Clinical presentation, neuroimaging findings, and predictors of brain parenchymal lesions in cerebral vein and dural sinus thrombosis: A retrospective study

Introduction: Cerebral venous sinus thrombosis (CVST) is an unusual cause of stroke with potentially serious consequences. This study was designed to investigate the clinical and neuroimaging features in patients with CVST and to analyze the predictors of brain parenchymal lesions. Materials and Methods: A retrospective study of 181 patients with CVST was conducted in a tertiary care hospital. Results: Of 181 patients (age range 14–96 years, mean age: 34.64 ± 14.66 years), 121 were female (66.9%). Most of the patients were in their third decade of life. Headache (47.51%) was the most common clinical presentation followed by seizures (24.31%). Transverse sinus (TS) (77.9%) was the most common site of venous sinus thrombosis. Brain parenchymal lesions were present in 63%, and each patient had subarachnoid and intraventricular hemorrhage. Hemorrhagic venous infarct was the most common brain parenchymal lesion (37.57%). Frontal region (25.4%) was the most common site of brain parenchymal lesions followed by frontoparietal region (21.9%). Women were more likely to have brain parenchymal lesions (72.4%, P= 0.034). Headache was the most common clinical presentation in patients without brain parenchymal lesions while seizures with brain parenchymal lesions. Straight sinus thrombosis was more likely to be associated with brain parenchymal lesions (P = 0.009). Conclusion: CVST presents in young and more commonly in females. TS was the most common site of venous sinus thrombosis. Female gender, seizures, altered sensorium and focal neurological deficit at presentation, and straight sinus thrombosis were more likely associated with the presence of brain parenchymal lesions

Assessing pollution and health risks from chromite mine tailings contaminated soils in India by employing synergistic statistical approaches

Potentially toxic elements (PTEs) contamination in the agricultural soil can generate a detrimental effect on the ecosystem and poses a threat to human health. The present work evaluates the PTEs concentration, source identification, probabilistic assessment of health hazards, and dietary risk analysis due to PTEs pollution in the region of the chromite-asbestos mine, India. To evaluate the health risks associated with PTEs in soil, soil tailings and rice grains were collected and studied. The results revealed that the PTEs concentration (mainly Cr and Ni) of total, DTPA-bioavailable, and rice grain was significantly above the permissible limit in site 1 (tailings) and site 2 (contaminated) as compared with site 3 (uncontaminated). The Free ion activity model (FIAM) was applied to detect the solubility of PTEs in polluted soil and their probable transfer from soil to rice grain. The hazard quotient values were significantly higher than the safe (FIAM-HQ \u3c 0.5) for Cr (1.50E+00), Ni (1.32E+00), and, Pb (5.55E+00) except for Cd (1.43E−03), Cu (5.82E−02). Severity adjustment margin of exposure (SAMOE) results denote that the PTEs contaminated raw rice grain has high health risk [CrSAMOE: 0.001; NiSAMOE: 0.002; CdSAMOE: 0.007; PbSAMOE: 0.008] for humans except for Cu. The Positive matrix factorization (PMF) along with correlation used to apportion the source. Self-organizing map (SOM) and PMF analysis identified the source of pollution mainly from mines in this region. Monte Carlo simulation (MCS) revealed that TCR (total carcinogenic risk) cannot be insignificant and children were the maximum sufferers relative to adults via ingestion-pathway. In the spatial distribution map, the region nearer to mine is highly prone to ecological risk with respect to PTEs pollution. Based on appropriate and reasonable evaluation methods, this work will help environmental scientists and policymakers\u27 control PTEs pollution in agricultural soils near the vicinity of mines

The Terminal Heat Stress and its Effect on Yield and Yield Contributing Traits of Wheat (Triticum aestivum L.) Genotypes

An experiment was conducted with wheat genotypes NWL-14, K-9162, NWL-1014, NWL-12-2, NWL-12-4, NWL-10-4, K-910-30, NWL-4035, DBW-16, DBW-187, NWL-12 (3) T, Halna, HD-2967 to evaluate heat tolerant in wheat at instructional farm and in the laboratory of Crop Physiology & Plant Molecular Biology and Genetic Engineering, Acharya Narendra Deva University of Agriculture and Technology, Kumarganj, Ayodhya, India, during rabi season of 2021-2022. Heat stress was induced by delayed sowing 45 days from normal date of sowing (02 December 2022)-(17 January 2023) so that delay sown wheat genotypes could experience heat stress at reproductive stage. Heat tolerant wheat genotypes screened on the basis of Relative Water Content, Catalase activity, plant height, tiller number, number of grains per spike, test weight and grain yield per plant over control under heat stress condition. Heat stress reduces the the growth and yield irrespective of wheat genotypes but heat tolerant genotypes Halna, NWL-1293)T, NWL 10-2 and NWL-12-4 showed less reduction over susceptible ones. Relative water content, proline and catalase activity can be used as a physiological screening indices for heat tolerant genotypes