The Iowa Homemaker vol.1, no.10

Table of Contents The “Why” and “How” of Meal Planning by Beth Bailey, page 1 Confessions of a Trained Aunt by Eda Lord Murphy, page 2 Keeping House at the Practice Cottage by Millie Lerdall, page 3 How to Judge of a Pattern by Nira Klise, page 4 Iowa State College Women Are Modern Marketers by Katherine Goeppinger, page 5 A Simple System of Household Accounting by Genevieve McKim Barker, page 6 For Those Who Have Difficulties in Home Dyeing by Grace McIlrath, page

The Iowa Homemaker vol.1, no.7

Table of Contents The Yea and Nay of Newspaper Work for Women by Helen Easter, page 1 Facts About the Feeding of Young Children by Belle Lowe, page 2 An Inventory of Skill for the Honest Homewife by Elizabeth Storm, page 3 Who Waits on Your Table? by Beth Bailey, page 4 My First Flight in the Pursuit of Beauty by Eda Lord Murphy, page 4 A New Cure for the “Run-Down” Housewife by Carrie Plunkett, page 5 A Pattern in Hot Lunch Service for Rural Schools by Grace McIlrath, page 6 The Reason for the Addled Egg by C. H. Plunkett, page 7 Short Cuts in Sewing by Helen Easter, page 1

The Iowa Homemaker vol.1, no.8

Table of Contents An Appreciation of the Life of Dean MacKay compiled by Clara Jordan, page 1 Iowa Members of W. C. T. U. Meet by Helen Paschal, page 2 What Shall We Have for Thanksgiving Dinner? by Beth Bailey, page 3 Things to Know About the School Lunch Basket by Millie Lerdall and Grace McIlrath, page 4 Do You Know What’s In a Can? by Blanche Ingersoll, page 5 “La Chambre D’Ami” in An Iowa Home by Eda Lord Murphy, page 6 “Looking In” on Home Economics at Iowa State by An Alumna, page 6 Pumpkin Pies They Don’t Forget by Viola M. Bell, page

The Iowa Homemaker vol.1, no.5-6

Table of Contents Dean MacKay Takes Well Earned Vacaion by F. W. Beckman, page 1 Playing the Game of Health With Yardstick and Scales by Grace McIlrath and Gladys Dodge, page 2 A Parent-Teacher Association in Every School! by Carolyne E. Forgrave, page 3 Artificial Feeding of Infants Up-to-Date by Belle Lowe, page 4 Making the Most of Your Old Reed Furniture by Glenna Hesse, page 5 The “Little House” That You Will Like by Helen Paschal, page 6 “The High School Girls’ Clothes Line” a Playlet, page 7 Practical Phases of the Love Nest by Eda Lord Murphy, page 8 Putting the Jell Into Jellies and Jams by Millie Lerdall, page

Carotid axillary bypass in a patient with blocked subclavian stents: a case report

<p>Abstract</p> <p>Introduction</p> <p>Surgical treatment of symptomatic occlusive lesions of the proximal subclavian artery is infrequently necessary. Carotid subclavian bypass has gained popularity and is now considered standard treatment when stenting is not possible. Exposure of the subclavian artery and bypass grafting onto it is difficult, as the vessel is delicate, thin-walled and located deep in the supraclavicular fossa. The thoracic duct and brachial plexus are in close proximity to the left subclavian artery and are therefore susceptible to damage. Distal grafting to the axillary artery instead of the subclavian artery has the potential of avoiding some of these risks. Infraclavicular exposure of the axillary artery is more straightforward. The vessel wall is thicker and is easier to handle. In this case report, we describe a patient with a left proximal subclavian occlusion which was stented twice and blocked on both occasions. The patient underwent a carotid axillary bypass, as grafting onto the subclavian artery was impossible because of the two occluded metal stents.</p> <p>Case presentation</p> <p>A 56-year-old Caucasian woman, a heavy smoker, presented acutely with left arm numbness and pain and blood pressure discrepancies in both arms. A diagnosis of subclavian stenosis was confirmed on the basis of a computed tomographic scan and a magnetic resonance angiogram. The patient had undergone subclavian artery stenting twice, and unfortunately the stents blocked on both occasions. The patient underwent carotid axillary bypass surgery. She had an uneventful recovery and was able to return to a full, normal life.</p> <p>Conclusion</p> <p>Carotid axillary bypass appears to be a good alternative to carotid subclavian bypass in the treatment of symptomatic proximal stenosis or occlusion of the subclavian artery.</p

