Some Epistemological and Methodological Problems of Holistic Biological Modeling, Biosimilarity Identification and Complex Interpretation of the Origin of Life

This article considers the novel approach for epistemological interpretation of biomimetics or bionics and biosimilarity in different abiogenetic works with the terminological correction for elimination of the reifications (concretisms, hypostatizations), simplified metaphors and the results of metonymy. In the last part of this article one can see the analysis of the mistakes and problems of complex abiogenetic or supramolecular evolution projects within the aspects of the Conway law and the social organization of science and publishing sphere in subjective postmodern capitalistic conditions

BIOCOMPATIBLE BIOMIMETIC POLYMER STRUCTURES WITH AN ACTIVE RESPONSE FOR IMPLANTOLOGY AND REGENERATIVE MEDICINE PART I: BASIC PRINCIPLES OF THE ACTIVE IMPLANT’S BIOCOMPATIBILITY

Physical and chemical criteria of biocompatibility of the active polymer implants and stimuli-responsive scaffolds are considered. From the standpoint of the surface physics and controlled wetting, the possibilities of dynamic control of biocompatibility and adaptive changes in the implant properties in response to the signal from the surrounding tissues are considered. The basic properties of the active biocompatible and biomimetic implantable materials, which distinguish them from the passive implants, are summarized. The latter include: electrophysical and electrophysiological membrane biocompatibility (up to the analogy with biomembranes – the so-called Fendler’s “membrane mimetics”); excitability, that is, the ability to qualitatively change their state in response to the external stimulus; compatibility of the matching parameters and impedances of biomembranes and active implantable materials; the presence of the main types of the energy conversion characteristic of biomembranes (chemiosmotic, electrochemical, electromechanical, etc.); the ability to transport and release pharmaceuticals consistent with the parameters of the cellular microenvironment and regulated by its state. Due to the qualitative change in the biomedical aim of such implants (from replacing the natural function to its regeneration and maintenance), there is a possibility of implementing various new biologically relevant functions using these materials, such as the ability to sensing and actuation, based on their reactivity and signal / energy conversion capacity. Of particular interest is the adaptive realization of the above functions in a growing and developing organism during its ontogenesis

Dune system waveform evolution simulation on the terylene substances using Olson's dynamical analogies, similarity criteria and dimensional analysis

It is well known that sand waves are formed by the action of either wind or water (through the waves or tidal currents). Modeling of the evolution of tidal sand waves is the basis of marine and river dune dynamics. Both the river dunes and tidal sand waves are generated by the same physical mechanisms. Hence, it is possible to simulate such phenomena using uniform or similar equations, which can be explicated not only for the linear scales, but also for nonlinear systems and non-stationary boundary conditions. Morphodynamic modeling of tidal sand waves is usually performed using computer software algorithms, but the aim of our work is realization of direct physical modeling of tidal sand waves based on chemically different media using several hydrodynamical / hydraulical similarity criteria and principles of the unified interpretation of the wave phenomena in the framework of nonlinear physics. We also use the scaling principles for microscopic simulation of the effects observed on the mesoscopic and “macroscopic” levels (sensu lato), for direct observation of them at the microscopic level using complex electron microscopy instrumentation