Selective flow-injection determination of aniline and m-nitroaniline in mixtures containing isomeric nitroanilines and aniline

Operating conditions for the selective flow-injection determination of aniline and 3-nitroaniline in the presence of isomeric nitroanilines as 5,7-dichloro-4,6-benzofuroxan derivatives of test compounds are determined by varying the flow composition. The analytical range is 0.35-17.5 μg/mL for aniline and 1.5-30 μg/mL for 3-nitroaniline. The detection limit of aniline in the presence of nitroanilines is as low as 0.2 μg/mL. © 1998 MAEe cyrillic signK Hayκa/Interperiodica Publishing

Reversed-phase liquid chromatographic determination of isoniazide in human urine as a test of the genetically predetermined type of biotransformation by acetylation

A new method of determination of genetically predetermined type of biotransformation by acetylation rate using reversed-phase liquid chromatography (RP-HPLC) was described. The method is based on determination of isonicotinic hydrazide (INH) which is excreted with the patient's urine during 24 h period after oral administration of 0.4 g of the drug. INH is used as pharmacogenetic marker. Precolumn derivatization of 4-chloro-5,7- dinitrobenzofurazan is used at RP-HPLC determination of INH and a new drug phosphabenzide (diphenylphosphinylacetic hydrazide, DPPAH) with spectrophotometric detection in urine. The limit of INH detection was 0.27 μg ml-1 and the one of DPPAH was 0.82 μg ml-1. As a result of pharmacokinetic investigation it was discovered that bimodal distribution by acetylation rate for DPPAH is less apparent than in the case of INH. It is shown, that immunomodulator xymedone (N-(β-oxyethyl)-4,6- dimethyldihydropirimidon-2) is the acetylation inductor of xenobiotics

Electronic structure, linear, nonlinear optical susceptibilities and birefringence of CuInX2 (X = S, Se, Te) chalcopyrite-structure compounds

The electronic structure, linear and nonlinear optical properties have been calculated for CuInX2 (X=S, Se, Te) chalcopyrite-structure single crystals using the state-of-the-art full potential linear augmented plane wave (FP-LAPW) method. We present results for band structure, density of states, and imaginary part of the frequency-dependent linear and nonlinear optical susceptibilities. We find that these crystals are semiconductors with direct band gaps. We have calculated the birefringence of these crystals. The birefringence is negative for CuInS2 and CuInSe2 while it is positive for CuInTe2 in agreement with the experimental data. Calculations are reported for the frequency-dependent complex second-order non-linear optical susceptibilities . The intra-band and inter-band contributions to the second harmonic generation increase when we replace S by Se and decrease when we replace Se by Te. We find that smaller energy band gap compounds have larger values of in agreement with the experimental data and previous theoretical calculations.Comment: 17 pages, 6 figure

Selective flow-injection determination of aniline and m-nitroaniline in mixtures containing isomeric nitroanilines and aniline

Operating conditions for the selective flow-injection determination of aniline and 3-nitroaniline in the presence of isomeric nitroanilines as 5,7-dichloro-4,6-benzofuroxan derivatives of test compounds are determined by varying the flow composition. The analytical range is 0.35-17.5 μg/mL for aniline and 1.5-30 μg/mL for 3-nitroaniline. The detection limit of aniline in the presence of nitroanilines is as low as 0.2 μg/mL. © 1998 MAEe cyrillic signK Hayκa/Interperiodica Publishing

Selective flow-injection determination of aniline and m-nitroaniline in mixtures containing isomeric nitroanilines and aniline

Operating conditions for the selective flow-injection determination of aniline and 3-nitroaniline in the presence of isomeric nitroanilines as 5,7-dichloro-4,6-benzofuroxan derivatives of test compounds are determined by varying the flow composition. The analytical range is 0.35-17.5 μg/mL for aniline and 1.5-30 μg/mL for 3-nitroaniline. The detection limit of aniline in the presence of nitroanilines is as low as 0.2 μg/mL. © 1998 MAEe cyrillic signK Hayκa/Interperiodica Publishing

