Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview

Introduction: The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis of Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting of results may differ, which can lead to misunderstandings and raises questions about the commutability of tests. Methods: We obtained a description of (pre-)analytical protocols and sample reports from 40 centers worldwide. A consensus approach allowed us to propose harmonized comments corresponding to the different CSF biomarker profiles observed in patients. Results: The (pre-)analytical procedures were similar between centers. There was considerable heterogeneity in cutoff definitions and report comments. We therefore identified and selected by consensus the most accurate and informative comments regarding the interpretation of CSF biomarkers in the context of AD diagnosis. Discussion: This is the first time that harmonized reports are proposed across worldwide specialized laboratories involved in the biochemical diagnosis of AD

“Playing with the Border:” Alsatian Sports Societies and Alsace’s Problematic Return to France after the First World War

International audienceAnnexed by Germans in 1870, the region Alsace became French again, in 1918. After a triumphal welcom for the French troops, the Alsatians, influenced by 47 years of German presence, showcase very timidly their new nationality. In a France that cultivates anti-Germanism, the political and professional scenes do not, however, allow to claim the German heritage. It is different in the field of sport, which cultivates contradictions by playing its neutral and apolitical image. The local associations of sport maintains a special relationship with the borders and with those who live over the border. At the same time, the relationships are made of porosities and exchanges with Germany and of looking at the French territory or even at the Alsatian aera. This ambiguous positioning leads them to hesitate in two ways : on the one hand, They adopt a public posture advocating their attachment to the Republic; on the other hand, they undertake an "infrapolytic" posture of fiddling with the new borders. We will illustrate this phenomenon through the monograph of a rowing club, the “Cercle Nautique de Strasbourg”