Disorder, Dissatisfaction with the Neighborhood, and Delinquency

This study examines the association between neighborhood dissatisfaction and adolescent delinquency. The objectives of this project are to determine (1) whether neighborhood disorder is related to delinquency among adolescents (2) whether adolescents who report increased levels of neighborhood dissatisfaction are relatively more involved in delinquency than their peers, (3) if neighborhood dissatisfaction is especially related to two types of delinquency implicated by strain theory, violence and substance abuse, and (4) if neighborhood dissatisfaction weakens any of the association between neighborhood disorder and crime. Applying stepwise logistical regression, I find little support for the association between disorder and adolescent offending and no association between neighborhood dissatisfaction with either violence or substance abuse when compared to the likelihood of engaging in instrumental crime. These findings raise questions regarding the relationship between disorder and individual levels of delinquency as well as the relationship between disorder and neighborhood dissatisfaction among adolescents

Briefing:Concrete – Innovations and practical applications

Concrete is a highly adaptable material and capable of considerable variation, development and innovation, as can be seen from the pages of journals such as the Proceedings of the Institution of Civil Engineers–Construction Materials. This briefing paper describes the 43rd Convention of the Institute of Concrete Technology, which took place on 26 March 2015. The event provided an opportunity for practitioners and researchers to meet and communicate, and to showcase the variety and diversity of current innovations, developments and applications in concrete and cement technology, including carbon-negative aggregate, polycarboxylate ether superplasticisers, waste wood in concrete, steel fibres, calcium aluminate cements, superabsorbent polymers and sprayed concrete tunnel linings

The importance of infiltration pathways in assessing and modelling overheating risks in multi-residential buildings

With the help of building diagnostics, the causes and solutions to complex problems in buildings can be determined. In central and greater London, an increasing number of cases of chronic, year-round, overheating in buildings have been reported. We present three cases of unexpected temperatures in multi-storey residential buildings. Detailed analysis and modelling of these scenarios have led to an investigation of whether the way in which infiltration is currently modelled in building performance simulation may be exerting a pronounced effect on the results of overheating studies. An EnergyPlus model, of one of the dwellings in a multi-residential building in London, was created to investigate the influence of infiltration and exfiltration pathway assumptions on the prediction of overheating. The simulation results were compared to empirical data and show that the predicted indoor temperatures are highly sensitive to how the infiltration airflow network is modelled. The findings of this study have been used to provide practical guidance for modellers and building designers on critical aspects to consider when creating building performance simulation models to ensure more reliable outcomes

Achieving a better understanding of air infiltration when assessing overheating in multi-residential dwellings

In temperate climates the prediction of indoor temperatures using Building Performance Simulation (BPS) is thought to be highly sensitive to assumptions regarding convective and radiative heat transfer processes. This paper investigates whether the way in which infiltration is modelled may be exerting a pronounced effect on the results of overheating studies. An EnergyPlus model, of a dwelling in a multiresidential building in London, was created to investigate the influence of infiltration and exfiltration pathway assumptions on the prediction of overheating. Baseline modelling in accordance with the CIBSE TM59 methodology was compared to scenarios using best practice dynamic modelling procedures. The findings were compared to empirical data and show that the indoor temperatures are highly sensitive to how the infiltration airflow network is modelled. The results of this study provide practical guidance for modellers and building designers on what aspects to consider when creating energy models to ensure more reliable outcomes. Implementation of these findings is considered crucial for the further development of TM59 where reliable results are central to informing robust designs and preventing unnecessary overheating risks in future low energy building design

Short Interspersed Element (SINE) Depletion and Long Interspersed Element (LINE) Abundance Are Not Features Universally Required for Imprinting

Genomic imprinting is a form of gene dosage regulation in which a gene is expressed from only one of the alleles, in a manner dependent on the parent of origin. The mechanisms governing imprinted gene expression have been investigated in detail and have greatly contributed to our understanding of genome regulation in general. Both DNA sequence features, such as CpG islands, and epigenetic features, such as DNA methylation and non-coding RNAs, play important roles in achieving imprinted expression. However, the relative importance of these factors varies depending on the locus in question. Defining the minimal features that are absolutely required for imprinting would help us to understand how imprinting has evolved mechanistically. Imprinted retrogenes are a subset of imprinted loci that are relatively simple in their genomic organisation, being distinct from large imprinting clusters, and have the potential to be used as tools to address this question. Here, we compare the repeat element content of imprinted retrogene loci with non-imprinted controls that have a similar locus organisation. We observe no significant differences that are conserved between mouse and human, suggesting that the paucity of SINEs and relative abundance of LINEs at imprinted loci reported by others is not a sequence feature universally required for imprinting

Evolution records a Mx tape for anti-viral immunity

Viruses impose diverse and dynamic challenges on host defenses. Diversifying selection of codons and gene copy number variation are two hallmarks of genetic innovation in antiviral genes engaged in host-virus genetic conflicts. The myxovirus resistance (Mx) genes encode interferon-inducible GTPases that constitute a major arm of the cell-autonomous defense against viral infection. Unlike the broad antiviral activity of MxA, primate MxB was recently shown to specifically inhibit lentiviruses including HIV-1. We carried out detailed evolutionary analyses to investigate whether genetic conflict with lentiviruses has shaped MxB evolution in primates. We found strong evidence for diversifying selection in the MxB N-terminal tail, which contains molecular determinants of MxB anti-lentivirus specificity. However, we found no overlap between previously-mapped residues that dictate lentiviral restriction and those that have evolved under diversifying selection. Instead, our findings are consistent with MxB having a long-standing and important role in the interferon response to viral infection against a broader range of pathogens than is currently appreciated. Despite its critical role in host innate immunity, we also uncovered multiple functional losses of MxB during mammalian evolution, either by pseudogenization or by gene conversion from MxA genes. Thus, although the majority of mammalian genomes encode two Mx genes, this apparent stasis masks the dramatic effects that recombination and diversifying selection have played in shaping the evolutionary history of Mx genes. Discrepancies between our study and previous publications highlight the need to account for recombination in analyses of positive selection, as well as the importance of using sequence datasets with appropriate depth of divergence. Our study also illustrates that evolutionary analyses of antiviral gene families are critical towards understanding molecular principles that govern host-virus interactions and species-specific susceptibility to viral infection

Assessment of interventions to reduce dwelling overheating during heat waves considering annual energy use and cost.

Climate change projections indicate that the UK is expected to experience more frequent and more intense heat wave periods over the coming decades. Buildings frequently experience overheating even under the present climate, resulting in discomfort, health complaints and even mortality. Current house building rates are low, resulting in a need to adapt the existing building stock to provide more comfortable and safe environments. Dynamic thermal simulation computer modelling was used to assess and rank the effectiveness of selected single and combined interventions (adaptations) in reducing overheating during a heat wave period for a range of dwelling types, orientations and occupancy profiles. It is shown that solar protection interventions, such as window shutters and solar reflective coatings, can be amongst the most effective at reducing overheating during heat wave periods, but with a corresponding increase in annual space heating energy use. Whereas the addition of wall insulation, though beneficial for reducing energy use, may in some cases actually increase summer overheating. The results and guidance are presented in a way that allows identification of parts of the building stock most at risk and rapid selection of the best performing interventions in terms of overheating reduction, cost and annual energy use. It is also shown that above certain cost levels there is a diminishing return in both overheating performance and energy use reduction. The results of this research will provide important information to support refurbishment decisions of both individual house owners and landlords responsible for multiple properties, such as housing associations and local authorities