Selective flow-injection determination of aniline and m-nitroaniline in mixtures containing isomeric nitroanilines and aniline

Operating conditions for the selective flow-injection determination of aniline and 3-nitroaniline in the presence of isomeric nitroanilines as 5,7-dichloro-4,6-benzofuroxan derivatives of test compounds are determined by varying the flow composition. The analytical range is 0.35-17.5 μg/mL for aniline and 1.5-30 μg/mL for 3-nitroaniline. The detection limit of aniline in the presence of nitroanilines is as low as 0.2 μg/mL. © 1998 MAEe cyrillic signK Hayκa/Interperiodica Publishing

Reversed-phase liquid chromatographic determination of isoniazide in human urine as a test of the genetically predetermined type of biotransformation by acetylation

A new method of determination of genetically predetermined type of biotransformation by acetylation rate using reversed-phase liquid chromatography (RP-HPLC) was described. The method is based on determination of isonicotinic hydrazide (INH) which is excreted with the patient's urine during 24 h period after oral administration of 0.4 g of the drug. INH is used as pharmacogenetic marker. Precolumn derivatization of 4-chloro-5,7- dinitrobenzofurazan is used at RP-HPLC determination of INH and a new drug phosphabenzide (diphenylphosphinylacetic hydrazide, DPPAH) with spectrophotometric detection in urine. The limit of INH detection was 0.27 μg ml-1 and the one of DPPAH was 0.82 μg ml-1. As a result of pharmacokinetic investigation it was discovered that bimodal distribution by acetylation rate for DPPAH is less apparent than in the case of INH. It is shown, that immunomodulator xymedone (N-(β-oxyethyl)-4,6- dimethyldihydropirimidon-2) is the acetylation inductor of xenobiotics

Reversed-phase liquid chromatographic determination of isoniazide in human urine as a test of the genetically predetermined type of biotransformation by acetylation

A new method of determination of genetically predetermined type of biotransformation by acetylation rate using reversed-phase liquid chromatography (RP-HPLC) was described. The method is based on determination of isonicotinic hydrazide (INH) which is excreted with the patient's urine during 24 h period after oral administration of 0.4 g of the drug. INH is used as pharmacogenetic marker. Precolumn derivatization of 4-chloro-5,7- dinitrobenzofurazan is used at RP-HPLC determination of INH and a new drug phosphabenzide (diphenylphosphinylacetic hydrazide, DPPAH) with spectrophotometric detection in urine. The limit of INH detection was 0.27 μg ml-1 and the one of DPPAH was 0.82 μg ml-1. As a result of pharmacokinetic investigation it was discovered that bimodal distribution by acetylation rate for DPPAH is less apparent than in the case of INH. It is shown, that immunomodulator xymedone (N-(β-oxyethyl)-4,6- dimethyldihydropirimidon-2) is the acetylation inductor of xenobiotics

Reversed-phase liquid chromatographic determination of isoniazide in human urine as a test of the genetically predetermined type of biotransformation by acetylation

A new method of determination of genetically predetermined type of biotransformation by acetylation rate using reversed-phase liquid chromatography (RP-HPLC) was described. The method is based on determination of isonicotinic hydrazide (INH) which is excreted with the patient's urine during 24 h period after oral administration of 0.4 g of the drug. INH is used as pharmacogenetic marker. Precolumn derivatization of 4-chloro-5,7- dinitrobenzofurazan is used at RP-HPLC determination of INH and a new drug phosphabenzide (diphenylphosphinylacetic hydrazide, DPPAH) with spectrophotometric detection in urine. The limit of INH detection was 0.27 μg ml-1 and the one of DPPAH was 0.82 μg ml-1. As a result of pharmacokinetic investigation it was discovered that bimodal distribution by acetylation rate for DPPAH is less apparent than in the case of INH. It is shown, that immunomodulator xymedone (N-(β-oxyethyl)-4,6- dimethyldihydropirimidon-2) is the acetylation inductor of xenobiotics