<span style="font-size:11.0pt;mso-bidi-font-size: 10.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-GB;mso-fareast-language:EN-US;mso-bidi-language:AR-SA" lang="EN-GB">Chemical composition and antimicrobial activity of <i style="mso-bidi-font-style:normal">Syzygium caryophyllatum </i>(L.) Alston leaf oil</span>

747-751<span style="font-size:11.0pt;mso-bidi-font-size: 9.0pt;font-family:" times="" new="" roman","serif";mso-fareast-font-family:"times="" roman";="" letter-spacing:-.1pt;mso-ansi-language:en-gb;mso-fareast-language:en-us;="" mso-bidi-language:ar-sa"="" lang="EN-GB">Chemical composition of the essential oil obtained from the leaves of Syzygium caryophyllatum has been analyzed by GC and GC-MS Twenty four compounds representing 89.7% of the oil have been identified. Major components are δ-cadinol (42.1%), caryophyllene (13.4%) and selin-11-en-4-α-ol (5.4%). Antimicrobial activity of the leaf oil has been carried out by disc diffusion method in vitro antimicrobial assay. As compared to standard fluconazole, a 1:2 dilution of the leaf oil shows strong inhibition against strains of Candida albicans. The Syzygium leaf oil exhibits a pronounced activity against Candida albicans with a minimal-inhibitory concentration (MIC) of 44.0 µg/mL.</span

Ameliorative effect of alkaloid extract of Cyclea peltata (Poir.) Hook. f. & Thoms. roots (ACP) on APAP/CCl4 induced liver toxicity in Wistar rats and in vitro free radical scavenging property

Objective: To evaluate the hepatoprotective and antioxidant properties of alkaloid extract of Cyclea peltata (C. peltata) against paracetamol/carbon tetra chloride induced liver damage in Wistar rats. Methods: In vivo paracetamol/carbon tetrachloride induced liver damage in Wistar rats, in vitro free radical scavenging studies, HPTLC estimation of tetrandrine and direct analysis in real time-mass spectrometry of alkaloid extract of C. peltata were used for the validation. Results: The results showed that pretreatment with alkaloid extract of C. peltata caused significant reduction of serum glutamate pyruvate transaminase, serum glutamate oxaloacetate transaminase, serum alkaline phosphatase, serum cholesterol, liver malondialdehyde levels. The reduced glutathione, catalase, superoxide dismutase levels in liver were increased with alkaloid extract of C. peltata treatment. These results were almost comparable to silymarin and normal control. Histopathological studies also substantiated the biochemical findings. The in vitro hydroxyl, superoxide and DPPH scavenging study of alkaloid extract of C. peltata showed significant free radical scavenging property. Conclusions: The hepatoprotective property of alkaloid extract of C. peltata against paracetamol/carbon tetrachloride may be due the synergistic action of alkaloids especially tetrandrine, fangchinoline through free radical scavenging and thus preventing oxidative stress