Drastically suppressing the error of ballistic readout of qubits

The thermal jitter of transmission of magnetic flux quanta in long Josephson junctions is studied. While for large-to-critical damping and small values of bias current the physically obvious dependence of the jitter versus length $\sigma\sim\sqrt{L}$ is confirmed, for small damping starting from the experimentally relevant $\alpha=0.03$ and below strong deviation from $\sigma\sim\sqrt{L}$ is observed, up to nearly complete independence of the jitter versus length, which is exciting from fundamental point of view, but also intriguing from the point of view of possible applications.Comment: 4 pages, 6 figure

ДИАГНОСТИКА И ЛЕЧЕНИЕ ТУБЕРКУЛЕЗА ОРГАНОВ ДЫХАНИЯ У БОЛЬНОГО ПОСЛЕ ТРАНСПЛАНТАЦИИ ПОЧКИ

Tuberculosis incidence among those, expecting kidney transplantation or after kidney transplantation is 10 times higher than the one in the general population, which is related to the development of drug-induced immune deficiency. So far there is no universal approach to treatment of such patients since numerous factors are to be taken into account: drug resistance of mycobacteria, the interaction of anti-tuberculosis drugs and immunosuppressive agents, development of adverse reactions and toxic effect on the kidney. The article presents a clinical case of diagnostics and successful treatment of pulmonary tuberculosis, tuberculosis of chest lymph nodes and bronchi in the patient with chronic renal failure in the terminal stage after the kidney transportation.Заболеваемость туберкулезом среди лиц, ожидающих трансплантацию почки или живущих с трансплантированной почкой, превышает таковую в общей популяции в десятки раз, что связано с формированием медикаментозного иммунодефицита. Пока не существует единого подхода к лечению туберкулеза у таких пациентов, так как следует учитывать многие факторы: лекарственную устойчивость возбудителя, взаимодействие противотуберкулезных и иммуносупрессивных препаратов, развитие нежелательных побочных реакций и токсическое воздействие на почку. Приводится клинический случай диагностики и успешного лечения туберкулеза легких, внутригрудных лимфатических узлов и бронхов у пациента с хронической болезнью почек в терминальной стадии после трансплантации почки

Role of apoptosis-inducing factor (AIF) in programmed nuclear death during conjugation in Tetrahymena thermophila

<p>Abstract</p> <p>Background</p> <p>Programmed nuclear death (PND), which is also referred to as nuclear apoptosis, is a remarkable process that occurs in ciliates during sexual reproduction (conjugation). In <it>Tetrahymena thermophila</it>, when the new macronucleus differentiates, the parental macronucleus is selectively eliminated from the cytoplasm of the progeny, concomitant with apoptotic nuclear events. However, the molecular mechanisms underlying these events are not well understood. The parental macronucleus is engulfed by a large autophagosome, which contains numerous mitochondria that have lost their membrane potential. In animals, mitochondrial depolarization precedes apoptotic cell death, which involves DNA fragmentation and subsequent nuclear degradation.</p> <p>Results</p> <p>We focused on the role of mitochondrial apoptosis-inducing factor (AIF) during PND in <it>Tetrahymena</it>. The disruption of <it>AIF </it>delays the normal progression of PND, specifically, nuclear condensation and kilobase-size DNA fragmentation. AIF is localized in <it>Tetrahymena </it>mitochondria and is released into the macronucleus prior to nuclear condensation. In addition, AIF associates and co-operates with the mitochondrial DNase to facilitate the degradation of kilobase-size DNA, which is followed by oligonucleosome-size DNA laddering.</p> <p>Conclusions</p> <p>Our results suggest that <it>Tetrahymena </it>AIF plays an important role in the degradation of DNA at an early stage of PND, which supports the notion that the mitochondrion-initiated apoptotic DNA degradation pathway is widely conserved among eukaryotes.</p

The Structural and Functional State of Soil Microbiota in a Chemically Polluted Environment

The structural and functional diversity of the main ecological trophic groups of soil microorganisms in meadow soils of the Central Urals anthropogenically contaminated with heavy metals was studied. The increase in the total numbers of these microorganisms in technozems, in comparison with those in agrozems, is due to the higher abundance of iron-reducing, denitrifying, nitrogen-fixing, and sulfate-reducing bacteria, an increase in cellulolytic activity, and the dependence of these characteristics on the toxic load of the soil. A reductive structure of the microbial community with the predominance of r-strategists, which reflects earlier stages of microbiocenoses succession under soil contamination, is formed under soil pollution with heavy metals. © 2017, Pleiades Publishing, Inc.Ural Branch, Russian Academy of Sciences: 12-I-4-2051ACKNOWLEDGMENTS This work was supported by the Government of Sverdlovsk oblast, the Russian Foundation for Basic Research (project no. 13-04-96056-r_ural_a), and a Program of the Presidium of the Ural Branch, Russian Academy of Sciences (project no. 12-I-4-2051)

DIAGNOSTICS AND TREATMENT OF RESPIRATORY TUBERCULOSIS IN THE PATIENT AFTER KIDNEY TRANSPORTATION

Tuberculosis incidence among those, expecting kidney transplantation or after kidney transplantation is 10 times higher than the one in the general population, which is related to the development of drug-induced immune deficiency. So far there is no universal approach to treatment of such patients since numerous factors are to be taken into account: drug resistance of mycobacteria, the interaction of anti-tuberculosis drugs and immunosuppressive agents, development of adverse reactions and toxic effect on the kidney. The article presents a clinical case of diagnostics and successful treatment of pulmonary tuberculosis, tuberculosis of chest lymph nodes and bronchi in the patient with chronic renal failure in the terminal stage after the kidney transportation