Frequency rate and adjusted risk of maternal morbidity, SGA-birth and spontaneous preterm delivery during second pregnancy in relation to change in BMI between first and second pregnancy, and BMI category at second pregnancy booking.

<p>Frequency rate and adjusted risk of maternal morbidity, SGA-birth and spontaneous preterm delivery during second pregnancy in relation to change in BMI between first and second pregnancy, and BMI category at second pregnancy booking.</p

Average weight change (kg) between first and third pregnancy in relation to BMI classification at baseline (first) and third pregnancy.

<p>Within baseline BMI category columns percentage of women per BMI category at third pregnancy in square brackets.</p

Frequency rate and adjusted risk of maternal morbidity, SGA-birth and spontaneous preterm delivery during third pregnancy in relation to change in BMI between three consecutive pregnancies and BMI category at third pregnancy booking.

<p>Frequency rate and adjusted risk of maternal morbidity, SGA-birth and spontaneous preterm delivery during third pregnancy in relation to change in BMI between three consecutive pregnancies and BMI category at third pregnancy booking.</p

Maternal characteristics, birthweight, placental weight and the incidence of hypertensive disease, caesarean section, thromboembolism, spontaneous preterm delivery, and SGA-birth at first, second and third pregnancy in relation to BMI category at first pregnancy.

<p>Maternal characteristics, birthweight, placental weight and the incidence of hypertensive disease, caesarean section, thromboembolism, spontaneous preterm delivery, and SGA-birth at first, second and third pregnancy in relation to BMI category at first pregnancy.</p

Average weight and BMI change in relation to pattern of BMI-change between first, second and third pregnancy.

<p>Average weight and BMI change in relation to pattern of BMI-change between first, second and third pregnancy.</p

Frequency rate and risk of substantial weight gain or loss (>10kg) in two consecutive inter-pregnancy periods for women with a BMI below or above 25 units at first pregnancy.

<p>Frequency rate and risk of substantial weight gain or loss (>10kg) in two consecutive inter-pregnancy periods for women with a BMI below or above 25 units at first pregnancy.</p

Categorical birth outcomes and their relationship to DNMT variants in babies.

1<p>Variants specified in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0068896#pone-0068896-t001" target="_blank">Table 1</a>. Logistic regression analysis based on all three genotype frequencies (homozygote minor frequency>heterozygote>homozygote common). The standardised birth weight is already adjusted for gestational age and baby sex ²; the risk of requiring neonatal treatment was adjusted for gestational age, baby sex and baby weight ³.</p>*<p><i>p</i><0.05,</p>**<p><i>p</i><0.01,</p>***<p><i>p</i><0.001.</p

Continuous birth outcomes and their relationship to to LINE1, PEG3, SNRPN and IGF2 methylation in cord blood.

<p>Linear regression analysis of DNA methylation on birth parameters. Analyses were adjusted for baby sex, and gestational age ¹ or baby sex alone ².</p>*<p><i>p</i><0.05,</p>**<p><i>p</i><0.01,</p>***<p><i>p</i><0.001.</p

Continuous birth outcomes and their relationship to DNMT variants in mothers and babies.

1<p>Variants specified in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0068896#pone-0068896-t001" target="_blank">Table 1</a>. Linear regression analysis based on all three genotype frequencies (homozygote minor frequency>heterozygote>homozygote common) adjusted for baby sex, and gestational age ² or baby sex alone ³.</p>*<p><i>p</i><0.05,</p>**<p><i>p</i><0.01,</p>***<p><i>p</i><0.001.</p

Proportion of babies in lowest standardised birth weight decile and the proportion requiring neonatal treatment by baby DNMT3L genotype.

<p>Raw data unadjusted for any other variable. Error bars represent 95% confidence intervals.</p