Foundations Supporting Research and Innovation in Europe: Results and Lessons From the Eufori Study

This article presents the most important results of the European Foundation for Research and Innovation Study, the first study to map the roles and collective contributions of Europe’s large, heterogeneous, and fragmented sector of research and innovation foundations. The study, based on a review of about 1,000 foundations, estimates that they contribute at least $6.4 billion a year to research and innovation in Europe. While this estimate shows that the contribution is quite substantial, its economic weight is modest compared to that of government, the business sector, and other actors in the domain of research and innovation. European foundations prefer to describe their relationship with other actors as complementary. But foundations play an important role as innovative risk takers, and have greater flexibility than government and the business sector to support projects in underdeveloped areas. The various players in the domain of research have their own distinctive roles; together, they can make a difference in increasing the potential for research and innovation in Europe

Identification of molluscan nicotinic acetylcholine receptor (nAChR) subunits involved in formation of cation- and anion-selective nAChRs

Acetylcholine (ACh) is a neurotransmitter commonly found in all animal species. It was shown to mediate fast excitatory and inhibitory neurotransmission in the molluscan CNS. Since early intracellular recordings, it was shown that the receptors mediating these currents belong to the family of neuronal nicotinic acetylcholine receptors and that they can be distinguished on the basis of their pharmacology. We previously identified 12 Lymnaea cDNAs that were predicted to encode ion channel subunits of the family of the neuronal nicotinic acetylcholine receptors. These Lymnaea nAChRs can be subdivided in groups according to the residues supposedly contributing to the selectivity of ion conductance. Functional analysis in Xenopus oocytes revealed that two types of subunits with predicted distinct ion selectivities form homopentameric nicotinic ACh receptor (nAChR) subtypes conducting either cations or anions. Phylogenetic analysis of the nAChR gene sequences suggests that molluscan anionic nAChRs probably evolved from cationic ancestors through amino acid substitutions in the ion channel pore, a mechanism different from acetylcholine-gated channels in other invertebrates

Giving in Evidence: Fundraising from philanthropy for research funding in European universities

his report (in which I declare an interest as co-author) presents the results of the first large-scale study of philanthropic funding in European universities, both for general purposes, and specifically in support of research. It covers individual donors, charitable trusts and foundations and private corporations, analysing the wide range of contextual and institutional factors affecting success and failure in fundraising from philanthropic sources. It also explores the distribution of efforts and outcomes of fundraising activities, ways in which philanthropic contributions are used to support research, and the positive and negative impacts of receiving this source of funding. The wealth of data gathered through this study provides a much-needed basis for any future enquiries in the field of fundraising from philanthropy for research in European universities