SUBLINGUAL VITAMIN D3 DRUG THERAPY IN VITAMIN D DEFICIENCY PATIENTS AT PRAVARA RURAL HOSPITAL

The present study was aimed to study the effect of Sublingual Vitamin D3 on Serum Vitamin D level in Vitamin D deficiency patients. This was a cross-sectional and interventional study. All the Vitamin D deficiency patients of age 18-60years and either gender, willing to participate in the study were included. Patients who had greater than 20 ng/ml were excluded from the study. The total number of participants in our study was 200, out of these 111 males and 89 females, the mean age in our study was 51.07 ± 7.39Yrs. All volunteers were given sublingual vitamin D3 (60,000IU) in six doses every fifteen days of follow up for 3 months. The subject’s serum 25(OH)D levels were estimated before and after the treatment of sublingual vitamin D3. There was a statistically significant difference in serum vitamin D3 level before 16.61±6.71 ng/ml and after 35.80±7.80 ng/ml after treatment with Sublingual Vitamin D3. Six doses of 60,000IU of Vitamin D3 sublingual route having improved the role of serum 25(OH)D levels in the treatment of Vitamin D3 deficiency patients.Keywords: Vitamin D3; Sublingual rout

SUBLINGUAL VITAMIN D3 DRUG THERAPY IN VITAMIN D DEFICIENCY PATIENTS AT PRAVARA RURAL HOSPITAL

The present study was aimed to study the effect of Sublingual Vitamin D3 on Serum Vitamin D level in Vitamin D deficiency patients. This was a cross-sectional and interventional study. All the Vitamin D deficiency patients of age 18-60years and either gender, willing to participate in the study were included. Patients who had greater than 20 ng/ml were excluded from the study. The total number of participants in our study was 200, out of these 111 males and 89 females, the mean age in our study was 51.07 ± 7.39Yrs. All volunteers were given sublingual vitamin D3 (60,000IU) in six doses every fifteen days of follow up for 3 months. The subject’s serum 25(OH)D levels were estimated before and after the treatment of sublingual vitamin D3. There was a statistically significant difference in serum vitamin D3 level before 16.61±6.71 ng/ml and after 35.80±7.80 ng/ml after treatment with Sublingual Vitamin D3. Six doses of 60,000IU of Vitamin D3 sublingual route having improved the role of serum 25(OH)D levels in the treatment of Vitamin D3 deficiency patients.Keywords: Vitamin D3; Sublingual rout

Effect of atorvastatin and rosuvastatin on 25-hydroxy vitamin d levels in newly diagnosed South Indian dyslipidemic subjects: A randomized, open-label, single center study

Background: Statins are one of the mainstay treatment modality for the people suffering from dyslipidemia. Statins reduce the cholesterol bio-synthesis by ß-hydroxy-ß-methyl glutaryl Co-A (HMG-CoA) reductase inhibition which is rate-limiting enzyme. It also affects the Vit-D levels as metabolism of cholecalciferol and cholesterol are interrelated. Objectives: Effect of atorvastatin/ rosuvastatin on 25-hydroxy Vitamin-D (25OHD) concentrations among subjects with newly diagnosed dyslipidemia. Materials and Methods: Prospective randomized, open-label, parallel group study. Lipid and 25OHD levels are measured at baseline and end of 6 months after statin treatment. One group received atorvastatin and another study group received rosuvastatin for 6 months. Results: Mean 25OHD concentrations are 32.0±4.7, 31.7±4.8 and 32.9±4.9 in the control, atorvastatin and rosuvastatin groups respectively. Both atorvastatin and rosuvastatin groups, except TGs, all the lipid parameters and 25OHD has showed significant difference (<0.001) from baseline to end-line repeated parameters. All the study participants were well tolerated and no one discontinued the drug due to drug-related adverse reactions. Conclusion: Participants with atorvastatin treated group showed significant reduction in 25OHD concentrations. In addition, 25OHD concentrations are dependent on statin efficacy