Utilisation of trash fish. Pt. 1. Preparation of fish flake

The paper deals with the investigations carried out on the preparation of odorless fish-starch flakes using partially deodorized trash fish meat and different sources of starch like corn, tapioca, maida and black gram. It has been found that the products using corn and tapioca are better compared to those prepared using other two starches, the product from corn being the best. The product has a protein content of about 20% and has been found to have a storage life of 4 months at 37°c

GResilient index to assess the greenness and resilience of the automotive supply chain

Purpose: The purpose of this paper is to suggest an Index entitled GResilient Index to assess the greenness and resilience of the automotive companies and corresponding supply chain. Design/methodology/approach: An integrated assessment model is proposed based on Green and Resilient practices. These practices are weighted according to their importance to the automotive supply chain competitiveness. The Delphi technique is used to obtain the weights for the focused supply chain paradigms and corresponding practices. The model is then tested using a case study approach in the automotive supply chain. Findings: The case study results confirmed the applicability of this Index in a real-world supply chain. The results show that the Resilient supply chain management paradigm is the one considered as the one that more contributes for the automotive supply chain competitiveness. Research limitations/implications: The proposed Index was developed in the automotive sector context therefore it could not be adjusted to a different one. Future research could consider other aggregation methods for the Index construction. Practical implications: Supply chain participants will be able to evaluate the performance of their companies or supply chain in terms of Green and Resilient paradigms. Also, the Index can be effectively employed for functional benchmarking among competing companies and supply chains.Green; resilient; supply chain management; index; automotive industry

Stability of Cubic Functional Equation in Random Normed Space

In this paper, we present the Hyers-Ulam stability of Cubic functional equation. where n is greater than or equal to 4, in Random Normed Space

Utility of Different Electrocardiographical Leads during Diagnostic Ajmaline Test for Suspected Brugada Syndrome

In order to compare the value of different leads and lead combinations to detect the signature Brugada type ECG pattern, we analysed digital 10-second, 15-lead ECGs (12 standard leads + leads V1 to V3 from 3rd intercostal (i.c.) space, V1h to V3h) acquired during diagnostic Ajmaline testing in 128 patients (80 men, age 37±15 years) with suspected Brugada syndrome (BS) (patient group), 15-lead resting ECGs of 108 healthy subjects (53 men, age 31.9±10.5 years) (control group A) and standard 12-lead resting ECGs of 229 healthy subjects (111 men, age 33±4 years) (control group B). Bipolar leads between V2 (positive pole) and V4 or V5 (leads V2-4V2-5) were derived by subtracting leads V4 and V5 from V2 (custom-made program). The 6 peripheral, 6 right precordial leads (V1 to V3, V1h to V3h) and leads V2-4 and V2-5 of the patients group, leads V1h to V3h of control group A, and leads V2-4 and V2-5 of control group B were analysed for the presence of type 1 Brugada pattern. There were 21 (16.4%) positive and 107 (83.6%) negative Ajmaline tests. In 7 positive tests (33%), type 1 pattern appeared only in leads V1h to V3h, whereas in 14 tests 67%) it appeared in both V1 to V3 and V1h to V3h. Lead V2 displayed type 1 pattern during 10 positive tests; in all of them, plus 10 other positive tests type 1 was also noted in lead V2h (n=20, 95.2%). In all 10 cases, in which lead V2 exhibited type 1 pattern (n=10), lead V2-4 and/or V2-5 also exhibited type 1-like pattern. During 7 positive tests, in which lead V2h but not V2 exhibited type 1 pattern, lead V2-4 and/or V2-5 also demonstrated type 1 pattern. Type 1 pattern was observed in leads V3 and V3h during 1 (5%) and 5 (24%) positive tests, in 0 ECGs (0%) in control group A and in 1 ECG (0.4%) in control group B. In conclusion, the "high" V1 and V2 leads (3rd i.c. space) detect more sensitively Brugada type 1 pattern than the standard V1 and V2 leads (4th i.c. space); leads V3 and V3h are not essential for the diagnosis of BS; bipolar leads V2-4 and V2-5 are superior to lead V2 for the ECG diagnosis of BS

Role of thrombophilia screening in recurrent pregnancy loss and poor pregnancy outcome

