Synthesis of Substituted Triazole-Pyrazole Hybrids using Triazenopyrazoles Precursors

A synthesis route to access triazole-pyrazole hybrids via pyrazolotriazenes was developed. Contrary to existing methods, this route allows the facile N-functionalization of the pyrazole before the attachment of the triazole unit via a copper-catalyzed azide-alkyne cycloaddition. The developed methodology was used to synthesize a library of over fifty novel multi-substituted pyrazole-triazole hybrids. We could also demonstrate a one-pot strategy that renders the isolation of potentially hazardous azides obsolete. In addition, the compatibility of the method with solid-phase synthesis was shown exemplarily

Supporting Sustainability of Chemistry by Linking Research Data with Physically Preserved Research Materials

Results of scientific work in chemistry can usually be obtained in the form of materials and data. A big step towards transparency and reproducibility of the scientific work can be gained if scientists publish their data in a FAIR (Findable, Accessible, Interoperable, Reusable) manner in research data repositories. Nevertheless, in order to make chemistry as a discipline sustainable, obtaining FAIR data is insufficient and a comprehensive concept including the preservation of materials is needed. We describe in this article how we combined two infrastructures, a repository for research data (Chemotion repository) and an archive for chemical compounds (Molecule Archive), in order to offer a comprehensive infrastructure to find and access data and materials that were generated in chemistry projects. Samples play a key role in this concept: we describe how FAIR metadata of a virtual sample representation can be used to refer to the physically available sample stored in a materials’ archive and to link FAIR research data gained with the sample. We further describe the measures to make the physically available samples not only FAIR through the sample’s metadata but also accessible and reusable in the form of their material for others