Global Plate Motions and Earthquake Cycle Effects

The rotations of tectonic plates provide a partial description of the total observed displacements at the Earth’s surface. The estimated number of kinematically distinct plates has increased from 12 in 1990 to 56 in 2010 as a result of the increase in the number of kinematic observables. At length scales \u3c1,000 km, rotation-only plate models are inaccurate because geodetic signals of long-term plate motions are complicated by earthquake cycle effects. Here we present results from a global block model that unifies large-scale plate motions and local earthquake cycle effects at plate boundaries. Incorporating the rotations of 307 distinct plates, elastic strain accumulation from 16 subduction zones and 1.59×107 km2 of fault system area, this model explains 19,664 interseismic GPS velocities at a resolution of 2.2 mm/year. Geodetically constrained fault slip deficit rates yield a cumulative global moment accumulation rate of 1.09 × 1022 N⋅m/year, 12% larger than the average annual coseismic moment release rate from 1900 to 2013. The potential contribution to the total moment rate budget can be estimated from the frequency distribution of the modeled fault slip-deficit rates, which follow an exponential distribution. Integrating this frequency distribution over all possible slip rates indicates that the geologic structures included in this reference global block model account for 98% of the global moment budget. Comparing our results with population distribution, we find that ∼50% of the world’s population lives within 200 km of an active fault with a slip rate \u3e2 mm/year

A new criteria for zero quantum discord

We propose a new criterion to judge zero quantum discord for arbitrary bipartite states. A bipartite quantum state has zero quantum discord if and only if all blocks of its density matrix are normal matrices and commute with each other. Given a bipartite state with zero quantum discord, how to find out the set of local projectors, which do not disturb the whole state after being imposed on one subsystem, is also presented. A class of two-qubit X-state is used to test the criterion, and an experimental scheme is proposed to realize it. Consequently, we prove that the positive operator-valued measurement can not extinguish the quantum correlation of a bipartite state with nonzero quantum discord.Comment: 10 pages, 1 figur

A Global Set of Subduction Zone Earthquake Scenarios and Recurrence Intervals Inferred From Geodetically Constrained Block Models of Interseismic Coupling Distributions

The past 100 years have seen the occurrence of five (Formula presented.) earthquakes and 94 (Formula presented.) earthquakes. Here we assess the potential for future great earthquakes using inferences of interseismic subduction zone coupling from a global block model incorporating both tectonic plate motions and earthquake cycle effects. Interseismic earthquake cycle effects are represented using a first-order quasistatic elastic approximation and include (Formula presented.) of interacting fault system area across the globe. We use estimated spatial variations in decadal-duration coupling at 15 subduction zones and the Himalayan range front to estimate the locations and magnitudes of potential seismic events using empirical scaling relationships relating coupled area to moment magnitude. As threshold coupling values increase, estimates of potential earthquake magnitudes decrease, but the total number of large earthquakes varies non-monotonically. These rupture scenarios include as many as 14 recent or potential (Formula presented.) earthquakes globally and up to 18 distinct (Formula presented.) events associated with a single subduction zone (South America). We also combine estimated slip deficit rates and potential event magnitudes to calculate recurrence intervals for large earthquake scenarios, finding that almost all potential earthquakes would have a recurrence time of less than 1,000 years

GPS Constraints on the Mw = 7.5 Ometepec Earthquake Sequence, Southern Mexico: Coseismic and Post-Seismic Deformation

