Serological survey of anti-group A rotavirus IgM in UK adults

Rotaviral associated disease of infants in the UK is seasonal and infection in adults not uncommon but the relationship between these has been little explored. Adult sera collected monthly for one year from routine hospital samples were screened for the presence of anti-group A rotavirus immunoglobulin M class antibodies as a marker of recent infection. Anti-rotavirus IgM was seen in all age groups throughout the year with little obvious seasonal variation in the distribution of antibody levels. IgM concentrations and the proportion seropositive above a threshold both increased with age with high concentrations consistently observed in the elderly. Results suggest either high infection rates of rotavirus in adults, irrespective of seasonal disease incidence in infants, IgM persistence or IgM cross-reactivity. These results support recent evidence of differences between infant and adult rotavirus epidemiology and highlight the need for more extensive surveys to investigate age and time related infection and transmission of rotavirus

Changes in lipophorins are related to the activation of phenoloxidase in the haemolymph of Locusta migratoria in response to injection of immunogens

In Locusta migratoria, activation of phenoloxidase in the haemolymph in response to injection of laminarin is age-dependent: being absent in fifth instar nymphs and newly emerged adults, and only becoming evident four days after the final moult. This pattern of change in phenoloxidase activation correlates with the pattern of change in the concentration of apolipophorin-III (apoLp-III) in the haemolymph. Injection of a conspecific adipokinetic hormone (Lom-AKH-I) has no effect on the phenoloxidase response in nymphs or newly emerged adults but, in adults older than four days, co-injection of the hormone with laminarin prolongs the activation of phenoloxidase in the haemolymph: a similar enhancement of the response to laminarin is observed in locusts that have been starved for 48 h but not injected with AKH-I. During most of the fifth stadium, injection of laminarin results in a decrease in the level of prophenoloxidase in the haemolymph; an effect that is not observed in adults of any age. Marked changes in the concentration of apoLp-III, and the formation of LDLp in the haemolymph, are observed after injection of laminarin (or LPS) and these are remarkably similar, at least qualitatively, to those that occur after injection of AKH-I. The involvement of lipophorins in the activation of locust prophenoloxidase in response to immunogens is discussed

Causality and Micro-Causality in Curved Spacetime

We consider how causality and micro-causality are realised in QED in curved spacetime. The photon propagator is found to exhibit novel non-analytic behaviour due to vacuum polarization, which invalidates the Kramers-Kronig dispersion relation and calls into question the validity of micro-causality in curved spacetime. This non-analyticity is ultimately related to the generic focusing nature of congruences of geodesics in curved spacetime, as implied by the null energy condition, and the existence of conjugate points. These results arise from a calculation of the complete non-perturbative frequency dependence of the vacuum polarization tensor in QED, using novel world-line path integral methods together with the Penrose plane-wave limit of spacetime in the neighbourhood of a null geodesic. The refractive index of curved spacetime is shown to exhibit superluminal phase velocities, dispersion, absorption (due to \gamma \to e^+e^-) and bi-refringence, but we demonstrate that the wavefront velocity (the high-frequency limit of the phase velocity) is indeed c, thereby guaranteeing that causality itself is respected.Comment: 16 pages, 11 figures, JHEP3, microcausality now shown to be respected even when the Kramers-Kronig relation is violate

`Superluminal' Photon Propagation in QED in Curved Spacetime is Dispersive and Causal

It is now well-known that vacuum polarisation in QED can lead to superluminal low-frequency phase velocities for photons propagating in curved spacetimes. In a series of papers, we have shown that this quantum phenomenon is dispersive and have calculated the full frequency dependence of the refractive index, explaining in detail how causality is preserved and various familiar results from quantum field theory such as the Kramers-Kronig dispersion relation and the optical theorem are realised in curved spacetime. These results have been criticised in a recent paper by Akhoury and Dolgov arXiv:1003.6110 [hep-th], who assert that photon propagation is neither dispersive nor necessarily causal. In this note, we point out a series of errors in their work which have led to this false conclusion.Comment: 11 page

The F-signature and strong F-regularity

We show that the F-signature of a local ring of characteristic p, defined by Huneke and Leuschke, is positive if and only if the ring is strongly F-regular.Comment: revised version, incorporating referee's comments. 6 page

Bose-Einstein condensate of kicked rotators with time-dependent interaction

A modification of the quantum kicked rotator is suggested with a time-dependent delta-kicked interaction parameter which can be realized by a pulsed turn-on of a Feshbach resonance. The mean kinetic energy increases exponentially with time in contrast to a merely diffusive or linear growth for the first few kicks for the quantum kicked rotator with a constant interaction parameter. A recursive relation is derived in a self-consistent random phase approximation which describes this superdiffusive growth of the kinetic energy and is compared with numerical simulations. Unlike in the case of the quantum rotator with constant interaction, a Lax pair is not found. In general the delta-kicked interaction is found to lead to strong chaotic behaviour.Comment: 4 pages, 3 figure

A concurrent precursor inflow method for Large Eddy Simulations and applications to finite length wind farms

In order to enable simulations of developing wind turbine array boundary layers with highly realistic inflow conditions a concurrent precursor method for Large Eddy Simulations is proposed. In this method we consider two domains simultaneously, i.e. in one domain a turbulent Atmospheric Boundary Layer (ABL) without wind turbines is simulated in order to generate the turbulent inflow conditions for a second domain in which the wind turbines are placed. The benefit of this approach is that a) it avoids the need for large databases in which the turbulent inflow conditions are stored and the correspondingly slow I/O operations and b) we are sure that the simulations are not negatively affected by statically swept fixed inflow fields or synthetic fields lacking the proper ABL coherent structures. Sample applications are presented, in which, in agreement with field data a strong decrease of the power output of downstream wind-turbines with respect to the first row of wind-turbines is observed for perfectly aligned inflow.Comment: 13 pages, 5 figure