SCREENING FOR HEPATITIS C Response from Hepatitis C Trust, BASL, BIA, BVHG, BSG, and BHIVA to article asking whether widespread screening for hepatitis C is justified

This is the peer reviewed published version of the following article: Response from Hepatitis C Trust, BASL, BIA, BVHG, BSG, and BHIVA to article asking whether widespread screening for hepatitis C is justified, which has been published in final form at 10.1136/bmj.h998. This article may be used for non-commercial purposes in accordance with BMJ's Terms and Conditions for Self-Archiving.This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/ by/4.0

Who’s Who in That Picture? The Association between Profile Picture Content and Social Well-Being

Despite significant interest in social well-being and its association with Facebook use, research on profile picture content has been overlooked. The current study asked participants (n = 158) to log into their Facebook account, access their profile pictures, and categorize the content of their profile pictures. Participants then completed an online personality survey at a later date. The results confirmed hypotheses that a high amount of pictures of oneself with close others will be associated with higher levels of social well-being, and a high amount of pictures involving the self only, strangers (celebrities and fantasy) and distant others (deceased, pet) will be associated with lower levels of social well-being. The study also showed important differences between men and women in the association between social well-being and the use of distant others and strangers as profile pictures

Spectral and total radiation properties of turbulent carbon monoxide/air diffusion flames

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76724/1/AIAA-1986-294-399.pd

Reconstructing 3D x-ray CT images of polymer gel dosimeters using the zero-scan method

In this study x-ray CT has been used to produce a 3D image of an irradiated PAGAT gel sample, with noise-reduction achieved using the ‘zero-scan’ method. The gel was repeatedly CT scanned and a linear fit to the varying Hounsfield unit of each pixel in the 3D volume was evaluated across the repeated scans, allowing a zero-scan extrapolation of the image to be obtained. To minimise heating of the CT scanner’s x-ray tube, this study used a large slice thickness (1 cm), to provide image slices across the irradiated region of the gel, and a relatively small number of CT scans (63), to extrapolate the zero-scan image. The resulting set of transverse images shows reduced noise compared to images from the initial CT scan of the gel, without being degraded by the additional radiation dose delivered to the gel during the repeated scanning. The full, 3D image of the gel has a low spatial resolution in the longitudinal direction, due to the selected scan parameters. Nonetheless, important features of the dose distribution are apparent in the 3D x-ray CT scan of the gel. The results of this study demonstrate that the zero-scan extrapolation method can be applied to the reconstruction of multiple x-ray CT slices, to provide useful 2D and 3D images of irradiated dosimetry gels

Direct esterification of poly (ethylene glycol) with amino acid hydrochlorides

Diesters of poly (ethylene glycol) with various a amino acid hydrochlorides were synthesized using dicyclohexyl carbodiimide as coupling agent. The use of hydrochloride as amino protecting group in dicyclohexyl carbodiimide mediated condensation reactions of amino acids was demonstrated for the first time

microRNA-10b enhances pancreatic cancer cell invasion by suppressing TIP30 expression and promoting EGF and TGF-β actions

Increased microRNA-10b (miR-10b) expression in the cancer cells in pancreatic ductal adenocarcinoma (PDAC) is a marker of disease aggressiveness. In the present study, we determined that plasma miR-10b levels are significantly increased in PDAC patients by comparison with normal controls. By gene profiling, we identified potential targets downregulated by miR-10b, including Tat-interacting protein 30 (TIP30). Immunoblotting and luciferase reporter assays confirmed that TIP30 was a direct miR-10b target. Downregulation of TIP30 by miR-10b or siRNA-mediated silencing of TIP30 enhanced epidermal growth factor (EGF)-dependent invasion. The actions of miR-10b were abrogated by expressing a modified TIP30 cDNA resistant to miR-10b. EGF-induced EGF receptor (EGFR) tyrosine phosphorylation and extracellular signal–regulated kinase phosphorylation were enhanced by miR-10b, and these effects were mimicked by TIP30 silencing. The actions of EGF in the presence of miR-10b were blocked by EGFR kinase inhibition with erlotinib and by dual inhibition of PI3K (phosphatidylinositol 3′-kinase) and MEK. Moreover, miR-10b, EGF and transforming growth factor-beta (TGF-β) combined to markedly increase cell invasion, and this effect was blocked by the combination of erlotinib and SB505124, a type I TGF-β receptor inhibitor. miR-10b also enhanced the stimulatory effects of EGF and TGF-β on cell migration and epithelial–mesenchymal transition (EMT) and decreased the expression of RAP2A, EPHB2, KLF4 and NF1. Moreover, miR-10b overexpression accelerated pancreatic cancer cell (PCC) proliferation and tumor growth in an orthotopic model. Thus, plasma miR-10b levels may serve as a diagnostic marker in PDAC, whereas intra-tumoral miR-10b promotes PCC proliferation and invasion by suppressing TIP30, which enhances EGFR signaling, facilitates EGF–TGF-β cross-talk and enhances the expression of EMT-promoting genes, whereas decreasing the expression of several metastasis-suppressing genes. Therefore, therapeutic targeting of miR-10b in PDAC may interrupt growth-promoting deleterious EGF–TGF-β interactions and antagonize the metastatic process at various levels