We use continuous GPS measurements from 31 stations in southernMexico to model coseismic slip and post-seismic deformation from the 2012 March 20 Mw = 7.5 Ometepec earthquake, the first large thrust earthquake to occur below central Mexico during the modern GPS era. Coseismic offsets ranging from ∼280 mm near the epicentre to 5 mm or less at sites far from the epicentre are fit best by a rupture focused between ∼15 and 35 km depth, consistent with an independent seismological estimate. The corresponding geodetic moment of 1.4 × 1020 N·m is within 10 per cent of two independent seismic estimates. Transient post-seismic motion recorded by GPS sites as far as 300 km from the rupture has a different horizontal deformation gradient and opposite sense of vertical motion than do the coseismic offsets. A forward model of viscoelastic relaxation as a result of our new coseismic slip solution incorrectly predicts uplift in areas where post-seismic subsidence was recorded and indicates that viscoelastic deformation was no more than a few per cent of the measured post-seismic deformation. The deformation within 6 months of the earthquake was thus strongly dominated by fault afterslip. The post-seismic GPS time-series are well fit as logarithmically decaying fault afterslip on an area of the subduction interface up to 10 times larger than the earthquake rupture zone, extending as far as 220 km inland. Afterslip had a cumulative geodetic moment of 2.0 × 1020 N·m, ∼40 per cent larger than the Ometepec earthquake. Tests for the shallow and deep limits for the afterslip require that it included much of the earthquake rupture zone as well as regions of the subduction interface where slow slip events and non-volcanic tremor have been recorded and areas even farther downdip on the flat interface. Widespread afterslip below much of central Mexico suggests that most of the nearly flat subduction interface in this region is conditionally stable and thus contributes measurable transient deformation to large areas of Mexico south of and in the volcanic belt

Cell-selective proteomics for biological discovery

Cells alter the proteome to respond to environmental and developmental cues. Global analysis of proteomic responses is of limited value in heterogeneous environments, where there is no ‘average’ cell. Advances in sequencing, protein labeling, mass spectrometry, and data analysis have fueled recent progress in the investigation of specific subpopulations of cells in complex systems. Here we highlight recently developed chemical tools that enable cell-selective proteomic analysis of complex biological systems, from bacterial pathogens to whole animals

Hepatic ketogenic insufficiency reprograms hepatic glycogen metabolism and the lipidome

While several molecular targets are under consideration, mechanistic underpinnings of the transition from uncomplicated nonalcoholic fatty liver disease (NAFLD) to nonalcoholic steatohepatitis (NASH) remain unresolved. Here we apply multiscale chemical profiling technologies to mouse models of deranged hepatic ketogenesis to uncover potential NAFLD driver signatures. Use of stable-isotope tracers, quantitatively tracked by nuclear magnetic resonance (NMR) spectroscopy, supported previous observations that livers of wild-type mice maintained long term on a high-fat diet (HFD) exhibit a marked increase in hepatic energy charge. Fed-state ketogenesis rates increased nearly 3-fold in livers of HFD-fed mice, a greater proportionate increase than that observed for tricarboxylic acid (TCA) cycle flux, but both of these contributors to overall hepatic energy homeostasis fueled markedly increased hepatic glucose production (HGP). Thus, to selectively determine the role of the ketogenic conduit on HGP and oxidative hepatic fluxes, we studied a ketogenesis-insufficient mouse model generated by knockdown of the mitochondrial isoform of 3-hydroxymethylglutaryl-CoA synthase (HMGCS2). In response to ketogenic insufficiency, TCA cycle flux in the fed state doubled and HGP increased more than 60%, sourced by a 3-fold increase in glycogenolysis. Finally, high-resolution untargeted metabolomics and shotgun lipidomics performed using ketogenesis-insufficient livers in the fed state revealed accumulation of bis(monoacylglycero)phosphates, which also accumulated in livers of other models commonly used to study NAFLD. In summary, natural and interventional variations in ketogenesis in the fed state strongly influence hepatic energy homeostasis, glucose metabolism, and the lipidome. Importantly, HGP remains tightly linked to overall hepatic energy charge, which includes both terminal fat oxidation through the TCA cycle and partial oxidation via ketogenesis

The Earls of Derby and the Early-Modern Performance Culture of North-West England

This special issue of Shakespeare Bulletin is concerned with the 3rd to 7th Earls of Derby, their patronage roles and other involvements in performance cultures in the early-modern period. This forms one central strand of research into the early-modern theatrical history of the small town of Prescot (now in Liverpool City Region's Borough of Knowsley; formerly in south Lancashire). It is this history, and the connections between Knowsley and Shakespearean theatre which it evidences, that inform the current Shakespeare North Playhouse Project, a major, heritage-based, urban regeneration initiative that has been developing for over a decade and which is now coming to fruition. In taking members of the Lancashire-based Stanley dynasty as focalizers of early-modern performance history, this issue addresses under-researched issues of regionality in theatre history. It reverses an older, London-based outlook: by taking Knowsley and Prescot as a viewpoint and looking outwards from north-west England towards other regions, London, and beyond, it adds to work offering new perspectives on the place(s) of theatre in the early-modern period. Lancashire, as it were, writes back to the metropolis here