Blood RNA analysis can increase clinical diagnostic rate and resolve variants of uncertain significance

Purpose: Diagnosis of genetic disorders is hampered by large numbers of variants of uncertain significance (VUSs) identified through next-generation sequencing. Many such variants may disrupt normal RNA splicing. We examined effects on splicing of a large cohort of clinically identified variants and compared performance of bioinformatic splicing prediction tools commonly used in diagnostic laboratories. Methods: Two hundred fifty-seven variants (coding and noncoding) were referred for analysis across three laboratories. Blood RNA samples underwent targeted reverse transcription polymerase chain reaction (RT-PCR) analysis with Sanger sequencing of PCR products and agarose gel electrophoresis. Seventeen samples also underwent transcriptome-wide RNA sequencing with targeted splicing analysis based on Sashimi plot visualization. Bioinformatic splicing predictions were obtained using Alamut, HSF 3.1, and SpliceAI software. Results: Eighty-five variants (33%) were associated with abnormal splicing. The most frequent abnormality was upstream exon skipping (39/85 variants), which was most often associated with splice donor region variants. SpliceAI had greatest accuracy in predicting splicing abnormalities (0.91) and outperformed other tools in sensitivity and specificity. Conclusion: Splicing analysis of blood RNA identifies diagnostically important splicing abnormalities and clarifies functional effects of a significant proportion of VUSs. Bioinformatic predictions are improving but still make significant errors. RNA analysis should therefore be routinely considered in genetic disease diagnostics.This article is freely available via Open Access. Click on the Publisher URL to access it via the publisher's site.This research was funded by National Institute for Health Research (NIHR) and the NewLife Foundation. The Baralle lab is supported by NIHR Research Professorship to D.B. (RP-2016-07-011).published version, accepted version (6 month embargo), submitted versio

Solo status and women's spatial test performance: the role of individuation tendencies

The impact of anticipated solo status on women's spatial performance was investigated in an experimental study. The study was designed to test whether the underperformance of women entering testing situations who find themselves to be the only woman present is related to a tendency to individuate the self. Women performed a test of spatial ability under conditions of anticipated solo or non-solo status and responded to a measure of self-construal. In line with previous research, we found a disrupting solo status effect on women's performance on the spatial ability test. Most importantly, the negative effect of solo status on performance was partially mediated by individuation tendencies as reflected in a decreased predominance of the interdependent (as compared to the independent) level of the self under solo status conditions. These findings indicate that individuation tendencies play a crucial role in the process triggered in test takers under threatening performance situations. Copyright © 2007 John Wiley & Sons, Ltd.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/60972/1/490_ftp.pd

Bostonia. Volume 7

Founded in 1900, Bostonia magazine is Boston University's main alumni publication, which covers alumni and student life, as well as university activities, events, and programs

Protective effect of leptin against ischemia-reperfusion injury in the rat small intestine

BACKGROUND: The small intestine is extremely sensitive to ischemia-reperfusion (I/R) injury and a range of microcirculatory disturbances which contribute to tissue damage. Previous studies have shown that leptin plays an important physiological role in the microvasculature. The aim of this study was to evaluate the protective effects of leptin in I/R – induced mucosal injury in the small intestine. METHODS: Forty rats were divided into 5 groups (n = 8). Group I was subjected to a sham operation. Following mesenteric ischemia in group II (control); physiologic saline 1 cm(3), in group III; leptin 100 μg/kg, and physiologic saline 1 cm(3), in group IV; N(G)-L-arginine methyl ester (L-NAME) 20 mg/kg, and physiologic saline 1 cm(3), in group V; leptin 100 μg/kg, L-NAME 20 mg/kg, and physiologic saline 1 cm(3 )were given intra-peritoneally. In these groups, an I/R procedure was performed by occlusion of the superior mesenteric artery for 45 min followed by 120 min reperfusion. After reperfusion, the small intestines were resected for malondialdehyde (MDA) and nitric oxide (NO) concentration and histopathologic properties. Mucosal lesions were scored between 0 and 5. Tissue MDA and NO concentration and histopathologic grades were compared statistically. RESULTS: Tissue MDA level significantly increased (P < 0.05), tissue NO level significantly decreased in group V animals, compared to group III animals respectively (P < 0.001). Histopathologically, intestinal injury significantly decreased in the leptin treated ischemic group. CONCLUSION: Leptin can be used safely in mesenteric occlusive diseases, since it induces NO formation and release in mesenteric vessels