2 research outputs found
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity
- Author
- Aanensen David M.
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Adriaenssens Evelien M.
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad S.Y.
- Alam Mohammad T.
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
- Allan John
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angyal Adrienn
- Aranday-Cortes Elihu
- Ariani Cristina
- Asad Hibo
- Asamaphan Patawee
- Ashworth Jordan
- Atkinson Laura
- Attwood Stephen
- Auckland Cressida
- Awan Ali R.
- Aydin Alp
- Baker David J.
- Baker Paul
- Balcazar Carlos E.
- Ball Jonathan
- Barton Edward
- Bashton Matthew
- Batra Rahul
- Baxter Laura
- Beale Mathew A.
- Beaver Charlotte
- Beckett Angela
- Beer Robert
- Beggs Andrew
- Bell Andrew
- Bellis Katherine L.
- Berger Duncan J.
- Berriman Matt
- Berry Lisa
- Berry Louise
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire M.
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blane Beth
- Bolt Frances
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- Boyes John
- Bradley Declan T.
- Bradshaw Daniel
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah E.
- Brooks Tony T.
- Broos Alice
- Brown Julianne Rose
- Brown Paul E.
- Brown Rebecca
- Brunker Kirstyn
- Bucca Giselda
- Buck David
- Buddenborg Sarah K.
- Bull Matthew
- Bull Matthew
- Burton-Fanning Shirelle
- Butcher Ethan
- Caddy Sarah L.
- Caller Laura G.
- Campbell Sharon
- Carlile Matthew
- Carmichael Stephen N.
- Casey Anna
- Castellano Sergi
- Chalker Vicki
- Chand Meera
- Chapman Michael R.
- Chappell Joseph G.
- Charalampous Themoula
- Charles Ian G.
- Chaudhry Yasmin
- Chauhan Anoop J.
- Cheng Jeffrey K.J.
- Churcher Carol M.
- Clark Gemma
- Coll Francesc
- Collins Jennifer
- Colquhoun Rachel
- Colquhoun Rachel M.
- Connor Thomas R.
- Connor Thomas R.
- Constantinidou Chrystala
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cortes Nick
- Cottrell Simon
- Coupland Lindsay J.
- Cowell Angela
- Cox Alison
- Craine Noel
- Cronin Michelle
- Crooke Derrick
- Curran Martin D.
- Curran Tanya
- da Silva Filipe Ana
- da Silva Filipe Ana
- Dabrera Gavin
- Danesh John
- Darby Alistair C.
- Davidson Rose K.
- Davies Alisha
- Davis Thomas
- de Cesare Mariateresa
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I.
- Debebe Johnny
- Dervisevic Samir
- Dewar Rebecca
- Dias Joana
- Diaz Maria
- Dibling Thomas
- Dorman Matthew J.
- Downing Fatima
- Drury Eleanor
- du Plessis Louis
- Duckworth Nichola
- Dyal Patricia L.
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Ellard Sian
- Elliott Scott
- Eltringham Gary
- Elumogo Ngozi
- Essex Sarah
- Evans Cariad
- Evans Johnathan M.
- Eyre David
- Fairley Derek J.
- Fallon Karlie
- Farbos Audrey
- Farr Ben
- Feltwell Theresa
- Fina Laia
- Findlay Jacqueline
- Fisher Chloe L.
- Fleming Vicki M.
- Forrest Leysa M.
- Forrest Sally
- Foulser Luke
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M.
- Frost Lucy R.
- Fuller William
- Gallagher Eileen
- Gallagher Michael D.
- Garcia-Casado Maria V.
- Gaskin Amy
- Gatica-Wilcox Bree
- Gavriil Artemis
- Geidelberg Lily
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P.
- Gifford Laura
- Gilbert Lauren
- Gill Harmeet K.
- Gilroy Rachel A.J.
- Girgis Sophia T.
- Glaysher Sharon
- Golubchik Tanya
- Goncalves Sonia
- Goodfellow Ian
- Goodfellow Ian G.
- Goodwin Scott
- Graham Clive
- Graham Lee
- Gramatopoulos Dimitris
- Green Angie
- Green Luke R.
- Greenaway Jane
- Gregory Richard
- Griffith Luke
- Groves Danielle C.
- Groves Natalie
- Guest Martyn
- Gulliver Huw
- Gutierrez Ana Victoria
- Hadjirin Nazreen F.
- Haldenby Sam T.
- Hale Antony D.
- Hall Grant
- Halstead Fenella
- Hamilton William L.
- Haque Tanzina
- Harper Katherine L.
- Harris Kathryn Ann
- Harrison Ewan M.
- Harrison Ian
- Harrison James W.
- Hartman Hassan
- Hattersley Andrew
- Heaney Judith
- Helmer Thomas
- Hesketh Andrew R.
