficients were positive for the relationship between FFMI and TRIMP (r = 0.57, p = 0.07) and between FFMI and HR (r = 0.49, p = 0.12). CONCLUSION: With no statistically significant associations between training load and body composition, BFP and FFM might not impact workload in the ice hockey players during the game. However, further investigation will be necessary to establish this finding more definitively, due to the utilization of a single game’s training load and a modest sample of players

Separate Pathways for Antigen Presentation by CD1 Molecules

AbstractThe ability to sample relevant intracellular compartments is necessary for effective antigen presentation. To detect peptide antigens, MHC class I and II molecules differentially sample cytosolic and endosomal compartments. CD1 constitutes another lineage of lipid antigen-presenting molecules. We show that CD1b traffics deeply into late endosomal compartments, while CD1a is excluded from these compartments and instead traffics independently in the recycling pathway of the early endocytic system. Further, CD1b but not CD1a antigen presentation is dependent upon vesicular acidification. Since lipids and various bacteria are known to traffic differentially, either penetrating deeply into the endocytic system or following the route of recycling endosomes, these findings elucidate efficient monitoring of distinct components of the endocytic compartment by CD1 lipid antigen-presenting molecules

CCR2 and CXCR4 regulate peripheral blood monocyte pharmacodynamics and link to efficacy in experimental autoimmune encephalomyelitis

<p>Abstract</p> <p>Background</p> <p>CCR2 plays a key role in regulating monocyte trafficking to sites of inflammation and therefore has been the focus of much interest as a target for inflammatory disease.</p> <p>Methods</p> <p>Here we examined the effects of CCR2 blockade with a potent small molecule antagonist to determine the pharmacodynamic consequences on the peripheral blood monocyte compartment in the context of acute and chronic inflammatory processes.</p> <p>Results</p> <p>We demonstrate that CCR2 antagonism <it>in vivo </it>led to a rapid decrease in the number of circulating Ly6C^himonocytes and that this decrease was largely due to the CXCR4-dependent sequestration of these cells in the bone marrow, providing pharmacological evidence for a mechanism by which monocyte dynamics are regulated <it>in vivo</it>. CCR2 antagonism led to an accumulation of circulating CCL2 and CCL7 levels in the blood, indicating a role for CCR2 in regulating the levels of its ligands under homeostatic conditions. Finally, we show that the pharmacodynamic changes due to CCR2 antagonism were apparent after chronic dosing in mouse experimental autoimmune encephalomyelitis, a model in which CCR2 blockade demonstrated a dramatic reduction in disease severity, manifest in a reduced accumulation of monocytes and other cells in the CNS.</p> <p>Conclusion</p> <p>CCR2 antagonism <it>in vivo </it>has tractable pharmacodynamic effects that can be used to align target engagement with biologic effects on disease activity.</p

Concert recording 2015-11-30

[Track 01]. Danza brasiliera / Jorge Morel -- [Track 02]. Sunburst / Andrew York -- [Track 03]. Ladron broma / Chase Chamberlin -- [Track 04]. Etudes 1, 2, & 3 / Matteo Carcassi -- [Track 05]. Invitation / Bronislaw Kaper -- [Track 06]. Ami etude / Ferdinando Carulli -- Variation (slur study) / Mauro Giuliani -- [Track 07]. Tango / Isaac Albeniz -- [Track 08]. Invention no. 8 / J.S. Bach -- [Track 09]. Don\u27t get around much anymore / Duke Ellington -- [Track 10]. Turnaround / Omette Coleman -- [Track 11]. Julia Florida / Augustin Barrios -- [Track 12]. Estudio 9 / Fernando Sor -- [Track 13]. Billie\u27s bounce / C. Parker -- [Track 14]. Emily / J. Mandel -- [Track 15]. Lagrima, Adelita / F. Tarrega

Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis

Caspase-1 is activated by a variety of stimuli after the assembly of the “inflammasome,” an activating platform made up of a complex of the NOD-LRR family of proteins. Caspase-1 is required for the secretion of proinflammatory cytokines, such as interleukin (IL)-1β and IL-18, and is involved in the control of many bacterial infections. Paradoxically, however, its absence has been reported to confer resistance to oral infection by Salmonella typhimurium. We show here that absence of caspase-1 or components of the inflammasome does not result in resistance to oral infection by S. typhimurium, but rather, leads to increased susceptibility to infection