Farmacomorbiditeitskoppeling in een Nederlands ziekenhuis: Nieuwe mogelijkheden voor farmaco-epidemiologisch onderzoek

Pharmacoepidemiological and pharmacoeconomical studies reveal important information about the relationship between disease and drug consumption and therefore about efficacy, safety and costs of pharmacotherapeutic treatment. Our study demonstrates that we have been able to link 99.4% of in-patient medication records with the patient's diagnostic data from the Dutch National Information System on Hospital Care. Patients were admitted for an acute myocardial infarction (ICD-9M: 410) in Medisch Centrum Haaglanden-Antoniushove (Leidschendam, The Netherlands) in 1994 and 2000. Our results show that in particular medication in the treatment of an acute myocardial infarction is incompletely registered in our hospital pharmacy. After adjusting for the missing information, the use of specific cardiovascular drugs shows a positive influence on the outcome of the treatment of an acute myocardial infarction

Identification of first-stage labor arrest by electromyography in term nulliparous women after induction of labor

Contains fulltext : 174756.pdf (publisher's version ) (Closed access)INTRODUCTION: Worldwide induction and cesarean delivery rates have increased rapidly, with consequences for subsequent pregnancies. The majority of intrapartum cesarean deliveries are performed for failure to progress, typically in nulliparous women at term. Current uterine registration techniques fail to identify inefficient contractions leading to first-stage labor arrest. An alternative technique, uterine electromyography has been shown to identify inefficient contractions leading to first-stage arrest of labor in nulliparous women with spontaneous onset of labor at term. The objective of this study was to determine whether this finding can be reproduced in induction of labor. MATERIAL AND METHODS: Uterine activity was measured in 141 nulliparous women with singleton term pregnancies and a fetus in cephalic position during induced labor. Electrical activity of the myometrium during contractions was characterized by its power density spectrum. RESULTS: No significant differences were found in contraction characteristics between women with induced labor delivering vaginally with or without oxytocin and women with arrested labor with subsequent cesarean delivery. CONCLUSION: Uterine electromyography shows no correlation with progression of labor in induced labor, which is in contrast to spontaneous labor