4-Bromo­methyl-7-methyl-6,8-dinitro­coumarin

The crystal structure of the title compound, C11H7BrN2O6, establishes the substitution positions of the nitro groups from the nitration reaction of 7-methyl-4-bromo­methyl coumarin. The mean planes of the nitro groups form dihedral angles of 43.9 (8) and 52.7 (10)° with the essentially planar [maximum deviation 0.031 (6) Å] benzopyran ring system

Purification and characterization of a myotoxic phospholipase-a2 from indian cobra (Naja-Naja-Naja) venom

Purification and characterization of a myotoxic phospholipase A2 from Indian cobra (Naja naja naja) venom. Toxicon27, 861–873, 1989.—A major phospholipase A2 (NN-XIII-PLA2) which constitutes 20% of the whole Naja naja naja venom was purified to homogeneity on CM-Sephadex C-25 column chromatography. NN-XIII-PLA2 is a basic protein with a mol. wt of 11,200 by SDS-PAGE. This enzyme has low enzymatic activity but is more toxic to mice than the whole venom. The ld50 value (i.p.) of NN-XIII-PLA2 is 2.4 mg/kg body weight (whole venoms ld50 is 2.8 mg/kg body weight). It induces neurotoxic-like signs in experimental animals. It induces myotoxicity when injected i.m. into the thigh muscle of mice and edema when injected into the foot pads of mice. This enzyme has a fluorescence maxima between 310–316 nm which is typical of tyrosine residues

Parameterizaion – Simulation – Optimization Approach for Reservoir Operation

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv

Dyeing of silk using Madhuca longifolia as natural dye source

The dried leaves of Madhuca longifolia has been evaluated for their potential as a source for natural dyeing of silk. Dye has been extracted under optimum conditions such as extraction pH (10), time (60 min) and temperature (95̊°C). The extracted dye has been applied on the silk fabrics and a range of shades are obtained using different methods with or without using mordants. It is found that mordants have a significant effect on the color of dyed silk fabrics. The dyed samples have been evaluated for color measurements and standard wash, light and rub fastness tests. The extracted dye is also tested for some of the eco-parameters using atomic absorption spectrophotometry and GC/MS. The test results are compared with set standards to determine the eco-friendliness of natural dye. Their concentrations are found to be lower than the stipulated limits. The dyed samples are also tested for antimicrobial activity against Gram-positive and Gram-negative bacteria. The dyed silk fabrics show acceptable fastness properties and are found to possess antibacterial activity. The results show that Madhuca longifolia leaves are promising as a natural colorant, which would, in turn, pave the way for the discovery of a new range of environment-friendly dyes for textile materials

Genetic diversity study in tropical carrot (Daucus carota L.)

Genetic diversity study was conducted at ICAR- Indian institute of Horticultural Research, Bengaluru during 2018-19. In this study, 80 accessions were evaluated for 16 yield and yield attributing traits. The Mahalanobis’ D2 analysis grouped these accessions into seven clusters. Cluster I was the largest with 69 genotypes followed by cluster III comprising six genotypes while, the clusters II, IV, V, VI and VII contained one genotype each. Among the traits studied, yield contributed maximum (38.04 %) towards diversity, followed by root weight (26.58%), root color (9.18%) and plant height (6.7%). As far as root weight (g) [d1], leaf weight (g), root weight (g), number of leaves, TSS(°Brix), leaf weight (g), root diameter (mm), core diameter (mm), and root cracking are concerned, they contributed 3.45, 2.09, 1.77, 1.71, 1.55, 1.52, 1.46, 1.33, 1.01 and 0.82 percent respectively. Diversity analysis has given an indication about the genetic variation among the carrot accessions which will prove useful in selection of diverse parents in crop improvement programme

Varate Giduga (Acc. No. 21067; IC No. 418238) : A unique mango (Mangifera indica L.) variety

Varate Giduga is one of the unique variety from Sirsi region of Karnataka. The tree is Semi-circular shaped with dense foliage, leaves about 25cm long; dark green in colour with wavy margin. It is a very consistent and heavy producer. The fruit of this tree matures by mid-April and fruit has a distinctive yellow skin color on fruit exposed to the sun. The fruit shape is round, fruit weight ranged from 350-400 g, fruit length was 9.8 cm, fruit diameter was 9.2 cm, fruit thickness was 8.0cm and bisexual flowers were 16.53%. Biochemical constituents such as the total phenols (317.50 mg/100 g), flavonoids (5.79 mg/100g), carotenoids (1.46 mg/100 g) and acidity (0.19%) were recorded which suggests that these characters are unique as compared to other varieties. The fruit skin is rough and glossy in appearance and the fruit has little or no fiber. It is very delicious in taste with high pulp percentage (74.0%) and high TSS (23.4º B). The flesh color is orange. The fruits have deep orange firm pulp and very sweet with pleasant flavor. Besides,several other traits have drawn special attention to this mango variety as it has large sized fruits (Fig-1), late variety with very good taste, fruit can be cut into two halves by retaining the stone in one half, regular bearer and fruit fly resistant genotype because of its thick peel and high phenolic content in pulp (317.50 mg/100 g)

Research Paper

Ph.D. Research paperNot AvailableNot Availabl

RECENT TRENDS IN MANAGEMENT OF KERATOCONJUNCTIVITIS SICCA (DRY EYE DISEASE)

At the air-water interface, the tear film lipid layer (TFLL), a combination of lipids and proteins plays an important role in surface tension of the tear and is necessary for the physiological hydration of the ocular surface and maintenance of ocular homeostasis. Alteration in lacrimal fluid rheology, differences in lipid constitution or down regulation of particular tear proteins are found in maximum types of ocular surface disease including dry eye disease (DED). Dry eye is a disorder of the tear film due to tear deficiency or excessive tear evaporation, which causes damage to the interpalpebral ocular surface and is associated with symptoms of discomfort. It results in changes on the ocular surface epithelia causing reduced tear quantity and surface sensitivity which leads to inflammation reactions. Managing this inflammation is very helpful in dry eye disease patients. In this article we revise the current understanding of tear film properties, ocular surface and review the effectiveness of topically applied tear supplements, thermo sensitive atelocollagen punctal plug, subtrasal ultrasonic transducers, novel liposome based gelling tear formation and insulin based ophthalmic delivery systems which help in restoring the healthy tear film

Morphological characterization and genetic barcoding of kuttiatoor mango accessions

A survey conducted during 2013-14 to collect and characterize the Kuttiattoor mango accessions from Kerala, revealed large unique variability in morphological, biochemical and DNA barcode data. All the accessions were polyembryonic with fruit maturity during February-March. The mature fruit length (cm), width (cm) and leaf length (cm) ranged from 5.10 – 9.60 (cm), 4.60 – 8.40 (cm) and 12.47- 30.40 (cm) respectively

4-(4-Chloro­phen­yl)-N-[(E)-4-(dimethyl­amino)­benzyl­idene]-1,3-thia­zol-2-amine

The title compound, C18H16ClN3S, adopts an extended mol­ecular structure. The thia­zole ring is inclined by 9.2 (1) and 15.3 (1)° with respect to the chloro­phenyl and 4-(dimethyl­amino)­phenyl rings, respectively, while the benzene ring planes make an angle of 19.0 (1)°. A weak inter­molecular C—H⋯π contact is observed in the crystal structure