- Heyburn David
- Higginson Ellen E.
- Hill Verity
- Hill Verity
- Hilvers Ember
- Hiscox Julian A.
- Holden Matthew T.G.
- Holmes Alison
- Holmes Christopher
- Holmes Nadine
- Hoosdally Sarah
- Hopes Richard
- Hosmillo Myra
- Houldcroft Charlotte J.
- Howe Robin
- Howson-Wells Hannah C.
- Hubb Jonathan
- Hughes Joseph
- Hughes Margaret
- Hunter Adam D.
- Hutchings Stephanie
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Jackson Ben
- Jackson Ben
- Jackson David A.
- Jackson David K.
- Jackson Kathryn A.
- Jahun Aminu S.
- James Keith
- Jamrozy Dorota
- Jarrett Ruth
- Jeffries Aaron R.
- Jesudason Natasha
- Jesudason Natasha G.
- John Michaela
- Johnson Kate
- Johnson Natasha
- Johnson Rob
- Johnson Robert
- Johnston Ian
- Jones Hannah
- Jones Katie
- Jones Rachel
- Jones Sophie
- Jorgensen David
- Jorgensen David
- Joseph Amelia
- Justice Anita
- Kane Leanne
- Kay Gemma L.
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander J.
- Kenyon Anita
- Kermack Leanne M.
- Khakh Manjinder
- Khokhar Fahad A.
- Kidd Stephen
- Kingsley Robert A.
- Kitchen Christine
- Knight Bridget A.
- Kolyva Anastasia
- Koshy Cherian
- Kraemer Moritz
- Kristiansen Mark
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Langford Cordelia
- Lawniczak Mara
- Le-Viet Thanh
- Lee David
- Lee Jack C.D.
- Letchford Laura
- Levene Nick
- Levett Lisa J.
- Li Kathy
- Li Kathy K.
- Liggett Steven
- Lindsey Benjamin B.
- Lister Michelle M.
- Livett Rich
- Lloyd Allyson
- Lo Stephanie
- Loh Joshua
- Loman Nicholas J.
- Loman Nicholas J.
- Loose Matthew W.
- Loveson Katie F.
- Lowe Hannah
- Lucaci Anita O.
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A.
- Macfarlane-Smith Louissa R.
- Machin Nicholas W.
- MacIntyre-Cockett George
- Madona Pinglawathee
- Maes Mailis
- Mahungu Tabitha W.
- Mair Daniel
- Maksimovic Joshua
- Manesis Nikos
- Manley Robin
- Manso Carmen
- Marchbank Angela
- Martincorena Inigo
- Martinez-Nunez Rocio T.
- Masoli Jane A.H.
- Mason Jenifer
- Mather Alison E.
- Mbisa Tamyo
- McCluggage Kathryn
- McClure Patrick C.
- McCrone J.T.
- McCrone John T.
- McGuigan Samantha
- McHugh Martin P.
- McKenna James P.
- McKerr Caoimhe
- McMinn Liz
- McMurray Claire
- Meader Emma J.
- Meadows Lizzie
- Menegazzo Mirko
- Meredith Luke W.
- Merrick Ian
- Mestek-Boukhibar Lamia
- Miah Shahjahan
- Michell Stephen L.
- Michelsen Michelle L.
- Molnar Zoltan
- Monaghan Lynn
- Mookerjee Siddharth
- Moore Catherine
- Moore Catrin
- Moore Christopher
- Moore Nathan
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Moses Samuel
- Muir Peter
- Munn Robert
- Myers Richard
- Nascimento Fabricia F.
- Nascimento Fabricia F.
- Naydenova Plamena
- Neaverson Alexandra S.
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nelson Rachel
- Nicholls Sam
- Nicholls Samuel M.
- Nichols Jenna
- Niebel Marc O.
- Niola Paola
- Nomikou Kyriaki
- O'Toole Elaine
- O'Toole Ăine
- Orton Richard J.
- Osman Husam
- Ott Sascha
- OâGrady Justin
- OâToole Ăine
- Pacchiarini Nicole
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J.
- Palmer Sophie
- Palmer Steve
- Panchbhaya Yasmin N.
- Pandey Sarojini
- Park Naomi
- Parker Matthew D.
- Parmar Surendra
- Parr Yasmin A.
- Parsons Paul J.
- Partridge David G.
- Pascall David J.
- Patel Gaurang
- Patel Minal
- Patel Vineet
- Paterson Steve
- Payne Brendan A.I.
- Peacock Sharon J.
- Pearson Clare
- Perry Malorie
- Peto Timothy
- Pinckert Malte L.
