Two dynamic exponents in the resistive transition of fully frustrated Josephson-junction arrays

We study the resistive transition in Josephson-junction arrays at $f=1/2$ flux quantum per plaquette by dynamical simulations of the resistively-shunted-junction model. The current-voltage scaling and critical dynamics of the phases are found to be well described by the same critical temperature and static exponents as for the chiral (vortex-lattice) transition. Although this behavior is consistent with a single transition scenario, where phase and chiral variables order simultaneously, two different dynamic exponents result for phase coherence and chiral order.Comment: 4 pages, 3 figures, to appear in Europhysics Letter

Phase transitions in the one-dimensional frustrated quantum XY model and Josephson-junction ladders

A one-dimensional quantum version of the frustrated XY (planar rotor) model is considered which can be physically realized as a ladder of Josephson-junctions at half a flux quantum per plaquette. This system undergoes a superconductor to insulator transition at zero temperature as a function of charging energy. The critical behavior is studied using a Monte Carlo transfer matrix applied to the path-integral representation of the model and a finite-size-scaling analysis of data on small system sizes. Depending on the ratio between the interchain and intrachain couplings the system can have single or double transitions which is consistent with the prediction that its critical behavior should be described by the two-dimensional classical XY-Ising model.Comment: 13 pages, Revtex, J. Appl. Phys. (to appear), Inpe-las-00

Phase-coherence threshold and vortex-glass state in diluted Josephson-junction arrays in a magnetic field

We study numerically the interplay of phase coherence and vortex-glass state in two-dimensional Josephson-junction arrays with average rational values of flux quantum per plaquette $f$ and random dilution of junctions. For $f=1/2$, we find evidence of a phase coherence threshold value $x_s$, below the percolation concentration of diluted junctions $x_p$, where the superconducting transition vanishes. For $x_s < x < x_p$ the array behaves as a zero-temperature vortex glass with nonzero linear resistance at finite temperatures. The zero-temperature critical currents are insensitive to variations in $f$ in the vortex glass region while they are strongly $f$ dependent in the phase coherent region.Comment: 6 pages, 4 figures, to appear in Phys. Rev.

Nuclear star formation in the quasar PG1126-041 from adaptive optics assisted spectroscopy

We present adaptive optics assisted spectroscopy of three quasars obtained with NACO at VLT. The high angular resolution achieved with the adaptive optics (~0.08"), joined to the diagnostic power of near-IR spectroscopy, allow us to investigate the properties of the innermost 100 pc of these quasars. In the quasar with the best adaptive optics correction, PG1126-041, we spatially resolve the Pa-alpha emission within the nuclear 100 pc. The comparison with higher excitation lines suggests that the narrow Pa-alpha emission is due to nuclear star formation. The inferred intensity of the nuclear star formation (13 M(sun)/yr) may account for most of the far-IR luminosity observed in this quasar.Comment: 4 pages, 4 figures. Accepted for publication in A&

Field-induced superconductor to insulator transition in Josephson-junction ladders

The superconductor to insulator transition is studied in a self-charging model for a ladder of Josephson-junctions in presence of an external magnetic field. Path integral Monte Carlo simulations of the equivalent (1+1)-dimensional classical model are used to study the phase diagram and critical behavior. In addition to a superconducting (vortex-free) phase, a vortex phase can also occur for increasing magnetic field and small charging energy. It is found that an intervening insulating phase separates the superconducting from the vortex phases. Surprisingly, a finite-size scaling analysis shows that the field-induced superconducting to insulator transition is in the KT universality class even tough the external field breaks time-reversal symmetry.Comment: 5 pages, 7 figures, to appear in Phys. Rev.

Diluted Josephson-junction arrays in a magnetic field: phase coherence and vortex glass thresholds

The effects of random dilution of junctions on a two-dimensional Josephson-junction array in a magnetic field are considered. For rational values of the average flux quantum per plaquette $f$, the superconducting transition temperature vanishes, for increasing dilution, at a critical value $x_S(f)$, while the vortex ordering remains stable up to $x_{VL}>x_S$, much below the value $x_p$ corresponding to the geometric percolation threshold. For $x_{VL}<x<x_p$, the array behaves as a zero-temperature vortex-glass. Numerical results for $f=1/2$ from defect energy calculations are presented which are consistent with this scenario.Comment: 4 pages, 4 figures, to appear in Phys. Rev.

