Poly[aqua­(μ3-2-hy­droxy-5-nitro­benzoato-κ3 O 1:O 1′:O 2)rubidium]

In the structure of title compound, [Rb(C7H4NO5)(H2O)]n, the centrosymmetric cyclic dimeric repeating unit comprises two irregular RbO4 complex centres bridged by the carboxyl­ate groups of the 5-nitro­salicylate ligands. The coordination about each Rb atom is completed by a monodentate water mol­ecule and a phenolic O-atom donor which gives a bridging extension [Rb—O range = 3.116 (7)–3.135 (5) Å]. The polymeric structure is stabilized by inter­molecular water O—H⋯Ocarboxyl­ate hydrogen bonds and weak inter-ring π–π inter­actions [minimum ring centroid separation = 3.620 (4) Å]. An intramolecular O—H⋯O hydrogen bond between phenol and carboxylate groups is also present

Integrated stratigraphy of the Kimmeridge Clay Formation (Upper Jurassic) based on exposures and boreholes in south Dorset, UK

For the purposes of a high-resolution multi-disciplinary study of the Upper Jurassic Kimmeridge Clay Formation, two boreholes were drilled at Swanworth Quarry and one at Metherhills, south Dorset, UK. Together, the cores represent the first complete section through the entire formation close to the type section. We present graphic logs that record the stratigraphy of the cores, and outline the complementary geophysical and analytical data sets (gamma ray, magnetic susceptibility, total organic carbon, carbonate, [delta]13Corg). Of particular note are the new borehole data from the lowermost part of the formation which does not crop out in the type area. Detailed logs are available for download from the Kimmeridge Drilling Project web-site at http://kimmeridge.earth.ox.ac.uk/. Of further interest is a mid-eudoxus Zone positive shift in the [delta]13Corg record, a feature that is also registered in Tethyan carbonate successions, suggesting that it is a regional event and may therefore be useful for correlation. The lithostratigraphy of the cores has been precisely correlated with the nearby cliff section, which has also been examined and re-described. Magnetic-susceptibility and spectral gamma-ray measurements were made at a regular spacing through the succession, and facilitate core-to-exposure correlation. The strata of the exposure and core have been subdivided into four main mudrock lithological types: (a) medium-dark–dark-grey marl; (b) medium-dark–dark grey–greenish black shale; (c) dark-grey–olive-black laminated shale; (d) greyish-black–brownish-black mudstone. The sections also contain subordinate amounts of siltstone, limestone and dolostone. Comparison of the type section with the cores reveals slight lithological variation and notable thickness differences between the coeval strata. The proximity of the boreholes and different parts of the type section to the Purbeck–Isle of Wight Disturbance is proposed as a likely control on the thickness changes

The Catalina Real-time Transient Survey

The Catalina Real-time Transient Survey (CRTS) currently covers 33,000 deg^2 of the sky in search of transient astrophysical events, with time baselines ranging from 10 minutes to ~7 years. Data provided by the Catalina Sky Survey provides an unequaled baseline against which >4,000 unique optical transient events have been discovered and openly published in real-time. Here we highlight some of the discoveries of CRTS.Comment: To appear in proc. IAU Symp. 285, "New Horizons in Time Domain Astronomy", eds. E. Griffin et al., Cambridge Univ. Press (2012), 3 page

Novel DNA methylation profiles associated with key gene regulation and transcription pathways in blood and placenta of growth-restricted neonates

BB/H012494/1/ Biotechnology and Biological Sciences Research Counci

Shape change and obesity prevalence among male UK offshore workers after 30 years: new insight from a 3D scanning study.

In 1984, male UK offshore workers had higher fat content and greater overweight- and obesity prevalence than the general population. Since then, body weight has increased by 19%, but - without accompanying anthropometric measures - their size increase, current obesity, and fatness prevalence remain unknown. This study therefore aimed to acquire contemporary anthropometric data, to profile changes since the original survey, and to assess current obesity prevalence in the male offshore workforce. A total of 588 men, recruited via quota sampling to match the workforce weight profile, underwent stature, weight, and 3D photonic scanning measurements from which anatomical girths were extracted, enabling computation of body mass index (BMI), total fat, and visceral adipose tissue (VAT). On average, UK male offshore workers are now 8.1 years older, 3.1 cm taller, 13.9 kg heavier, and have greater girths than in 1984, which are > 97% attributable to increased weight, and < 3% to age difference. Mean BMI increased significantly from 24.9 to 28.1 kg/m2 and - of the contemporary sample - 18% have healthy weight, 52% are overweight, and 30% obese, representing an increase in overweight and obesity prevalence by 6% and 24%, respectively. Waist cutoffs identify 39% of the contemporary sample as healthy, 27% at increased health risk, and 34% at high risk. In conclusion, UK offshore workers today have higher BMI than Scottish men, although some muscular individuals may be misclassified by BMI. Girth data, particularly at the waist, where dimensional increase was greatest, together with predictions of total and visceral fatness, suggest less favorable health status in others

Foot health education for people with rheumatoid arthritis : the practitioner's perspective