- Platt Steven
- Plimmer Amy
- Poplawski Radoslaw
- Potter Will
- Prakash Reenesh
- Prestwood Liam
- Price Anna
- Price Anna
- Price James
- Puethe Christoph
- Pybus Oliver
- Pybus Oliver G.
- Pymont Hannah M.
- Quail Mike
- Quick Joshua
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajatileka Shavanthi
- Rambaut Andrew
- Rambaut Andrew
- Ramsay Mary
- Randell Paul A.
- Raviprakash Veena
- Raza Mohammad
- Resende Silva Paola C.
- Rey Sara
- Rey Sara M.
- Reynolds Nicola
- Richter Alex
- Robertson David L.
- Robertson David L.
- Robinson Esther
- Robinson Trevor I.
- Robson Samuel C.
- Rogers Hazel A.
- Rooke Stefan
- Rowan Aileen
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Ryan Felicity
- Sambles Christine M.
- Sang Fei
- Scarlett Garry P.
- Schaefer Ulf
- Scher Emily
- Scott Carol
- Scott Garren
- Sethi Dheeraj K.
- Shaaban Sharif
- Shah Divya
- Shah Rajiv
- Shah Rajiv N.
- Shankar Giri
- Shaw Robert
- Shepherd James
- Shepherd James G.
- Sheriff Nicola
- Shirley Lesley
- Signell Adrian W.
- Sillitoe John
- Simpson David A.
- Singer Joshua B.
- Sivaprakasam Venkat
- Siveroni Igor
- Siveroni Igor
- Sloan Tim J.
- Sluga Graciela
- Smith Christen
- Smith Colin P.
- Smith Darren
- Smith Nikki
- Smith Wendy
- Smollett Katherine L.
- Snell Luke B.
- Souster Emily
- Southgate Joel
- Southgate Joel
- Spellman Karla
- Spencer-Chapman Michael
- Sridhar Sushmita
- Stanley Rachael
- Stanton Thomas D.
- Starinskij Igor
- Stark Richard
- Stockton Joanne
- Stuart Claire
- Studholme David J.
- Swindells Emma
- Swingler Tracey
- Taha Yusri
- Tang Julian
- Taylor Ben E.W.
- Taylor Graham P.
- Taylor Sarah
- Taylor-Joyce Grace
- Tedim Ana P.
- Temperton Ben
- Templeton Kate E.
- Thompson Thomas
- Thomson Emma C.
- Thomson Emma C.
- Thomson Nicholas M.
- Thornton Alicia
- Thurston Scott
- Todd John A.
- Tong Lily
- Tonkin-Hill Gerry
- Torok M. Estee
- Trebes Amy
- Trotter Alexander J.
- Tsoleridis Theocharis
- Tucker Rachel M.
- Turtle Lance
- Tutill Helena J.
- Underwood Anthony P.
- Unnikrishnan Meera
- Vamos Edith E.
- Vasylyeva Tetyana
- Vattipally Sreenu
- Vipond Ian B.
- Volz Erik
- Volz Erik M.
- Wain John
- Walsh Sarah
- Wang Dennis
- Wantoch Michelle
- Warne Ben
- Warwick-Dugdale Joanna
- Wastenge Elizabeth
- Watkins Joanne
- Watts Joanne
- Waugh Sheila
- Webber Mark A.
- Weeks Sam
- Weldon Danni
- Whitehead Mark
- Williams Charlotte A.
- Williams Chris
- Williams David
- Williams Rachel J.
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A.
- Willingham Iona
- Wilson Harry D.
- Wise Emma
- Workman Trudy
- Wright Victoria
- Wyles Matthew
- Wyllie Sarah
- Yakovleva Anna
- Yasir Muhammad
- Yeats Corin A.
- Yew Wen C.
- Young Gregory R.
- Young Jamie
- Yu Xiaoyu
- Zarebski Alex
- Publication venue
- Elsevier
- Publication date
- 07/01/2021
- Field of study
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant
SARS-CoV-2 evolution during treatment of chronic infection
- Author
- Aanensen D. M.
- Abnizova I.
- Abudahab K.
- Acheson E.
- Adams A.
- Adams H.
- Afifi S.
- Aggarwal D.
- Ahmad S. S. Y.
- Aigrain L.
- Aigrain L.
- Alam M. T.
- Alcolea-Medina A.
- Alderton A.
- Alderton A.
- Ali M.
- Alikhan N. -F.
- Allara E.
- Allen L.
- Allison J.
- Amato R.
- Amato R.
- Anderson R.
- Andersson M.
- Angyal A.
- Ansaripour A.
- Aranday-Cortes E.
- Ariani C.
- Ariani C. V.
- Asad H.
- Asamaphan P.
- Ash A.
- Ashcroft F.
- Atkinson L.
- Attwood S. W.
- Auckland C.
