An elusive case of acute abdomen in dengue fever

Currently dengue is endemic in all continents except Europe and epidemic dengue hemorrhagic fever occurs in Asia. Hemorrhagic manifestations observed at every stage of illness, they are probably the summation of ill understood virus as well as host factors that result in the incompetence of vescular endothelium

4-Bromo­methyl-7-methyl-6,8-dinitro­coumarin

The crystal structure of the title compound, C11H7BrN2O6, establishes the substitution positions of the nitro groups from the nitration reaction of 7-methyl-4-bromo­methyl coumarin. The mean planes of the nitro groups form dihedral angles of 43.9 (8) and 52.7 (10)° with the essentially planar [maximum deviation 0.031 (6) Å] benzopyran ring system

Synthesis of rhodium(III) complexes with tris/tetrakis-benzimidazoles and benzothiazoles - quick identification of cyclometallation by nuclear magnetic resonance spectroscopy

Reactions of rhodium(III) halides with multidentate N, S-heterocycles, (LH3) 1,3,5-tris(benzimidazolyl)benzene (L1H3; 1), 1,3,5-tris(N-methylbenzimidazolyl) benzene (L2H3; 2) and 1,3,5-tris(benzothiazolyl)benzene (L3H3; 3), in the molar ratio 1 : 1 in methanol-chloroform produced mononuclear cyclometallated products of the composition RhX2 (LH2)(H2O) (X = Cl, Br, I; LH2 = L1H2, L2H 2, L3H2). When the metal to ligand (1-3 or 1,2,4,5-tetrakis(benzothiazolyl)benzene L4H2; 4) molar ratio was 2 : 1, the reactions yielded binuclear complexes of the compositions Rh2Cl5 (LH2)(H2O) 3 (LH2 = L1H2, L2H2, L 3H2) and Rh2X4 (L 4)(H2O) 2 (X= Cl, Br, I). Elemental analysis, IR and 1H nuclear magnetic resonance (NMR) chemical shifts supported the binuclear nature of the complexes. Cyclometallation was detected by conventional 13C NMR spectra that showed a doublet around �190 ppm. Cyclometallation was also detected by gradient-enhanced heteronuclear multiple bond correlation (g-HMBC) experiment that showed cross-peaks between the cyclometallated carbon and the central benzene ring protons of 1-3. Cyclometallation was substantiated by two-dimensional 1H- 1H correlated experiments (gradiant-correlation spectroscopy and rotating frame Overhauser effect spectroscopy) and 1H-13C single bond correlated two-dimensional NMR experiments (gradient-enhanced heteronuclear single quantum coherence). The 1H-15N g-HMBC experiment suggested the coordination of the heterocycles to the metal ion via tertiary nitrogen. © 2009 John Wiley & Sons, Ltd

Reactions of organo-rhodium complexes with multidentate N,N and N,S-heterocycles and exchange studies by NMR

Dihalobridged binuclear complexes Rh(diolefin)(μ-X)2 {diolefin = 1,5-cyclooctadiene (cod), X = Cl or Br; diolefin = norbornadiene (nbd), X = Cl}, undergo halide bridge cleavage reactions with multidentate N,N-heterocycles 1,3,5-tris(benzimidazolyl)benzene (L1H3), 1,3,5-tris(N-methylbenzimidazolyl)benzene (L2H3) and N,S-heterocycle 1,3,5-tris(benzothiazolyl)benzene (L3H3) to yield trinuclear heterocycle bridged complexes {RhX(cod)}3(μ-LH3) and {RhCl(nbd)}3(μ-LH3) (LH3 = L1H3, L2H3, L3H3). 1H NMR exchange measurements have shown resonances for olefinic protons 1â³, 2â³, 5â³ and 6â³ of cod at different chemical shifts, perhaps due to restricted Rh-N bond rotation. The olefinic and aliphatic protons would undergo exchange with each other and also with intermediate species. The exchange mechanism may be visualized to involve Rh-N bond breaking, rotation of the cod ligand of the T-shaped (three-coordinate) intermediate species followed by recomplexation. An alternate mechanism may be Rh-cod bond breaking at olefin positions 5â³ and 6â³, isomerisation of the T-complex such that 5â³/6â³ moves trans to X coupled with rotation of the heterocycle about the Rh-N bond (made easier by the reduced coordination number of the intermediate), followed by recoordination of 1â³/2â³ trans to N, followed by recomplexation. NMR signals from the intermediate species in one dimensional 1H, 13C and 2D NMR spectra have supported the exchange of protons. © 2009 Elsevier Ltd. All rights reserved

Spectrophotometric Determination of Ru(III) with Promazine Hydrochloride

477-47

Rapid Spectrophotometric Determination of Ce(IV), As(III) & Nitrite with Promethazine Hydrochloride

763-76

Development of Intermediate-Moisture Slices of Papaya (Carica papaya L.) by Hurdle Technology

Papaya fruits are highly perishable, with over 25% post-harvest losses which further rise during storage. To prevent these losses, we attempted to convert papaya slices into intermediate moisture (IM) slices using a novel combination-technology which included a combination of osmotic removal of water by sugar syrup (60°B) containing various preservatives/additives, and, added use of chemicals such as CaCl2, citric acid, sodium metabisulphite or potassium metabisulphite (KMS), to reduce water activity. The osmosed slices were surfacedried and analyzed for physico-chemical characters and sensory attributes. Further, the product was stored upto six months at LT (Low Temperature) (4±1°C) and assessed for composition, stability and sensory attributes. Steam blanching of papaya slices, followed by osmosis in sugar solution of 60°B syrup containing a combination of preservatives, viz., citric acid 0.5%, CaCl2 0.5%, sodium metabisulphite 75ppm and KMS 350ppm, was superior as a treatment in terms of quality and stability of the product. These findings can help reduce postharvest losses in papaya by providing a technology for preparing a ready-to-eat (RTE), nutrient rich intermediate-moisture product with good taste and flavour