3,748 research outputs found
SHELTER IN PLACE: Executive Order by the Governor to Ensure a Safe & Healthy Georgia
The Order required all visitors and residents of Georgia to practice social distancing in compliance with the Centers for Disease Control and Prevention guidelines; prohibited businesses in Georgia from allowing groups of more than ten people to gather at any single location; imposed a mandatory shelter-in-place requirement for all visitors and residents of Georgia except for essential workers, as defined within the Order; and laid out guidelines for how businesses would operate during the quarantine. Further, the Order limited restaurant services and closed certain businesses, including gyms and bowling alleys. The Order also superseded all local Orders purporting to regulate the same subject matter and declared violations of the Orderâs requirements to be a misdemeanor
Contribution of problem drug usersâ deaths to excess mortality in Scotland: secondary analysis of cohort study
Objectives To examine the âScottish effectâânamely, the growing divergence between mortality in Scotland and England that is not explained by national differences in levels of deprivationâand, more specifically, to examine the extent to which the Scottish effect is explained by cross national differences in the prevalence of problem drug use
Excitation spectrum and instability of a two-species Bose-Einstein condensate
We numerically calculate the density profile and excitation spectrum of a
two-species Bose-Einstein condensate for the parameters of recent experiments.
We find that the ground state density profile of this system becomes unstable
in certain parameter regimes, which leads to a phase transition to a new stable
state. This state displays spontaneously broken cylindrical symmetry. This
behavior is reflected in the excitation spectrum: as we approach the phase
transition point, the lowest excitation frequency goes to zero, indicating the
onset of instability in the density profile. Following the phase transition,
this frequency rises again.Comment: 8 pages, 5 figures, uses REVTe
Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion.
Estrogen receptor (ER)-negative cancers have a poor prognosis, and few targeted therapies are available for their treatment. Our previous analyses have identified potential kinase targets critical for the growth of ER-negative, progesterone receptor (PR)-negative and HER2-negative, or "triple-negative" breast cancer (TNBC). Because phosphatases regulate the function of kinase signaling pathways, in this study, we investigated whether phosphatases are also differentially expressed in ER-negative compared to those in ER-positive breast cancers. We compared RNA expression in 98 human breast cancers (56 ER-positive and 42 ER-negative) to identify phosphatases differentially expressed in ER-negative compared to those in ER-positive breast cancers. We then examined the effects of one selected phosphatase, dual specificity phosphatase 4 (DUSP4), on proliferation, cell growth, migration and invasion, and on signaling pathways using protein microarray analyses of 172 proteins, including phosphoproteins. We identified 48 phosphatase genes are significantly differentially expressed in ER-negative compared to those in ER-positive breast tumors. We discovered that 31 phosphatases were more highly expressed, while 11 were underexpressed specifically in ER-negative breast cancers. The DUSP4 gene is underexpressed in ER-negative breast cancer and is deleted in approximately 50 % of breast cancers. Induced DUSP4 expression suppresses both in vitro and in vivo growths of breast cancer cells. Our studies show that induced DUSP4 expression blocks the cell cycle at the G1/S checkpoint; inhibits ERK1/2, p38, JNK1, RB, and NFkB p65 phosphorylation; and inhibits invasiveness of TNBC cells. These results suggest that that DUSP4 is a critical regulator of the growth and invasion of triple-negative breast cancer cells
Draft genome sequence of isolate Staphylococcus aureus LHSKBClinical, isolated from an infected hip
We report here the genome sequence of a clinical isolate of <i>Staphylococcus aureus</i> from an orthopedic infection. Phenotypically diverse <i>Staphylococcus aureus</i> strains are associated with orthopedic infections and subsequent implant failure, and some are highly resistant to antibiotics. This genome sequence will support further analyses of strains causing orthopedic infections
The interaction of a gap with a free boundary in a two dimensional dimer system
Let be a fixed vertical lattice line of the unit triangular lattice in
the plane, and let \Cal H be the half plane to the left of . We
consider lozenge tilings of \Cal H that have a triangular gap of side-length
two and in which is a free boundary - i.e., tiles are allowed to
protrude out half-way across . We prove that the correlation function of
this gap near the free boundary has asymptotics ,
, where is the distance from the gap to the free boundary. This
parallels the electrostatic phenomenon by which the field of an electric charge
near a conductor can be obtained by the method of images.Comment: 34 pages, AmS-Te
Symmetric-Asymmetric transition in mixtures of Bose-Einstein condensates
We propose a new kind of quantum phase transition in phase separated mixtures
of Bose-Einstein condensates. In this transition, the distribution of the two
components changes from a symmetric to an asymmetric shape. We discuss the
nature of the phase transition, the role of interface tension and the phase
diagram. The symmetric to asymmetric transition is the simplest quantum phase
transition that one can imagine. Careful study of this problem should provide
us new insight into this burgeoning field of discovery.Comment: 6 pages, 3 eps figure
Strong coupling in molecular systems: a simple predictor employing routine optical measurements
We provide a simple method that enables readily acquired experimental data to
be used to predict whether or not a candidate molecular material may exhibit
strong coupling. Specifically, we explore the relationship between the hybrid
molecular/photonic (polaritonic) states and the bulk optical response of the
molecular material. For a given material this approach enables a prediction of
the maximum extent of strong coupling (vacuum Rabi splitting), irrespective of
the nature of the confined light field. We provide formulae for the upper limit
of the splitting in terms of the molar absorption coefficient, the attenuation
coefficient, the extinction coefficient (imaginary part of the refractive
index) and the absorbance. To illustrate this approach we provide a number of
examples, we also discuss some of the limitations of our approach
Nutritional B vitamin deficiency alters the expression of key proteins associated with vascular smooth muscle cell proliferation and migration in the aorta of atherosclerotic apolipoprotein E null mice.
Low B vitamin status is linked with human vascular disease. We employed a proteomic and biochemical approach to determine whether nutritional folate deficiency and/or hyperhomocysteinemia altered metabolic processes linked with atherosclerosis in ApoE null mice. Animals were fed either a control fat (C; 4 % w/w lard) or a high-fat [HF; 21 % w/w lard and cholesterol (0/15 % w/w)] diet with different B vitamin compositions for 16 weeks. Aorta tissue was prepared and global protein expression, B vitamin, homocysteine and lipoprotein status measured. Changes in the expression of aorta proteins were detected in response to multiple B vitamin deficiency combined with a high-fat diet (P < 0.05) and were strongly linked with lipoprotein concentrations measured directly in the aorta adventitia (P < 0.001). Pathway analysis revealed treatment effects in the aorta-related primarily to cytoskeletal organisation, smooth muscle cell adhesion and invasiveness (e.g., fibrinogen, moesin, transgelin, vimentin). Combined B vitamin deficiency induced striking quantitative changes in the expression of aorta proteins in atherosclerotic ApoE null mice. Deregulated expression of these proteins is associated with human atherosclerosis. Cellular pathways altered by B vitamin status included cytoskeletal organisation, cell differentiation and migration, oxidative stress and chronic inflammation. These findings provide new insight into the molecular mechanisms through which B vitamin deficiency may accelerate atherosclerosis
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