- Austin-Guest S.
- Awan A. R.
- Aydin A.
- Baker D. J.
- Baker P.
- Baker S.
- Bala S.
- Balcazar C. E.
- Ball J.
- Barcenas-Morales G.
- Barrett J.
- Barrett J.
- Barton E.
- Bashton M.
- Bassett A.
- Bassett A. R.
- Batra R.
- Battleday K.
- Baxter L.
- Bayzid N.
- Beal J.
- Beale M.
- Beale M. A.
- Beaver C.
- Beaver C.
- Beckett A. H.
- Bedford L.
- Beer R.
- Beggs A.
- Bellany S.
- Bellerby T.
- Bellis K.
- Bellis K. L.
- Bergamaschi L.
- Berger D.
- Berriman M.
- Berry L.
- Berry L.
- Best A.
- Betancor G.
- Betancourt A.
- Betteridge E.
- Betteridge E.
- Bevan P.
- Bewshea C. M.
- Bibby D.
- Bicknell K.
- Binley S.
- Birchley A.
- Bird P.
- Bishop C.
- Bishop J.
- Blackburn K.
- Blacow R.
- Blakey V.
- Blane B.
- Blane E.
- Bolt F.
- Bonfield J.
- Bonfield J.
- Bong S. -H.
- Bonner S.
- Bonsall D.
- Boswell T.
- Bosworth A.
- Boughton N.
- Bourgeois Y.
- Bower G.
- Bowker S.
- Boyd O.
- Boyes J.
- Bradley A.
- Bradley D. T.
- Bradley J. R.
- Bradshaw D.
- Breen C.
- Brendler-Spaeth T.
- Bresner C.
- Breuer J.
- Bridgewater H. E.
- Briggs J. A. G.
- Bronner I.
- Bronner I. F.
- Brooklyn T.
- Brooks E.
- Broos A.
- Brown J. R.
- Brown P. E.
- Brown R.
- Bucca G.
- Buck D.
- Bucke A.
- Buddenborg S. K.
- Bull M.
- Bullman B.
- Bunclark K.
- Burton-Fanning S.
- Bush R.
- Butcher H.
- Caetano C.
- Cagan A.
- Calder J.
- Campbell S.
- Canna L.
- Caputo D.
- Carabelli A. M.
- Carden H.
- Carlile M.
- Carmichael S. N.
- Carter N.
- Cartwright J.
- Casey A.
- Cerda A. C.
- Ceron-Gutierrez L.
- Chalker V.
- Chand M.
- Chandra A.
- Chapman L.
- Chapman M. R.
- Chappell J. G.
- Charalampous T.
- Chatterton W.
- Chaudhry Y.
- Chauhan A. J.
- Cheng J. K. J.
- Chillingworth T. -J.
- Churcher C. M.
- Clapham P.
- Clapham-Riley D.
- Clark G.
- Clark R.
- Clarke A.
- Clarke C.
- Cogger B. J.
- Cole D.
- Coll F.
- Collier D. A.
- Collins J.
- Connor T. R.
- Constantinidou C.
- Cook E.
- Cook K.
- Coombes J.
- Coppola M.
- Corden S.
- Cormie C.
- Cornell L.
- Cornwell C.
- Cortes N.
- Corton C.
- Cossetti C.
- Cotic M.
- Cottrell S.
- Coudert J. D.
- Coupland L.
- Cowell A.
- Cox A.
- Crackett A.
- Craine N.
- Cranage A.
- Craven H.
- Craw S.
- Crawford L.
- Crawford M.
- Cronin M.
- Crook D.
- Cumley N.
- Curran M. D.
- Curran T.
- Cutts T.
- da Silva Filipe A.
- Dabrera G.
- Dabrowska M.
- Dadrah A.
- Danesh J.
- Darby A. C.
- Datir R. P.
- Davidson R. K.
- Davies A.
- Davies M.
- Davies R.
- Davies R.
- Davis T.
- Dawson J.
- Day C.
- De Bie E. M. D. D.
- de Cesare M.
- De Lacy E.
- de Oliveira Martins L.
- De Sa A.
- de Silva T. I.
- Debebe J.
- Densem A.
- Dent H.
- Dervisevic S.
- Dewar R.
- Dewhurst E.
- di Stefano G.
- Dias J.
- Dibling T.
- Dockree C.
- Dodd D.
- Doffinger R.
- Dogga S.
- Domingo J.
- Dorman M. J.
- Dougan G.
- Dougan G.
- Dougherty M.
- Dove A.
- Downing F.
- Drummond L.
- Drury E.
- Drury E.
- du Plessis L.
- Duckworth N.
- Dudek M.
- Dunmore B. J.
- Durham J.
- Durham J.
- Durrant L.
- Easthope E.
