Island constraints are not the result of sentence processing

On the basis of a comparison between sentence judgements in English vs. Akan, we argue that island constraints (positions to which a question word can be linked) cannot be reduced to the effects of the sentence processing mechanism.  Questions that violate constraints are judged better in Akan than in English, although the challenge to the sentence processor is the same for the two languages. We argue specifically that the constraints cannot be reduced to the effects of specificity of the question phrase, and must be attributed to two different grammatical mechanisms for the languages

LRRK1 regulation of actin assembly in osteoclasts involves serine 5 phosphorylation of L-plastin

Mice with disruption of Lrrk1 and patients with nonfunctional mutant Lrrk1 exhibit severe osteopetrosis phenotypes because of osteoclast cytoskeletal dysfunction. To understand how Lrrk1 regulates osteoclast function by modulating cytoskeleton rearrangement, we examined the proteins that are differentially phosphorylated in wild-type mice and Lrrk1-deficient osteoclasts by metal affinity purification coupled liquid chromatography/mass spectrometry (LC/MS) analyses. One of the candidates that we identified by LC/MS is L-plastin, an actin bundling protein. We found that phosphorylation of L-plastin at serine (Ser) residues 5 was present in wild-type osteoclasts but not in Lrrk1-deficient cells. Western blot analyses with antibodies specific for Ser5 phosphorylated L-plastin confirmed the reduced L-plastin Ser5 phosphorylation in Lrrk1 knockout (KO) osteoclasts. micro computed tomography (Micro-CT) analyses revealed that the trabecular bone volume of the distal femur was increased by 27% in the 16 to 21-week-old L-plastin KO females as compared with the wild-type control mice. The ratio of bone volume to tissue volume and connectivity density were increased by 44% and 47% (both P \u3c 0.05), respectively, in L-plastin KO mice. Our data suggest that targeted disruption of L-plastin increases trabecular bone volume, and phosphorylation of Ser5 in L-plastin in the Lrrk1 signaling pathway may in part contribute to actin assembly in mature osteoclasts

Discourse effects on older children’s interpretations of complement control and temporal adjunct control

The reference of understood subjects (ecs) in complement control (John persuaded Peteri eci to read the book) and temporal adjunct control (Johni tapped Peter while eci reading the book) has long been described as restricted to the object and subject of the main clause respectively. These restrictions have shaped the grammatical targets proposed for children, most of whom are reported as having acquired both sub-types by seven. Using three picture-selection tasks, 76 children’s (34 girls; aged 6;9-11;8) interpretations of the ecs were tested. Task 1 established their base-line preferences. Task 2 weakly cued the ecs towards an alternative referent and Task 3 strongly towards an alternative referent. Complement control responses were consistent across all tasks but in adjunct control they shifted significantly towards the object in Task 3 – a pattern mirrored by 15 adults. Responses in adjunct control also exhibited a degree of fluctuation in the baseline condition that complement control did not. A follow-up study on adjunct control showed that neither children nor adults permitted an external-referent reading, even when strongly cued in that direction. Two alternative proposals are discussed: one in which the results are viewed solely as the product of a parser’s sensitivity to activation and another that proposes two possible structures for adjunct control; this permits the evident interpretation shift yet gives precedence to the highly preferred subject-oriented reading