93 research outputs found

    Multicomponent reactions in PEG-400: ruthenium-catalyzed synthesis of substituted pyrroles

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    International audienceAn efficient and eco-friendly method for the synthesis of substituted pyrroles has been developed via ruthenium-catalyzed multicomponent reaction of ketone, amine, and ethylene glycol in PEG-400 as solvent medium without using any external ligand. The catalytic system and solvent can be recycled with the same, as well as different, ketones with minimum loss of Ru-catalyst activity

    New syntheses and uses of acylsilanes

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    International audienc

    Design, Synthesis and Biological Evaluation for Analogues of Bioactive Biarylic Polyphenols

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    Effect of fluorine or oxygen atom(s) in propargylic position on the reactivity in click chemistry

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    International audienceThe use of especially designed ω-diynes allows to establish, through competitive reactions, the effect of C-F, C-OH, CF2, Cdouble bond; length as m-dashO and C(OMe)2 substituents on the reactivity of neighbouring triple bonds in click chemistry and this gives not only a reactivity scale but also a direct access to the difference in activation energies between the competitive reaction pathways

    Development of the Meyer Schuster Rearrangement on Propargylic Alcohols with Fluorinated Chains.

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    International audienceThe Meyer‐Schuster Rearrangement (MSR) is a challenging process for propargylic alcohols bearing fluorine atom(s) on their chains. Most classical reagents/catalysts failed to perform MSR but, after extensive screening, we demonstrated that phosphomolybdic acid was the first efficient catalyst with such derivatives. scope and limitations have been studied, affording fluorine‐containing enones as useful intermediates synthesis of targets fluorine(s) side It exemplified by preparation 2‐piperidino‐pyrimidine pyrazole

    Indium-catalyzed Friedel-Crafts alkylation of monosubstituted benzenes by 1-bromoadamantane

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    Recent Developments in the Meyer-Schuster Rearrangement

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    International audienceA century after its discovery, the Meyer-Schuster rearrangement appears as a very useful method to prepare α,ÎČ-unsaturated carbonyl derivatives. This comprehensive review highlights the progress of this reaction during the last decade focusing on the new catalysts, the novel cascade reactions, the brilliant applications in total synthesis of natural products, and the first examples of aza-Meyer-Schuster rearrangement
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