2,935 research outputs found
The Genetic Basis of Mutation Rate Variation in Yeast.
Mutations are the root source of genetic variation and underlie the process of evolution. Although the rates at which mutations occur vary considerably between species, little is known about differences within species, or the genetic and molecular basis of these differences. Here, we leveraged the power of the yeast Saccharomyces cerevisiae as a model system to uncover natural genetic variants that underlie variation in mutation rate. We developed a high-throughput fluctuation assay and used it to quantify mutation rates in seven natural yeast isolates and in 1040 segregant progeny from a cross between BY, a laboratory strain, and RM, a wine strain. We observed that mutation rate varies among yeast strains and is heritable (H 2 = 0.49). We performed linkage mapping in the segregants and identified four quantitative trait loci underlying mutation rate variation in the cross. We fine-mapped two quantitative trait loci to the underlying causal genes, RAD5 and MKT1, that contribute to mutation rate variation. These genes also underlie sensitivity to the DNA-damaging agents 4NQO and MMS, suggesting a connection between spontaneous mutation rate and mutagen sensitivity
Generalizations of Weighted Trapezoidal Inequality for Monotonic Mappings and Its Applications
In this paper, we establish some generalizations of weighted trapezoid inequality for monotonic mappings, and give several applications for r − moment, the expectation of a continuous random variable and the Beta mapping
Bimetric varying speed of light theories and primordial fluctuations
We exhibit a varying speed of light (VSL) theory that implements the recently
proposed decaying speed of sound mechanism for generating density fluctuations.
We avail ourselves of bimetric VSL theories, where the speed of gravity differs
from that of light. We first show that a Dirac-Born-Infeld (DBI) type of
-essence has the necessary speed of sound profile to produce (near)
scale-invariant fluctuations. We then examine the map between bimetric and
-essence models: typically the bi-scalar connecting the two metrics is a
-essence field in one of them. Remarkably, the DBI model is found to
perturbatively represent the minimal bimetric model, where the bi-scalar is
Klein-Gordon in the matter frame. But the full non-perturbative bimetric
structure is even simpler: the bi-scalar dynamics should be simply driven by a
cosmological constant in the matter frame, balanced by an opposite cosmological
constant in the gravity frame. Thus the problem of structure formation receives
an elegant and universal solution within bimetric VSL theories, which are known
to also solve the flatness and entropy problems and evade a plethora of
causality concerns
Equilibrium vortex formation in ultrarapidly rotating two-component Bose-Einstein condensates
Equilibrium vortex formation in rotating binary Bose gases with a rotating
frequency higher than the harmonic trapping frequency is investigated
theoretically. We consider the system being evaporatively cooled to form
condensates and a combined numerical scheme is applied to ensure the binary
system being in an authentic equilibrium state. To keep the system stable
against the large centrifugal force of ultrafast rotation, a quartic trapping
potential is added to the existing harmonic part. Using the Thomas-Fermi
approximation, a critical rotating frequency \Omega_c is derived, which
characterizes the structure with or without a central density hole. Vortex
structures are studied in detail with rotation frequency both above and below
?\Omega_c and with respect to the miscible, symmetrically separated, and
asymmetrically separated phases in their nonrotating ground-state counterparts.Comment: 7 pages, 7 figure
GRB Afterglows from Anisotropic Jets
Some progenitor models of gamma-ray bursts (GRBs) (e.g., collapsars) may
produce anisotropic jets in which the energy per unit solid angle is a
power-law function of the angle (). We calculate light
curves and spectra for GRB afterglows when such jets expand either in the
interstellar medium or in the wind medium. In particular, we take into account
two kinds of wind: one () possibly from a typical red
supergiant star and another () possibly from a Wolf-Rayet
star. We find that in each type of medium, one break appears in the late-time
afterglow light curve for small but becomes weaker and smoother as
increases. When , the break seems to disappear but the afterglow decays
rapidly. Thus, one expects that the emission from expanding, highly anisotropic
jets provides a plausible explanation for some rapidly fading afteglows whose
light curves have no break. We also present good fits to the optical afterglow
light curve of GRB 991208. Finally, we argue that this burst might arise from a
highly anisotropic jet expanding in the wind () from a red
supergiant to interpret the observed radio-to-optical-band afterglow data
(spectrum and light curve).Comment: 12 pages + 10 figures, accepted by Ap
Dynamical Equilibration Across a Quenched Phase Transition in a Trapped Quantum Gas
The formation of an equilibrium quantum state from an uncorrelated thermal
one through the dynamical crossing of a phase transition is a central question
of non-equilibrium many-body physics. During such crossing, the system breaks
its symmetry by establishing numerous uncorrelated regions separated by
spontaneously-generated defects, whose emergence obeys a universal scaling law
with the quench duration. Much less is known about the ensuing re-equilibrating
or "coarse-graining" stage, which is governed by the evolution and interactions
of such defects under system-specific and external constraints. In this work we
perform a detailed numerical characterization of the entire non-equilibrium
process, addressing subtle issues in condensate growth dynamics and
demonstrating the quench-induced decoupling of number and coherence growth
during the re-equilibration process. Our unique visualizations not only
reproduce experimental measurements in the relevant regimes, but also provide
valuable information in currently experimentally-inaccessible regimes.Comment: Supplementary Movie Previes: SM-Movie-1: https://youtu.be/3q7-CvuBylg
SM-Movie-2: https://youtu.be/-Gymaiv9rC0 SM-Movie-3:
https://youtu.be/w-O2SPiw3nE SM-Movie-4: https://youtu.be/P4xGyr4dwK
- …