Reviews

Review of The Closed Shop, Industrial Relations in Australia, Toil and Trouble: The Struggle for a Better Life in New Zealan

An integrated circuit for chip-based analysis of enzyme kinetics and metabolite quantification

We have created a novel chip-based diagnostic tools based upon quantification of metabolites using enzymes specific for their chemical conversion. Using this device we show for the first time that a solid-state circuit can be used to measure enzyme kinetics and calculate the Michaelis-Menten constant. Substrate concentration dependency of enzyme reaction rates is central to this aim. Ion-sensitive field effect transistors (ISFET) are excellent transducers for biosensing applications that are reliant upon enzyme assays, especially since they can be fabricated using mainstream microelectronics technology to ensure low unit cost, mass-manufacture, scaling to make many sensors and straightforward miniaturisation for use in point-of-care devices. Here, we describe an integrated ISFET array comprising 216 sensors. The device was fabricated with a complementary metal oxide semiconductor (CMOS) process. Unlike traditional CMOS ISFET sensors that use the Si3N4 passivation of the foundry for ion detection, the device reported here was processed with a layer of Ta2O5 that increased the detection sensitivity to 45 mV/pH unit at the sensor readout. The drift was reduced to 0.8 mV/hour with a linear pH response between pH 2 – 12. A high-speed instrumentation system capable of acquiring nearly 500 fps was developed to stream out the data. The device was then used to measure glucose concentration through the activity of hexokinase in the range of 0.05 mM – 231 mM, encompassing glucose’s physiological range in blood. Localised and temporal enzyme kinetics of hexokinase was studied in detail. These results present a roadmap towards a viable personal metabolome machine

Towards a global analysis of polarized parton distributions

We present a technique for implementing in a fast way, and without any approximations, higher-order calculations of partonic cross sections into global analyses of parton distribution functions. The approach, which is set up in Mellin-moment space, is particularly suited for analyses of future data from polarized proton-proton collisions, but not limited to this case. The usefulness and practicability of this method is demonstrated for the semi-inclusive production of hadrons in deep-inelastic scattering and the transverse momentum distribution of ``prompt'' photons in pp collisions, and a case study for a future global analysis of polarized parton densities is presented.Comment: 20 pages, LaTeX, 6 eps figures, final version to appear in PRD (minor changes

A colorimetric CMOS-based platform for rapid total serum cholesterol quantification

Elevated cholesterol levels are associated with a greater risk of developing cardiovascular disease and other illnesses, making it a prime candidate for detection on a disposable biosensor for rapid point of care diagnostics. One of the methods to quantify cholesterol levels in human blood serum uses an optically mediated enzyme assay and a bench top spectrophotometer. The bulkiness and power hungry nature of the equipment limits its usage to laboratories. Here, we present a new disposable sensing platform that is based on a complementary metal oxide semiconductor process for total cholesterol quantification in pure blood serum. The platform that we implemented comprises readily mass-manufacturable components that exploit colorimetric changes of cholesterol oxidase and cholesterol esterase reactions. We have shown that our quantification results are comparable to that obtained by a bench top spectrophotometer. Using the implemented device, we have measured cholesterol concentration in human blood serum as low as 29 μM with a limit of detection at 13 μM, which is approximately 400 times lower than average physiological range, implying that our device also has the potential to be used for applications that require greater sensitivity

Magnetic ordering of Mn sublattice, dense Kondo lattice behavior of Ce in (RPd3)8Mn (R = La, Ce)

We have synthesized two new interstitial compounds (RPd3)8Mn (R = La and Ce). The Mn ions present in "dilute" concentration of just 3 molar percent form a sublattice with an unusually large Mn-Mn near neighbor distance of ~ 85 nm. While the existence of (RPd3)8M (where M is a p-block element) is already documented in the literature, the present work reports for the first time the formation of this phase with M being a 3d element. In (LaPd3)8Mn, the Mn sub-lattice orders antiferromagnetically as inferred from the peaks in low-field magnetization at 48 K and 23 K. The latter peak progressively shifts towards lower temperatures in increasing magnetic field and disappears below 1.8 K in a field of ~ 8 kOe. On the other hand in (CePd3)8Mn the Mn sublattice undergoes a ferromagnetic transition around 35 K. The Ce ions form a dense Kondo-lattice and are in a paramagnetic state at least down to 1.5 K. A strongly correlated electronic ground state arising from Kondo effect is inferred from the large extrapolated value of C/T = 275 mJ/Ce-mol K^2 at T = 0 K. In contrast, the interstitial alloys RPd3Mnx (x = 0.03 and 0.06), also synthesized for the first time, have a spin glass ground state due to the random distribution of the Mn ions over the available "1b" sites in the parent RPd3 crystal lattice.Comment: 18 figures and 20 pages of text documen

Simple choreographies of the planar Newtonian NN-body Problem

In the $N$-body problem, a simple choreography is a periodic solution, where all masses chase each other on a single loop. In this paper we prove that for the planar Newtonian $N$-body problem with equal masses, $N \ge 3$, there are at least $2^{N-3} + 2^{[(N-3)/2]}$ different main simple choreographies. This confirms a conjecture given by Chenciner and etc. in \cite{CGMS02}.Comment: 31pages, 6 figures. Refinements in notations and proof

Flow-duration curve integration into digital filtering algorithms for simulating climate variability based on river baseflow

A baseflow separation methodology combining the outcomes of the flow–duration curve and the digital filtering algorithms to cope with the restrictions of the traditional procedures has been assessed. Using this methodology as well as the monitored and simulated hydro-climatologic data, the baseflow annual variations due to climate change and human-induced activities were determined. The outcomes show that the long-term baseflow index at the upstream sub-basin is nearly half of that at the downstream from October to April, whereas, they are close to each other for the remaining months. Some of the groundwater reacts to precipitation and an evident rise in the groundwater contribution has been detected for the hydrological years 1998–2001 and 2006–2008. The contrary has been recorded for 1987. The water released from the reservoir in the dry periods lead to distinctions in the detected baseflow index between the pre-damming and post-damming periods of the river

Convex domains of Finsler and Riemannian manifolds

A detailed study of the notions of convexity for a hypersurface in a Finsler manifold is carried out. In particular, the infinitesimal and local notions of convexity are shown to be equivalent. Our approach differs from Bishop's one in his classical result (Bishop, Indiana Univ Math J 24:169-172, 1974) for the Riemannian case. Ours not only can be extended to the Finsler setting but it also reduces the typical requirements of differentiability for the metric and it yields consequences on the multiplicity of connecting geodesics in the convex domain defined by the hypersurface.Comment: 22 pages, AMSLaTex. Typos corrected, references update

Multiparton Interactions in Photoproduction at HERA

The high energy photoproduction of jets is being observed at the ep collider, HERA. It may be that the HERA centre-of-mass energy is sufficiently large that the production of more than one pair of jets per ep collision becomes possible, owing to the large number density of the probed gluons. We construct a Monte Carlo model of such multiparton interactions and study their effects on a wide range of physical observables. The conclusion is that multiple interactions could have very significant effects upon the photoproduction final state and that this would for example make extractions of the gluon density in the photon rather difficult. Total rates for the production of many (i.e. > 2) jets could provide direct evidence for the presence of multiple interactions, although parton showering and hadronization significantly affect low transverse energy jets.Comment: 21 pages, 8 figures include