Current-voltage scaling of a Josephson-junction array at irrational frustration

Numerical simulations of the current-voltage characteristics of an ordered two-dimensional Josephson junction array at an irrational flux quantum per plaquette are presented. The results are consistent with an scaling analysis which assumes a zero temperature vortex glass transition. The thermal correlation length exponent characterizing this transition is found to be significantly different from the corresponding value for vortex-glass models in disordered two-dimensional superconductors. This leads to a current scale where nonlinearities appear in the current-voltage characteristics decreasing with temperature $T$ roughly as $T^2$ in contrast with the $T^3$ behavior expected for disordered models.Comment: RevTex 3.0, 12 pages with Latex figures, to appear in Phys. Rev. B 54, Rapid. Com

Star Formation History and Extinction in the central kpc of M82-like Starbursts

We report on the star formation histories and extinction in the central kpc region of a sample of starburst galaxies that have similar far infrared (FIR), 10 micron and K-band luminosities as those of the archetype starburst M82. Our study is based on new optical spectra and previously published K-band photometric data, both sampling the same area around the nucleus. Model starburst spectra were synthesized as a combination of stellar populations of distinct ages formed over the Hubble time, and were fitted to the observed optical spectra and K-band flux. The model is able to reproduce simultaneously the equivalent widths of emission and absorption lines, the continuum fluxes between 3500-7000 Ang, the K-band and the FIR flux. We require a minimum of 3 populations -- (1) a young population of age < 8 Myr, with its corresponding nebular emission, (2) an intermediate-age population (age < 500 Myr), and (3) an old population that forms part of the underlying disk or/and bulge population. The contribution of the old population to the K-band luminosity depends on the birthrate parameter and remains above 60% in the majority of the sample galaxies. Even in the blue band, the intermediate age and old populations contribute more than 40% of the total flux in all the cases. A relatively high contribution from the old stars to the K-band nuclear flux is also apparent from the strength of the 4000 Ang break and the CaII K line. The extinction of the old population is found to be around half of that of the young population. The contribution to the continuum from the relatively old stars has the effect of diluting the emission equivalent widths below the values expected for young bursts. The mean dilution factors are found to be 5 and 3 for the Halpha and Hbeta lines respectively.Comment: 20 pages, uses emulateapj.cls. Scheduled to appear in ApJ Jan 1, 200

Chloroquine supplementation increases the cytotoxic effect of curcumin against Her2/neu overexpressing breast cancer cells in vitro and in vivo in nude mice while counteracts it in immune competent mice

Autophagy is usually a pro-survival mechanism in cancer cells, especially in the course of chemotherapy, thus autophagy inhibition may enhance the chemotherapy-mediated anti-cancer effect. However, since autophagy is strongly involved in the immunogenicity of cell death by promoting ATP release, its inhibition may reduce the immune response against tumors, negatively influencing the overall outcome of chemotherapy. In this study, we evaluated the in vitro and in vivo anti-cancer effect of curcumin (CUR) against Her2/neu overexpressing breast cancer cells (TUBO) in the presence or in the absence of the autophagy inhibitor chloroquine (CQ). We found that TUBO cell death induced by CUR was increased in vitro by CQ and slightly in vivo in nude mice. Conversely, CQ counteracted the Cur cytotoxic effect in immune competent mice, as demonstrated by the lack of in vivo tumor regression and the reduction of overall mice survival as compared with CUR-treated mice. Immunohistochemistry analysis revealed the presence of a remarkable FoxP3 T cell infiltrate within the tumors in CUR/CQ treated mice and a reduction of T cytotoxic cells, as compared with single CUR treatment. These findings suggest that autophagy is important to elicit anti-tumor immune response and that autophagy inhibition by CQ reduces such response also by recruiting T regulatory (Treg) cells in the tumor microenvironment that may be pro-tumorigenic and might counteract CUR-mediated anti-cancer effects