Background: The pathophysiology of recurrent pregnancy loss is poorly understood and some factors have been implicated as causes of RPL including genetics, metabolic and infections. But still in majority of RPL cases, cause remains unexplained (around 40-50%). Recent few studies have shown that there is significant association between thrombophilia and RPL. The genetic predisposition to venous thrombosis such as factor V Leiden, factor V HR2 haplotype, factor V HongKong/Cambridge and PAI-1 4G/5G promoter polymorphism have been reported to be associated with RPL. This study examined the specific prevalence of genetic thrombophilic markers in women with recurrent miscarriage.Methods: A retrospective case-control study designed with 50 RPL cases and 50 healthy controls. Genotyping of the four thrompohilic mutation were performed by PCR-RFLP and AS-PCR methods.Results: The frequencies of factor V HR2 haplotype mutant heterozygous form (OR=1.46; p=0.758), PAI-1-675 4G/4G (OR=1.13; p=0.806) and PAI-1 -675 5G/5G (OR=1.24; p=0.815) were moderately higher in RPL patients than controls. While, the mutant form of factor V Hong Kong and factor V Cambridge were completely absent in this study population.Conclusions: To our best knowledge, this is the first study to investigate the association of Factor V HR2 haplotype, factor V Hong Kong/Cambridge and PAI-1 (-675 4G/5G) mutations with RPL in South Indian population. However, this study did not reveal any significant association between studied mutations and RPL due to small sample size

Stable Polyglutamine Dimers Can Contain β-Hairpins with Interdigitated Side Chains But Not α-Helices, β-Nanotubes, β-Pseudohelices, or Steric Zippers

AbstractA common thread connecting nine fatal neurodegenerative protein aggregation diseases is an abnormally expanded polyglutamine tract found in the respective proteins. Although the structure of this tract in the large mature aggregates is increasingly well described, its structure in the small early aggregates remains largely unknown. As experimental evidence suggests that the most toxic species along the aggregation pathway are the small early ones, developing strategies to alleviate disease pathology calls for understanding the structure of polyglutamine peptides in the early stages of aggregation. Here, we present a criterion, grounded in available experimental data, that allows for using kinetic stability of dimers to assess whether a given polyglutamine conformer can be on the aggregation path. We then demonstrate that this criterion can be assessed using present-day molecular dynamics simulations. We find that although the α-helical conformer of polyglutamine is very stable, dimers of α-helices lack the kinetic stability necessary to support further oligomerization. Dimers of steric zipper, β-nanotube, and β-pseudohelix conformers are also too short-lived to initiate aggregation. The β-hairpin-containing conformers, instead, invariably form very stable dimers when their side chains are interdigitated. Combining these findings with the implications of recent solid-state NMR data on mature fibrils, we propose a possible pathway for the initial stages of polyglutamine aggregation, in which β-hairpin-containing conformers act as templates for fibril formation

The persistent nucleus: atoms, power and energy policy discourse in the anthropocene

Despite economic debacles, recurring “accidents”, reactor core meltdowns in Chernobyl and Fukushima and the cautious academic reflection it has engendered, civilian nuclear power continues to enjoy legitimacy in energy policy discourse. This may not be the case in all countries. But it is so in a number of influential states, such as, prominently, all the permanent members of the UN Security Council. Why does nuclear power persist in these and other key countries, such as India or Iran and Japan? How is it that economic costs, technology risks and weapons proliferation concerns point in one direction while energy policy and technology choice moves in the other? We suggest that for an important set of select countries this divergence can be ascribed to a “discourse of power” that is pegged to domestic concerns and, more importantly, to international relations. This discursive process constructs energy and material abundance as the cornerstone of social stability, political power and ultimately national sovereignty and geopolitical influence. The atom’s energy remains prominent in such imaginaries of abundance, more so in contexts of fossil energy insecurity and climate change. The questioning then of nuclear power by environmental and social concerns has to also question this discourse of power. The latter’s sanguinity vis-a-vis abundant energy needs to be problematised. This is not the case today in international relations. Practitioners focus on the consequences of environmental deterioration. The problem of climate refugees, for example. This paper argues that realist frames of power and self-interest in international relations be acknowledged explicitly as drivers of the discourse of power and in turn the socio-ecological consequences that ensue from this pursuit of cheap and abundant energy. To challenge nuclear power ultimately is to also challenge this medieval yet dominant norm of power play that pervades large swathes of international relations