3,814 research outputs found
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Vibronic mixing enables ultrafast energy flow in light-harvesting complex II.
Since the discovery of quantum beats in the two-dimensional electronic spectra of photosynthetic pigment-protein complexes over a decade ago, the origin and mechanistic function of these beats in photosynthetic light-harvesting has been extensively debated. The current consensus is that these long-lived oscillatory features likely result from electronic-vibrational mixing, however, it remains uncertain if such mixing significantly influences energy transport. Here, we examine the interplay between the electronic and nuclear degrees of freedom (DoF) during the excitation energy transfer (EET) dynamics of light-harvesting complex II (LHCII) with two-dimensional electronic-vibrational spectroscopy. Particularly, we show the involvement of the nuclear DoF during EET through the participation of higher-lying vibronic chlorophyll states and assign observed oscillatory features to specific EET pathways, demonstrating a significant step in mapping evolution from energy to physical space. These frequencies correspond to known vibrational modes of chlorophyll, suggesting that electronic-vibrational mixing facilitates rapid EET over moderately size energy gaps
Understanding extreme quasar optical variability with CRTS: I. Major AGN flares
There is a large degree of variety in the optical variability of quasars and
it is unclear whether this is all attributable to a single (set of) physical
mechanism(s). We present the results of a systematic search for major flares in
AGN in the Catalina Real-time Transient Survey as part of a broader study into
extreme quasar variability. Such flares are defined in a quantitative manner as
being atop of the normal, stochastic variability of quasars. We have identified
51 events from over 900,000 known quasars and high probability quasar
candidates, typically lasting 900 days and with a median peak amplitude of
mag. Characterizing the flare profile with a Weibull
distribution, we find that nine of the sources are well described by a
single-point single-lens model. This supports the proposal by Lawrence et al.
(2016) that microlensing is a plausible physical mechanism for extreme
variability. However, we attribute the majority of our events to explosive
stellar-related activity in the accretion disk: superluminous supernovae, tidal
disruption events, and mergers of stellar mass black holes.Comment: 25 pages, 18 figures, accepted for publication by MNRA
Dynamic Microclimate Boundaries across a Sharp Tropical Rainforest–Clearing Edge
As landscapes become increasingly fragmented, research into impacts from disturbance and how edges affect vegetation and community structure has become more important. Descriptive studies on how microclimate changes across sharp transition zones have long existed in the literature and recently more attention has been focused on understanding the dynamic patterns of microclimate associated with forest edges. Increasing concern about forest fragmentation has led to new technologies for modeling forest microclimates. However, forest boundaries pose important challenges to not only microclimate modeling but also sampling regimes in order to capture the diurnal and seasonal dynamic aspects of microclimate along forest edges. We measured microclimatic variables across a sharp boundary from a clearing into primary lowland tropical rainforest at La Selva Biological Station in Costa Rica. Dynamic changes in diurnal microclimate were measured along three replicated transects, approximately 30 m in length with data collected every 1 m continuously at 30 min intervals for 24 h with a mobile sensor platform supported by a cable infrastructure. We found that a first-order polynomial fit using piece-wise regression provided the most consistent estimation of the forest edge, relative to the visual edge, although we found no best sensing parameter as all measurements varied. Edge location estimates based on daytime net shortwave radiation had less difference from the visual edge than other shortwave measurements, but estimates made throughout the day with downward-facing or net infrared radiation sensors were more consistent and closer to the visual edge than any other measurement. This research contributes to the relatively small number of studies that have directly measured diurnal temporal and spatial patterns of microclimate variation across forest edges and demonstrates the use of a flexible mobile platform that enables repeated, high-resolution measurements of gradients of microclimate
A systematic search for close supermassive black hole binaries in the Catalina Real-Time Transient Survey
Hierarchical assembly models predict a population of supermassive black hole
(SMBH) binaries. These are not resolvable by direct imaging but may be
detectable via periodic variability (or nanohertz frequency gravitational
waves). Following our detection of a 5.2 year periodic signal in the quasar PG
1302-102 (Graham et al. 2015), we present a novel analysis of the optical
variability of 243,500 known spectroscopically confirmed quasars using data
from the Catalina Real-time Transient Survey (CRTS) to look for close (< 0.1
pc) SMBH systems. Looking for a strong Keplerian periodic signal with at least
1.5 cycles over a baseline of nine years, we find a sample of 111 candidate
objects. This is in conservative agreement with theoretical predictions from
models of binary SMBH populations. Simulated data sets, assuming stochastic
variability, also produce no equivalent candidates implying a low likelihood of
spurious detections. The periodicity seen is likely attributable to either jet
precession, warped accretion disks or periodic accretion associated with a
close SMBH binary system. We also consider how other SMBH binary candidates in
the literature appear in CRTS data and show that none of these are equivalent
to the identified objects. Finally, the distribution of objects found is
consistent with that expected from a gravitational wave-driven population. This
implies that circumbinary gas is present at small orbital radii and is being
perturbed by the black holes. None of the sources is expected to merge within
at least the next century. This study opens a new unique window to study a
population of close SMBH binaries that must exist according to our current
understanding of galaxy and SMBH evolution.Comment: 29 pages, 10 figures, accepted for publication in MNRAS - this
version contains extended table and figur
A possible close supermassive black-hole binary in a quasar with optical periodicity
Quasars have long been known to be variable sources at all wavelengths. Their
optical variability is stochastic, can be due to a variety of physical
mechanisms, and is well-described statistically in terms of a damped random
walk model. The recent availability of large collections of astronomical time
series of flux measurements (light curves) offers new data sets for a
systematic exploration of quasar variability. Here we report on the detection
of a strong, smooth periodic signal in the optical variability of the quasar PG
1302-102 with a mean observed period of 1,884 88 days. It was identified
in a search for periodic variability in a data set of light curves for 247,000
known, spectroscopically confirmed quasars with a temporal baseline of
years. While the interpretation of this phenomenon is still uncertain, the most
plausible mechanisms involve a binary system of two supermassive black holes
with a subparsec separation. Such systems are an expected consequence of galaxy
mergers and can provide important constraints on models of galaxy formation and
evolution.Comment: 19 pages, 6 figures. Published online by Nature on 7 January 201
Pulmonary artery stiffness in chronic obstructive pulmonary disease (copd) and emphysema: The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study
Purpose:
Chronic obstructive pulmonary disease (COPD) and particularly emphysema are characterized by stiffness of the aorta, due in part to accelerated elastin degradation in the lungs and aorta. Stiffness of the pulmonary arteries (PAs) may also be increased in COPD and emphysema, but data are lacking. We assessed PA stiffness using MRI in patients with COPD and related these measurements to COPD severity and percent emphysema.
