Patógenos de importancia clínica

PublishedEl presente libro Patógenos de importancia clínica: Inves­tigaciones Recientes en el Valle del Cauca nace como una iniciativa para socializar los resultados obtenidos en los tra­bajos de investigación más recientes de los miembros del Grupo de Investigación en genética, fisiología y metabolis­mo –GEFIME– de la Universidad Santiago de Cali. Estas investigaciones involucran patógenos que son importantes agentes causales de infecciones y de alto impacto en la salud pública en la ciudad de Cali y en el Valle del Cauca. Este libro consta de cinco capítulos con trabajos de investiga­ción en bacterias resistentes a los antibióticos como Staphylo­coccus aureus y Mycobacterium tuberculosis y su comporta­miento epidemiológico en ambientes intrahospitalarios y en poblaciones, respectivamente. En el Capítulo 3 se presenta un estudio epidemiológico que establece la presencia del virus del papiloma humano (VPH) en mucosa oral y su relación con el desarrollando cáncer oral y en el Capítulo 4 se presenta una investigación realizada con moléculas efectoras (alarmona pp­Gpp y la proteína DksA) de Salmonella enterica serovar Typhi­murium y su influencia en la patogenicidad y la formación de biopelículas in-vitro

Delayed colorectal cancer care during covid-19 pandemic (decor-19). Global perspective from an international survey

Background The widespread nature of coronavirus disease 2019 (COVID-19) has been unprecedented. We sought to analyze its global impact with a survey on colorectal cancer (CRC) care during the pandemic. Methods The impact of COVID-19 on preoperative assessment, elective surgery, and postoperative management of CRC patients was explored by a 35-item survey, which was distributed worldwide to members of surgical societies with an interest in CRC care. Respondents were divided into two comparator groups: 1) ‘delay’ group: CRC care affected by the pandemic; 2) ‘no delay’ group: unaltered CRC practice. Results A total of 1,051 respondents from 84 countries completed the survey. No substantial differences in demographics were found between the ‘delay’ (745, 70.9%) and ‘no delay’ (306, 29.1%) groups. Suspension of multidisciplinary team meetings, staff members quarantined or relocated to COVID-19 units, units fully dedicated to COVID-19 care, personal protective equipment not readily available were factors significantly associated to delays in endoscopy, radiology, surgery, histopathology and prolonged chemoradiation therapy-to-surgery intervals. In the ‘delay’ group, 48.9% of respondents reported a change in the initial surgical plan and 26.3% reported a shift from elective to urgent operations. Recovery of CRC care was associated with the status of the outbreak. Practicing in COVID-free units, no change in operative slots and staff members not relocated to COVID-19 units were statistically associated with unaltered CRC care in the ‘no delay’ group, while the geographical distribution was not. Conclusions Global changes in diagnostic and therapeutic CRC practices were evident. Changes were associated with differences in health-care delivery systems, hospital’s preparedness, resources availability, and local COVID-19 prevalence rather than geographical factors. Strategic planning is required to optimize CRC care