A self-consistent test of Comptonization models using a long BeppoSAX observation of NGC 5548

We test accurate models of Comptonization spectra over the high quality data of the BeppoSAX long look at NGC 5548. The data are well represented by a plane parallel corona with an inclination angle of 30$^{\circ}$, a soft photon temperature of 5 eV and a hot plasma temperature and optical depth of $kT_{\rm e}\simeq$ 360 keV and $\tau\simeq$ 0.1, respectively. If energy balance applies, such values suggest that a more ``photon-starved'' geometry (e.g. a hemispheric region) is necessary. The spectral softening detected during a flare, appears to be associated to a decrease of the heating-to-cooling ratio, indicating a geometric and/or energetic modification of the disk plus corona system. The hot plasma temperature derived with the models above is significantly higher than that obtained fitting the same data with a power law plus high energy cut off model for the continuum. This is due to the fact that in anisotropic geometries Comptonization spectra show "intrinsic" curvature which moves the fitted high energy cut-off to higher energies.Comment: 4 pages, 2 figures, to appear in the proceedings of the conference "X-ray Astronomy '99", Bologna, Italy, September 199

WARP: a WIMP double phase Argon detector

The WARP programme for dark matter search with a double phase argon detector is presented. In such a detector both excitation and ionization produced by an impinging particle are evaluated by the contemporary measurement of primary scintillation and secondary (proportional) light signal, this latter being produced by extracting and accelerating ionization electrons in the gas phase. The proposed technique, verified on a 2.3 liters prototype, could be used to efficiently discriminate nuclear recoils, induced by WIMP's interactions, and measure their energy spectrum. An overview of the 2.3 liters results and of the proposed 100 liters detector is shown.Comment: Proceeding for IDM200

Contribution of human retroviruses to disease development-A focus on the HIV- And HERV-cancer relationships and treatment strategies

Animal retroviruses are known for their transforming potential, and this is also true for the ones hosted by humans, which have gathered expanding attention as one of the potent causative agents in various disease, including specific cancer types. For instance, Human T Lymphotropic virus (HTLV) is a well-studied class of oncoviruses causing T cell leukemia, while human immunodeficiency virus (HIV) leads to acquired immunodeficiency syndrome (AIDS), which is linked to a series of defining cancers including Kaposi sarcoma, certain types of non-Hodgkin lymphoma, and cervical cancer. Of note, in addition to these “modern” exogenous retroviruses, our genome harbors a staggering number of human endogenous retroviruses (HERVs). HERVs are the genetic remnants of ancient retroviral germline infection of human ancestors and are typically silenced in normal tissues due to inactivating mutations and sequence loss. While some HERV elements have been appropriated and contribute to human physiological functions, others can be reactivated through epigenetic dysregulations to express retroviral elements and promote carcinogenesis. Conversely, HERV replication intermediates or protein products can also serve as intrinsic pathogen-associated molecular patterns that cause the immune system to interpret it as an exogenous infection, thereby stimulating immune responses against tumors. As such, HERVs have also been targeted as a potential internal strategy to sensitize tumor cells for promising immunotherapies. In this review, we discuss the dynamic role of human retroviruses in cancer development, focusing on HIV and HERVs contribution. We also describe potential treatment strategies, including immunotherapeutic targeting of HERVs, inhibiting DNA methylation to expose HERV signatures, and the use of antiretroviral drugs against HIV and HERVs, which can be employed as prospective anti-cancer modalities

Ultraviolet and Multiwavelength Variability of the Blazar 3C 279: Evidence for Thermal Emission

The gamma-ray blazar 3C 279 was monitored on a nearly daily basis with IUE, ROSAT and EGRET for three weeks between December 1992 and January 1993. During this period, the blazar was at a historical minimum at all wavelengths. Here we present the UV data obtained during the above multiwavelength campaign. A maximum UV variation of ~50% is detected, while during the same period the X-ray flux varied by no more than 13%. At the lowest UV flux level the average spectrum in the 1230-2700 A interval is unusually flat for this object (~1). The flattening could represent the lowest energy tail of the inverse Compton component responsible for the X-ray emission, or could be due to the presence of a thermal component at ~20000 K possibly associated with an accretion disk. The presence of an accretion disk in this blazar object, likely observable only in very low states and otherwise hidden by the beamed, variable synchrotron component, would be consistent with the scenario in which the seed photons for the inverse Compton mechanism producing the gamma-rays are external to the relativistic jet. We further discuss the long term correlation of the UV flux with the X-ray and gamma-ray fluxes obtained at various epochs. All UV archival data are included in the analysis. Both the X- and gamma-ray fluxes are generally well correlated with the UV flux, approximately with square root and quadratic dependences, respectively.Comment: 22 pages, Latex, 7 PostScript figures, to appear in The Astrophysical Journa

Scalability tests of R-GMA-based grid job monitoring system for CMS Monte Carlo data production

Copyright @ 2004 IEEEHigh-energy physics experiments, such as the compact muon solenoid (CMS) at the large hadron collider (LHC), have large-scale data processing computing requirements. The grid has been chosen as the solution. One important challenge when using the grid for large-scale data processing is the ability to monitor the large numbers of jobs that are being executed simultaneously at multiple remote sites. The relational grid monitoring architecture (R-GMA) is a monitoring and information management service for distributed resources based on the GMA of the Global Grid Forum. We report on the first measurements of R-GMA as part of a monitoring architecture to be used for batch submission of multiple Monte Carlo simulation jobs running on a CMS-specific LHC computing grid test bed. Monitoring information was transferred in real time from remote execution nodes back to the submitting host and stored in a database. In scalability tests, the job submission rates supported by successive releases of R-GMA improved significantly, approaching that expected in full-scale production