- Eccles R.
- Eckert S.
- Edgeworth J.
- Edwards S.
- Eldirdiri S.
- Ellaby N.
- Ellard S.
- Elliott S.
- Ellis P.
- Elmer A.
- Eltringham G.
- Ensell L.
- Epping M.
- Essex S.
- Estee Torok M.
- Evans C.
- Evans J. M.
- Eyre D.
- Fahey C.
- Fairley D. J.
- Fallon K.
- Farbos A.
- Farr B.
- Farr B. W.
- Fawke S.
- Fawke S.
- Fearn C.
- Fenton M.
- Fenton M. L.
- Ferreira I. A. T. M.
- Ferrero M.
- Fina L.
- Fisher C. L.
- Flack N.
- Flaviani F.
- Fleming V. M.
- Fordham H.
- Forrest S.
- Forsythe G.
- Foulser L.
- Foulser L.
- Francis M.
- Francois S.
- Fraser A.
- Fraser C.
- Freeman A.
- Freeman T. M.
- Frost L. R.
- Fuller S.
- Fuller W.
- Furlong A.
- Galai K.
- Gallagher E.
- Gallagher M. D.
- Gallis M.
- Galvin A.
- Garcia-Casado M.
- Gaskin A.
- Gatica-Wilcox B.
- Gayed S.
- Gedny A.
- Geidelberg L.
- Gemmell M.
- Georgana I.
- George R. P.
- Gifford L.
- Gilbert L.
- Gill H. K.
- Girgis S.
- Girgis S. T.
- Gkrania-Klotsas E.
- Glaysher S.
- Gleadall N.
- Glover J.
- Goldstein R. A.
- Golubchik T.
- Goncalves S.
- Goncalves S.
- Goodfellow I. G.
- Goodwin S.
- Goodwin S.
- Goudarzi S.
- Gould O.
- Gouliouris T.
- Gourtovaia M.
- Gourtovaia M.
- Graf S.
- Graham C.
- Graham L.
- Gramatopoulos D.
- Graves B.
- Gray A.
- Gray E.
- Gray J.
- Green A.
- Green L. R.
- Greenaway J.
- Gregory R.
- Grenfell R.
- Griffiths C.
- Groves D. C.
- Groves N.
- Gu Y.
- Guerin F.
- Guest M.
- Gulliver H.
- Gunson R. N.
- Gupta R. K.
- Gutierrez B.
- Hadjirin N. F.
- Haldenby S. T.
- Hale A. D.
- Hall G.
- Halstead F.
- Hamilton W.
- Hamilton W. L.
- Hanks H.
- Haque T.
- Harper K. L.
- Harris J.
- Harris K. A.
- Harrison E.
- Harrison E. M.
- Harrison I.
- Harrison J. W.
- Harrott A.
- Harry E.
- Hart J.
- Hartley J. A.
- Hartman H.
- Harvison J.
- Hassan-Ibrahim M. O.
- Heaney J.
- Heath P.
- Helmer T.
- Hernandez-Koutoucheva A.
- Hesketh A. R.
- Hess C.
- Hewitt S.
- Heyburn D.
- Higginson E. E.
- Hill V.
- Hilvers E.
- Hinch A.
- Hiscox J. A.
- Hobbs R.
- Hodgson J.
- Hogsden W.
- Holden M. T. G.
- Holland D.
- Holmes A.
- Holmes C.
- Holmes E.
- Holmes N.
- Holmes S.
- Hopes R.
- Hornett G.
- Hosmillo M.
- Hosmillo M.
- Hough N.
- Howe R.
- Howson-Wells H. C.
- Huang C.
- Hubb J.
- Huckle L.
- Hughes J.
- Hughes M.
- Hughes-Hallet L.
- Huhn O.
- Hunter A.
- Hunter K.
- Hutchings S.
- Illingworth C. J. R.
- Impey R.
- Inglis S.
- Iqbal S.
- Irish-Tavares D.
- Iturriza-Gomara M.
- Ivers T.
- Jackson A.
- Jackson C.
- Jackson D.
- Jackson D. K.
- Jackson K. A.
- Jackson S.
- Jahun A.
- Jahun A. S.
- James K.
- James K.
- Jamrozy D.
- Jamrozy D.
- Jannoo R.
- Jansen Van P.
- Jarvis I.
- Jeffries A. R.
- Jeremiah S.
- Jesudason N. G.
- John M.
- Johnson K.
- Johnson N.
- Johnson R.
- Johnston I.
- Johnston I.
- Jones C.
- Jones C. R.
- Jones E.
- Jones H.
- Jones K.
- Jones M.
- Jones R.
- Jones S.
- Jorgensen D.
- Jose S.
- Joseph A.
- Josipovic M.
