Evaluering av regionale miljøprogram. Vurdering av ordningene ”avrenning til vassdrag og plantevernmidler”

I denne rapporten er det foretatt en evaluering av tilskuddsordningene ”avrenning til vassdrag og plantevernmidler ” som del av regionale miljøprogram. Det er sammenlignet ordningene fra 2003 ved felles nasjonale tilskuddsordninger med ordningene etablert i regionale miljøprogram for 2006. Evalueringen sammenligner likheter og ulikheter i utformingen av ordningene, gjennomføringsgrad og beregnete miljøeffekter. […]publishedVersio

The Scavenger Receptor Cysteine-Rich (SRCR) Domain: An Ancient and Highly Conserved Protein Module of the Innate Immune System.

The Scavenger Receptor Cysteine-Rich (SRCR) domain is an ancient and highly conserved protein module of ~100−110 amino acids, which defines a superfamily (SRCR-SF) of either soluble or membrane-bound receptors expressed by hematopoietic and nonhematopoietic cells, at either embryonic or adult stages. The existence of two types of SRCR domains allows the division of the SRCR-SF into two groups. Members of group A contain SRCR domains with 6 cysteine residues and are encoded by two exons, whereas those of group B usually contain 8 cysteines and are encoded by a single exon. Group A members usually present as multidomain mosaic proteins containing single SRCR domains associated to other functional domains, such as enzymatic (protease) domains or collagenous regions. On the contrary, group B members generally present as proteins exclusively composed of tandem repeats of SRCR domains, with or without the presence of CUB and ZP domains thought to be involved in oligomerization but never associated to protease domains. Representatives of either group are found in different animal species, from low invertebrates (sponges) to high vertebrates (mammals). Although no unifying function has been defined for SRCR-SF members, accumulated data, together with the high degree of structural and phylogenetic conservation of SRCR domains indicates that they might subserve basic homeostatic functions, including innate immune defense