Materials and Methods:
The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study recruited 290 participants, age 50–79 years with 10 or more packyears and free of clinical cardiovascular disease. COPD severity were defined on postbronchodilator spirometry by ATS/ERS criteria. Percent emphysema was defined as the percentage of regions of the lung < -950 Hounsfield units on full-lung computed tomography (CT). PA stain was defined by the percent change in cross-sectional PA area between systole and diastole on MRI. Blood flow across the tricuspid and mitral valves was assessed by phase-contrast MRI for determination of the ventricular diastolic dysfunction (E/A ratio).
Results:
PA strain was reduced in COPD compared with controls (P = 0.002) and was inversely correlated with COPD severity (P = 0.004). PA strain was inversely associated to percent emphysema (P = 0.01). PA strain was also markedly correlated with right ventricular diastolic dysfunction measured by E/A ratios in the fully adjusted mix models (P = 0.02).
Conclusion:
PA strain is reduced in COPD, related in part to percent emphysema on CT scan, which may have implications for pulmonary small vessel flow and right ventricular function.
Level of Evidence: 2
Technical Efficacy: Stage
Ceria-Engineered Nanomaterial Distribution in, and Clearance from, Blood: Size Matters
AIMS: Characterize different sized ceria-engineered nanomaterial (ENM) distribution in, and clearance from, blood (compared to the cerium ion) following intravenous infusion.
MATERIALS & METHODS: Cerium (Ce) was quantified in whole blood, serum and clot (the formed elements) up to 720 h.
RESULTS: Traditional pharmacokinetic modeling showed best fit for 5 nm ceria ENM and the cerium ion. Ceria ENMs larger than 5 nm were rapidly cleared from blood. After initially declining, whole blood 15 and 30 nm ceria increased (results that have not been well-described by traditional pharmacokinetic modeling). The cerium ion and 5 and 55 nm ceria did not preferentially distribute into serum or clot, a mixture of cubic and rod shaped ceria was predominantly in the clot, and 15 and 30 nm ceria migrated into the clot over 4 h.
CONCLUSION: Reticuloendothelial organs may not readily recognize five nm ceria. Increased ceria distribution into the clot over time may be due to opsonization. Traditional pharmacokinetic analysis was not very informative. Ceria ENM pharmacokinetics are quite different from the cerium ion
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Bidirectional Energy Flow in the Photosystem II Supercomplex
The water-splitting capability of Photosystem II (PSII) of plants and green algae requires the system to balance efficient light harvesting along with effective photoprotection against excitation in excess of the photosynthetic capacity, particularly under the naturally fluctuating sunlight intensity. The comparatively flat energy landscape of the multicomponent structure, inferred from the spectra of the individual pigment-protein complexes and the rather narrow and featureless absorption spectrum, is well known. However, how the combination of the required functions emerges from the interactions among the multiple components of the PSII supercomplex (PSII-SC) cannot be inferred from the individual pigment-protein complexes. In this work, we investigate the energy transfer dynamics of the C2S2-type PSII-SC with a combined spectroscopic and modeling approach. Specifically, two-dimensional electronic-vibrational (2DEV) spectroscopy provides enhanced spectral resolution and the ability to map energy evolution in real space, while the quantum dynamical simulation allows complete kinetic modeling of the 210 chromophores. We demonstrate that additional pathways emerge within the supercomplex. In particular, we show that excitation energy can leave the vicinity of the charge separation components, the reaction center (RC), faster than it can transfer to it. This enables activatable quenching centers in the periphery of the PSII-SC to be effective in removing excessive energy in cases of overexcitation. Overall, we provide a quantitative description of how the seemingly contradictory functions of PSII-SC arise from the combination of its individual components. This provides a fundamental understanding that will allow further improvement of artificial solar energy devices and bioengineering processes for increasing crop yield
Positive Selection by Purified MHC Class II / Thymic Epithelial Cells In Vitro: Costimulatory Signals Mediated by B7 Are Not Involved
We have investigated the possibility that the costimulatory signals required for activation of
mature T cells also play a role in providing differentiation signals for positive selection
during T-cell development. We show that purified MHC Class II+ thymic epithelial cells are
able to support positive selection in vitro but lack both the functional capacity to deliver
costimulatory signals and expression of the costimulatory ligand B7. Our results suggest that
the additional signals provided by costimulatory ligands are not required for TCR-mediated
positive selection, although other ancillary signals provided by thymic epithelial cells may
be involved
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