- Justice A.
- Kallepally K.
- Kane L.
- Kane L.
- Karamani A.
- Kasanicki M.
- Kay G. L.
- Kay K.
- Kay S.
- Kay S.
- Keatley J.
- Keatley J. -P.
- Keeley A. J.
- Keith A.
- Kemp S. A.
- Kennet J.
- Kenyon A.
- Kermack L. M.
- Khakh M.
- Kidd S.
- King A.
- Kingston N.
- Kitchen C.
- Kitchin L.
- Kleanthous M.
- Klimekova M.
- Knight B. A.
- Korlevic P.
- Koshy C.
- Kourampa J.
- Kraemer M. U. G.
- Krasheninnkova K.
- Kristiansen M.
- Kumziene-Summerhayes S.
- Kwiatkowski D.
- Lackenby A.
- Lane G.
- Langford C.
- Langford C. F.
- Laverack A.
- Law K.
- Lawniczak M.
- Lawniczak M.
- Le Gresley E.
- Le-Viet T.
- Ledesma J.
- Lee D.
- Lee J. C. D.
- Leek D.
- Legchenko E.
- Lehner P. J.
- Leigh K. E.
- Lensing S.
- Lensing S. V.
- Leonard S.
- Leonard S.
- Letchford L.
- Letchford L.
- Levene N.
- Levett L. J.
- Lewis D.
- Lewis K.
- Lewis K.
- Lewis-Wade A.
- Li K. K.
- Liddle J.
- Liddle J.
- Liggett S.
- Lin Q.
- Lindsay S.
- Lindsey B. B.
- Linger R.
- Linsdell S.
- Lister M. M.
- Livett R.
- Livett R.
- Lloyd A.
- Lo S.
- Lo S.
- Loman N. J.
- Long R.
- Loose M. W.
- Louka S. F.
- Lovell J.
- Lovell J.
- Loveson K. F.
- Lowe H.
- Lowe H. L.
- Lucaci A. O.
- Ludden C.
- Ludden C.
- Lumb I. U.
- Lynch J.
- Lyons P. A.
- Lyons R. A.
- Macfarlane-Smith L. R.
- Machin N. W.
- MacIntyre-Cockett G.
- Mack J.
- Mackay M.
- Maclean A.
- Maddison M.
- Madona P.
- Maes M.
- Mahanama A. I. K.
- Mahungu T. W.
- Mair D.
- Maksimovic J.
- Makunin A.
- Makunin A.
- Malone C. S.
- Mamun I.
- Manesis N.
- Manley R.
- Mansfield J.
- Manso C.
- Marchbank A.
- Marriott N.
- Marsden J.
- Martin J.
- Martin M.
- Martincorena I.
- Martincorena I.
- Martinez Nunez R. T.
- Masoli J. A. H.
- Mason J.
- Matara C.
- Mather A. E.
- Matheson N. J.
- Mayhew M.
- Mayho M.
- Mbisa T.
- McCann C. M.
- McCarthy S.
- McCarthy S.
- McClintock J.
- McCluggage K.
- McClure P. C.
- McCoy L. E.
- McGuigan S.
- McGuigan S.
- McHugh M. P.
- McHugh S.
- McKenna J. P.
- McKerr C.
- McManus G. M.
- McMinn L.
- McMurray C.
- McNally A.
- Meader E. J.
- Meadows A.
- Meadows C.
- Meadows L.
- Megram O.
- Meloy S.
- Menegazzo M.
- Merrick I.
- Merrill T. V.
- Mescia F.
- Miah S.
- Michael A.
- Michel R.
- Michell S. L.
- Michelsen M. L.
- Mirza J.
- Mlcochova P.
- Mobley E.
- Modis Y.
- Moles-Garcia E.
- Moll R.
- Moll R. J.
- Mollett G.
- Molnar Z.
- Monaghan L.
- Monteiro T. C.
- Mookerjee S.
- Moore C.
- Moore C.
- Moore J.
- Moore N.
- Morgan M.
- Morgan S.
- Mori M.
- Morra M.
- Morrow L.
- Moses S.
- Muir P.
- Muldoon F.
- Munn R.
- Murie K.
- Mwaura L.
- Myers R.
- Nascimento F. F.
- Nash S.
- Nathwani C.
- Naydenova P.
- Neaverson A.
- Nebbia G.
- Nelson A.
- Nelson C.
- Nelson R.
- Nelson R.
- Nerou E.
- Nice F.
- Nicholls S.
- Nichols J.
- Nicholson J.
- Nickbakhsh S.
- Niebel M. O.
- Nimz T.
- Noell G. G.
- Nomikou K.
- O'Brien C.
- O'Brien S.
- O'Donnell C.
- O'Grady J.
- O'Meara S.