Salient Features Selection Techniques for Instruction Detection in Mobile Ad Hoc Networks

The development of wireless mobile ad hoc networks offers the promise of flexibility, low cost solution for the area where there is difficulties for infrastructure network. A key attraction of this mode of communication is their ease of deployment and operation. However, having a good and robust mobile ad hoc networking will depend entirely on security mechanism system in place. Traditional security mechanisms know as firewalls were used for defensive approach to oppose security obstacle. However, firewalls do not fully or completely defeat intrusions. To cope with this limitation, various intrusions detection systems (IDSs) have been proposed to detect such network intrusion activities. The problem encounter for this particular technique of instruction detections technique is that during network monitoring for data collection for anomaly detection, data that does not contribute to detection must be deleted before detection can be processed or application of learning algorithm for detection of abnormal attacks. In this paper we present a novel feature technique for feature selection before learning technique should be applied. The method has been applied into our own data set, and for the detection purpose we have used most of the well reputed three Machine Learning classifiers with the new selected features for performance evaluation and the experiment shows that higher accuracy results could be achieved with only all the 9 features extracted with our own algorithm with the data set created by using RandomForest classifier

Analysis of Limiters for ADITYA Tokamak

ADITYA Tokamak is a medium size ohmically heated tokamak. The hot plasma interacts with the vacuum vessel wall introducing impurities in the plasma and also damages the vacuum vessel wall. Limiter is used to reduce plasma - wall interaction and protect the vacuum vessel wall as well as inside components. It also controls impurity generation. ADITYA has a set of two types of limiters (i) Safety limiter (ii) a Poloidal limiter. Formally all the limiters are made of shaped graphite tiles fixed on stainless steel base plates. But graphite tiles are responsible for low Z impurities in plasma. To avoid these low Z impurities Molybdenum tiles are suggested. In this paper, we are going to present ansys analysis of surface temperature rise of molybdenum tiles compared to graphite tiles when used as Poloidal Limiter during plasma discharges in Aditya tokamak. The analysis is carried by ANSYS 11.0 software using Transient Thermal Analysis module. The results are compared with experimental results for graphite tiles. The graphite and molybdenum tiles are analyzed under same conditions

Assessing Change in a Personality Profile

We tested the validity of 6 methods (mean difference, variance difference, bivariate, profile agreement, pattern similarity, and intraclass) to assess change in a personality profile. During their first 2 months of college, 372 students completed reactive and spontaneous measures of their personality. Eight weeks later, 300 returned to complete a second set of the same measures and noted change in their spontaneous personality list. Sixty participants returned during their second semester to complete a third set of assessments. The bivariate and intraclass change coefficients showed consistent convergent, discriminant, and concurrent validity across time points. Recommendations and caveats for using these coefficients are discussed

Connection between Tutoring Format Type and Reading Scores of Elementary Aged Children

Extant research shows that response to intervention (RTI) individual and small group interventions increase children’s reading skills; however, little information is available that investigates whether the type of intervention format makes a difference in learning to read. The Early Childhood Longitudinal Study, Kindergarten class (ECLS-K) database was used to identify third-grade children who received individual, small group, or combined individual and small group tutoring, to increase their reading skills. The current study compared reading scores associated with each intervention type to determine which reading intervention format was most beneficial. The results from this study showed that children receiving small group intervention had higher reading scores than those receiving individual or combined interventions. In addition, a significant difference was found between the small group and combined formats. These results show the benefits of small group tutoring for elementary-aged children that could be beneficial in early prevention and identification of children who are struggling in reading