Background: Patient education is considered to be a key role for podiatrists in the management of patients with rheumatoid arthritis (RA). Patient education has undoubtedly led to improved clinical outcomes, however no attempts have been made to optimise its content or delivery to maximise benefits within the context of the foot affected by rheumatoid arthritis. The aim of this study was to identify the nature and content of podiatrists' foot health education for people with RA. Any potential barriers to its provision were also explored. Methods: A focus group was conducted. The audio dialogue was recorded digitally, transcribed verbatim and analysed using a structured, thematic approach. The full transcription was verified by the focus group as an accurate account of what was said. The thematic analysis framework was verified by members of the research team to ensure validity of the data. Results: Twelve members (all female) of the north west Podiatry Clinical Effectiveness Group for Rheumatology participated. Six overarching themes emerged: (i) the essence of patient education; (ii) the content; (iii) patient-centred approach to content and timing; (iv) barriers to provision; (v) the therapeutic relationship; and (vi) tools of the trade. Conclusion: The study identified aspects of patient education that this group of podiatrists consider most important in relation to its: content, timing, delivery and barriers to its provision. General disease and foot health information in relation to RA together with a potential prognosis for foot health, the role of the podiatrist in management of foot health, and appropriate self-management strategies were considered to be key aspects of content, delivered according to the needs of the individual. Barriers to foot health education provision, including financial constraints and difficulties in establishing effective therapeutic relationships, were viewed as factors that strongly influenced foot health education provision. These data will contribute to the development of a patient-centred, negotiated approach to the provision of foot health education for people with RA

Perceptions Of School By Two Teenage Boys With Asperger Syndrome And Their Mothers: A Qualitative Study

This qualitative study aimed to develop an understanding of the challenges faced by teenage boys with Asperger syndrome and their mothers. A case study approach was used to collect data from two 13-year-old boys who have Asperger syndrome and their mothers in Queensland, Australia. Data were collected through the use of semi¬structured interviews. The words of the boys and their mothers provide a valuable insight into the personal experiences and feelings of the par¬ticipants. An inductive approach to data analysis identified four themes: (1) developmental differences; (2) problems associated with the general characteristics of Asperger syndrome (i.e. communication and social difficulties, restricted range of interests, a need for routine); (3) stress; and (4) 'masquerading'. The first three themes relate strongly to the current literature, but the emergence of masquerading is of particular interest in developing a fuller understanding of the experiences of individuals with Asperger syndrome at school

Effects of periadolescent fluoxetine and paroxetine on elevated plus-maze, acoustic startle, and swimming immobility in rats while on and off-drug

<p>Abstract</p> <p>Rationale</p> <p>Whether selective serotonin reuptake inhibitors (SSRIs) exposure during adolescent brain development causes lasting effects remains unresolved.</p> <p>Objective</p> <p>Assess the effects of fluoxetine and paroxetine 60 days after adolescent exposure compared with when on-drug.</p> <p>Methods</p> <p>Male Sprague-Dawley littermates (41 litters) were gavaged on postnatal days 33-53 with fluoxetine (3 or 10 mg/kg/day), paroxetine (3, 10 or, 17 mg/kg/day), or water; half were tested while on-drug (21 litters) and half after 60 days off-drug (20 litters).</p> <p>Results</p> <p>The highest dose of the drugs reduced body weight gain during treatment that rebounded 1 week post-treatment. On-drug, no significant group differences were found on elevated plus maze time-in-open, zone entries, or latency to first open entry; however, the high dose of paroxetine significantly reduced head-dips (N = 20/group). No significant effects were found on-drug for acoustic startle response/prepulse inhibition (ASR/PPI) although a trend (p < 0.10) was seen, which after combining dose levels, showed a significant increase in ASR amplitude for both fluoxetine and paroxetine (N = 20-21/group). No differences on immobility time were seen in the Porsolt forced swim test or in plasma corticosterone at the end of forced swim (N-19-21/group). Off-drug, no effects were seen in the elevated plus maze (N = 16/group), ASR/PPI (N = 20/group), forced swim (N = 19-20/group), or plasma corticosterone (N = 19/group). At the doses tested, fluoxetine and paroxetine induced minor effects with drug on-board but no residual, long-term adverse effects in rats 60 days after drug discontinuation.</p> <p>Conclusions</p> <p>The data provide no evidence that fluoxetine or paroxetine have long-term adverse effects on the behaviors measured here after adolescent to young adult exposure.</p

Ultra-short Period Binaries from the Catalina Surveys

We investigate the properties of 367 ultra-short period binary candidates selected from 31,000 sources recently identified from Catalina Surveys data. Based on light curve morphology, along with WISE, SDSS and GALEX multi-colour photometry, we identify two distinct groups of binaries with periods below the 0.22 day contact binary minimum. In contrast to most recent work, we spectroscopically confirm the existence of M-dwarf+M-dwarf contact binary systems. By measuring the radial velocity variations for five of the shortest-period systems, we find examples of rare cool-white dwarf+M-dwarf binaries. Only a few such systems are currently known. Unlike warmer white dwarf systems, their UV flux and their optical colours and spectra are dominated by the M-dwarf companion. We contrast our discoveries with previous photometrically-selected ultra-short period contact binary candidates, and highlight the ongoing need for confirmation using spectra and associated radial velocity measurements. Overall, our analysis increases the number of ultra-short period contact binary candidates by more than an order of magnitude.Comment: 12 pages, 12 figures, accepted Ap