- O'Toole A.
- O'Toole E.
- Ohan V.
- Okecha G.
- Oliver K.
- Oliver K.
- Olney C.
- Omarjee O.
- Ormond D.
- Orton R. J.
- Osman H.
- Oszlanczi A.
- Ott S.
- Ovington N.
- Owehand W. H.
- Pacchiarini N.
- Padgett D.
- Page A. J.
- Palmer S.
- Palmer S.
- Palmer S.
- Pandey S.
- Pang Y. F.
- Papadia S.
- Pardubska B.
- Park N.
- Park N. R.
- Parker M. D.
- Parmar A.
- Parmar S.
- Parsons P. J.
- Partridge D. G.
- Patel A.
- Patel G.
- Patel M.
- Patel M.
- Patel V.
- Paterson S.
- Patterson C.
- Paul H.
- Payne B. A. I.
- Payne M.
- Peacock S.
- Peacock S. J.
- Pearson C.
- Pelosi E.
- Percival B.
- Perera M.
- Perry M.
- Petersen A.
- Peto T.
- Phelan I.
- Pinckert M. L.
- Platt S.
- Plimmer A.
- Plowman D.
- Pointon L.
- Polgarova P.
- Pollock D. D.
- Polwarth G.
- Pond N.
- Poplawski R.
- Preston T.
- Prestwood L.
- Prestwood L.
- Price A.
- Price J.
- Price J.
- Prieto J. A.
- Publico C.
- Puethe C.
- Puethe C.
- Pusok M.
- Pybus O. G.
- Pymont H. M.
- Quail M.
- Quail M. A.
- Quick J.
- Raghwani J.
- Ragonnet-Cronin M.
- Rainbow L.
- Rajan D.
- Rajan D.
- Rajatileka S.
- Rajatileka S.
- Rambaut A.
- Ramsay M.
- Rance R.
- Randell P. A.
- Rastall R.
- Ratcliffe L.
- Raviprakash V.
- Rawlings S.
- Raza M.
- Redshaw N.
- Redshaw N. M.
- Rees-Spear C.
- Rey S.
- Reynolds J.
- Reynolds M.
- Reynolds N.
- Ribeiro C.
- Rice S.
- Richardson M.
- Richoz N.
- Richter A.
- Roberts C.
- Roberts D. J.
- Robertson D. L.
- Robinson D.
- Robinson E.
- Robinson K.
- Robinson M.
- Robinson T. I.
- Robson S. C.
- Rogers H.
- Rojo E. M.
- Romashova V.
- Rooke S.
- Roopra D.
- Rose M.
- Rossi S.
- Rowan A.
- Rowe W.
- Rowlands J.
- Roy S.
- Rudd L.
- Rudder S.
- Ruffolo V.
- Ruis C.
- Rushton S.
- Sadri R.
- Saeed K.
- Salluja T.
- Salmon N.
- Samaraweera B.
- Sambles C. M.
- Sang F.
- Saul D.
- Saunders C.
- Scarlett G. P.
- Schaefer U.
- Schwach F.
- Scott C.
- Scott C.
- Scott G.
- Seekings P.
- Selvan M.
- Shaaban S.
- Shah D.
- Shah R. N.
- Shankar G.
- Sharma R.
- Sharrocks K.
- Shepherd J. G.
- Sheriff N.
- Shih J.
- Shirley L.
- Shirley L.
- Signell A. W.
- Sillitoe J.
- Sillitoe J.
- Silveira S.
- Simms A.
- Simpson D. A.
- Singer J. B.
- Sinnott M.
- Sivadasan S.
- Sivaprakasam V.
- Siveroni I.
- Siwek B.
- Sizer D.
- Skeldon K.
- Skelton J.
- Skittrall J. P.
- Slater-Tunstill J.
- Sloan T. J.
- Sloper L.
- Sluga G.
- Smerdon N.
- Smielewska A.
- Smith C.
- Smith C.
- Smith C.
- Smith C. P.
- Smith D. L.
- Smith J.
- Smith K.
- Smith K. G. C.
- Smith K. S.
- Smith L.
- Smith M.
- Smith N.
- Smith S.
- Smith T.
- Smith W.
- Smollett K. L.
- Sneade L.
- Snell L. B.
- Soria C. D.
- Sousa C.
- Souster E.
- Southgate J.
- Sparkes A.
- Spellman K.
- Spencer Chapman M. H.
- Spencer S.
- Spencer-Chapman M.
- Squares J.
- Sridhar S.
- Stanley R.
- Stanley R.
- Stanton T. D.
- Starinskij I.
- Stark H.
- Stark R.
- Steed C.
- Stefanucci L.
- Stephens J.
- Stickland T.
- Still I.
- Stirrups K. E.
- Stockton J.