Understanding context in knowledge translation: a concept analysis study protocol

AimTo conduct a concept analysis of clinical practice contexts (work environments) that facilitate or militate against the uptake of research evidence by healthcare professionals in clinical practice. This will involve developing a clear definition of context by describing its features, domains and defining characteristics.BackgroundThe context where clinical care is delivered influences that care. While research shows that context is important to knowledge translation (implementation), we lack conceptual clarity on what is context, which contextual factors probably modify the effect of knowledge translation interventions (and hence should be considered when designing interventions) and which contextual factors themselves could be targeted as part of a knowledge translation intervention (context modification).DesignConcept analysis.MethodsThe Walker and Avant concept analysis method, comprised of eight systematic steps, will be used: (1) concept selection; (2) determination of aims; (3) identification of uses of context; (4) determination of defining attributes of context; (5) identification/construction of a model case of context; (6) identification/construction of additional cases of context; (7) identification/construction of antecedents and consequences of context; and (8) definition of empirical referents of context. This study is funded by the Canadian Institutes of Health Research (January 2014).DiscussionThis study will result in a much needed framework of context for knowledge translation, which identifies specific elements that, if assessed and used to tailor knowledge translation activities, will result in increased research use by nurses and other healthcare professionals in clinical practice, ultimately leading to better patient care.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111196/1/jan12574.pd

Barriers and supports to implementation of MDI/spacer use in nine Canadian pediatric emergency departments: a qualitative study

<p>Abstract</p> <p>Background</p> <p>Despite recent research supporting the use of metered dose inhalers with spacer devices (MDI/spacers) in pediatric emergency departments (PEDs) for acute exacerbations of asthma, uptake of this practice has been slow. The objectives of this study were to determine the barriers and supports to implementing MDI/spacer research and to identify factors associated with early and late adoption of MDI/spacers in Canadian PEDs.</p> <p>Methods</p> <p>Using a comparative case study design, we classified nine tertiary care pediatric hospital PEDs based on their stage of implementation. Data were collected using focus group interviews with physicians, registered nurses (RNs), and respiratory therapists (RTs), and individual interviews with both patient care and medical directors at each site. Initial coding was based on the Ottawa Model of Research Use (OMRU) categories of elements known to influence the uptake of innovations.</p> <p>Results</p> <p>One hundred and fifty healthcare professionals from nine different healthcare institutions participated in this study. Lack of leadership in the form of a research champion, a lack of consensus about the benefits of MDI/spacers among staff, perceived resistance from patients/parents, and perceived increased cost and workload associated with MDI/spacer use were the most prevalent barriers to the adoption of the MDI/spacer. Common strategies used by early-adopting sites included the active participation of all professional groups in the adoption process in addition to a well-planned and executed educational component for staff, patients, and families. Early adopter sites were also more likely to have the MDI/spacer included in a clinical protocol/pathway.</p> <p>Conclusion</p> <p>Potential barriers and supports to implementation have been identified that will help EDs adopt MDI/spacer use. Future interventions intended to increase MDI/spacer use in PEDs will need to be sensitive to the barriers identified in this study.</p

Lactate signalling regulates fungal β-glucan masking and immune evasion

AJPB: This work was supported by the European Research Council (STRIFE, ERC- 2009-AdG-249793), The UK Medical Research Council (MR/M026663/1), the UK Biotechnology and Biological Research Council (BB/K017365/1), the Wellcome Trust (080088; 097377). ERB: This work was supported by the UK Biotechnology and Biological Research Council (BB/M014525/1). GMA: Supported by the CNPq-Brazil (Science without Borders fellowship 202976/2014-9). GDB: Wellcome Trust (102705). CAM: This work was supported by the UK Medical Research Council (G0400284). DMM: This work was supported by UK National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC/K000306/1). NARG/JW: Wellcome Trust (086827, 075470,101873) and Wellcome Trust Strategic Award in Medical Mycology and Fungal Immunology (097377). ALL: This work was supported by the MRC Centre for Medical Mycology and the University of Aberdeen (MR/N006364/1).Peer reviewedPostprin