- Stonehouse S.
- Storey N.
- Stratton M.
- Strezlecki M.
- Strickland M.
- Studholme D. J.
- Summers C.
- Sutcliffe R.
- Swann A.
- Swiatkowska A.
- Swift E.
- Swindells E.
- Sycamore N.
- Symmonds A.
- Symons E.
- Szluha S.
- Taha Y.
- Taluy E.
- Tang J.
- Tao N.
- Taylor B. E. W.
- Taylor G. P.
- Taylor K.
- Taylor S.
- Taylor S.
- Taylor-Joyce G.
- Temperton B.
- Temperton N.
- Templeton K. E.
- Thaventhiran J. E. D.
- Thompson M.
- Thompson S.
- Thompson T.
- Thomson E. C.
- Thomson M.
- Thomson N.
- Thornton A.
- Thurston S.
- Thurston S. A. J.
- Tilly T.
- Todd J. A.
- Tong L.
- Tong Z.
- Tonkin-Hill G.
- Tonkin-Hill G.
- Toombs D.
- Topping B.
- Tordesillas H.
- Toshner M.
- Tovar-Corona J.
- Tovar-Corona J. M.
- Townsend P.
- Treacy C.
- Trebes A.
- Trotter A. J.
- Tsoleridis T.
- Tucker R. M.
- Turner L.
- Turtle L.
- Twohig K. A.
- Underwood A. P.
- Ungureanu D.
- Unnikrishnan M.
- Uphill J.
- Urbanova J.
- Vamos E. E.
- van Gils M. J.
- Vancollie V.
- Vasylyeva T. I.
- Vattipally S.
- Verdejo C. J.
- Vernet G.
- Vipond I. B.
- Voak P.
- Volz E. M.
- Walker D.
- Walker M.
- Walker N.
- Waller M.
- Walsh S.
- Wang D.
- Wantoch M.
- Ward G.
- Warne B.
- Warwick-Dugdale J.
- Wastenge E.
- Watkins J.
- Watts J.
- Waugh S.
- Weatherhogg C.
- Webb N.
- Webster H. J.
- Webster J.
- Weekes M. P.
- Weldon D.
- Weldon D.
- Wells A.
- Wells E.
- Westhorpe A. P.
- Westwood L.
- Whipp T.
- Whitehead M.
- Whiteley M.
- Whiteley T.
- Whitton G.
- Whitwham A.
- Whitwham A.
- Widaa S.
- Wierzbicki C.
- Williams C.
- Williams C. A.
- Williams D.
- Williams L. -A.
- Williams M.
- Williams R.
- Williams R. J.
- Williams T.
- Williamson K. A.
- Willingham I.
- Wilson H. D.
- Wilson M.
- Wilson R. E.
- Wilson-Davies E.
- Wise E.
- Witele E.
- Wood J.
- Workman T.
- Wright S.
- Wright V.
- Wyatt T.
- Wyles M.
- Wyllie S.
- Wylot M.
- Xu-McCrae L.
- Yarkoni N. S.
- Yeats C. A.
- Yew W. C.
- Yong C.
- Young G. R.
- Young J.
- Zamudio M. E.
- Zarebski A. E.
- Zhang P.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for virus infection through the engagement of the human ACE2 protein1 and is a major antibody target. Here we show that chronic infection with SARS-CoV-2 leads to viral evolution and reduced sensitivity to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma, by generating whole-genome ultra-deep sequences for 23 time points that span 101 days and using in vitro techniques to characterize the mutations revealed by sequencing. There was little change in the overall structure of the viral population after two courses of remdesivir during the first 57 days. However, after convalescent plasma therapy, we observed large, dynamic shifts in the viral population, with the emergence of a dominant viral strain that contained a substitution (D796H) in the S2 subunit and a deletion (ÎH69/ÎV70) in the S1 N-terminal domain of the spike protein. As passively transferred serum antibodies diminished, viruses with the escape genotype were reduced in frequency, before returning during a final, unsuccessful course of convalescent plasma treatment. In vitro, the spike double mutant bearing both ÎH69/ÎV70 and D796H conferred modestly decreased sensitivity to convalescent plasma, while maintaining infectivity levels that were similar to the wild-type virus.The spike substitution mutant D796H appeared to be the main contributor to the decreased susceptibility to neutralizing antibodies, but this mutation resulted in an infectivity defect. The spike deletion mutant ÎH69/ÎV70 had a twofold higher level of infectivity than wild-type SARS-CoV-2, possibly compensating for the reduced infectivity of the D796H mutation. These data reveal strong selection on SARS-CoV-2 during convalescent plasma therapy, which is associated with the emergence of viral variants that show evidence of reduced susceptibility to neutralizing antibodies in immunosuppressed individuals