The impact of childhood language difficulties on healthcare costs from 4 to 13 years: Australian longitudinal study

© 2016 The Speech Pathology Association of Australia Limited Published by Taylor & Francis. Purpose: This study investigated the relationship between children’s language difficulties and health care costs using the 2004–2012 Longitudinal Study of Australian Children (LSAC). Method: Language difficulties were defined as scores ≤1.25SD below the standardised mean on measures of directly assessed receptive vocabulary (4–9 years) and teacher-reported language and literacy (10–13 years). Participant data were individually linked to administrative data, which were sourced from Australia’s universal subsidised healthcare scheme (Medicare). Result: It was found that healthcare costs over each 2-year age band were higher for children with language difficulties than without in the 4–5-year-age bracket (mean difference = AU$357, 95$59, $659), in the 6–7-year-age bracket (mean difference = AU$602, 95%CI $136,$1068) and in the 10–11-year-age bracket (mean difference = AU$504, 95$153, $854). Out-of-pocket costs, that is the portion of healthcare costs paid for by the family, were also higher for children with than without language difficulties in the 4–5-year-age bracket (mean difference = AU$123, 95%CI $46,$199), in the 6–7-year-age bracket (mean difference = AU$176, 95$74,278) and in the 10–11-year-age bracket (mean difference = AU$79, 95$6, $152). Medical services accounted for 97% of total healthcare cost differences. Conclusion: Overall the findings from this study suggest that language difficulties are associated with increased healthcare costs at key developmental milestones, notably early childhood and as a child approaches the teenage years

Neurophysiology

Contains reports on eight research projects.Bell Telephone Laboratories, Inc.Teagle Foundation, Inc.National Science Foundation (Grant GP-2495)National Institutes of Health (Grants MH-04737-04)National Institutes of Health (NB-04985-01)U. S. Air Force. Aeronautical Systems Division (Contract AF 33(615)-1747)U. S. Air Force. Cambridge Research Laboratories (Contract AF19(628)-3807)U. S. Air Force. Electronic Systems Division (Contract AF19(628)-4147)National Aeronautics and Space Administration (Grant NsG-496

Thermodynamic Signature of a Two-Dimensional Metal-Insulator Transition

We present a study of the compressibility, K, of a two-dimensional hole system which exhibits a metal-insulator phase transition at zero magnetic field. It has been observed that dK/dp changes sign at the critical density for the metal-insulator transition. Measurements also indicate that the insulating phase is incompressible for all values of B. Finally, we show how the phase transition evolves as the magnetic field is varied and construct a phase diagram in the density-magnetic field plane for this system.Comment: 4 pages, 4 figures, submitted to Physical Review Letters; version 1 is identical to version 2 but didn't compile properl

Determination of iodine and molybdenum in milk by quadrupole ICP-MS

A reliable method for the determination of iodine and molybdenum in milk samples, using alkaline digestion with tetramethylammonium hydroxide and hydrogen peroxide, followed by quadrupole ICP-MS analysis, has been developed and tested using certified reference materials. The use of He + O2 (1.0 ml min-1 and 0.6 ml min-1) in the collision-reaction cell of the mass spectrometer to remove 129Xe+ - initially to enable the determination of low levels of 129I - also resulted in the quantitative conversion of Mo+ to MoO2+ which enabled the molybdenum in the milk to be determined at similar mass to the iodine with the use of Sb as a common internal standard. In order to separate and pre-concentrate iodine at sub μg L-1 concentrations, a novel method was developed using a cation-exchange column loaded with Pd2+ and Ca2+ ions to selectively retain iodide followed by elution with a small volume of ammonium thiosulfate. This method showed excellent results for aqueous iodide solutions, although the complex milk digest matrix made the method unsuitable for such samples. An investigation of the iodine species formed during oxidation and extraction of milk sample digests was carried out with a view to controlling the iodine chemistry

A new approach to estimate fecundity rate from inter-birth intervals

Funded by Department of Energy and Climate Change (UK), BES, ASAB, Greenpeace, Environmental Trust, Scottish Natural Heritage, Scottish Government, Whale and Dolphin Conservation, Talisman Energy (UK) Ltd., DECC, Chevron, Natural Environment Research Council Acknowledgments Funding for this work was provided by the Department of Energy and Climate Change (UK). Photo-identification data were collected during a series of grants and contracts from the BES, ASAB, Greenpeace Environmental Trust, Scottish Natural Heritage, Scottish Government, Whale and Dolphin Conservation, Talisman Energy (UK) Ltd., DECC, Chevron, and the Natural Environment Research Council. All survey work was carried out under Scottish Natural Heritage Animal Scientific Licences. The authors have no conflict of interest to declare. We thank Mark Bravington for his helpful advice at the early stages of this work and two anonymous reviewers for their useful comments on the manuscript.Peer reviewedPublisher PD

Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers

Mice rendered deficient in CD28 signaling by the soluble competitor, cytotoxic T lymphocyte-associated molecule 4-immunoglobulin G1 fusion protein (CTLA4-Ig), fail to upregulate OX40 expression in vivo or form germinal centers after immunization. This is associated with impaired interleukin 4 production and a lack of CXC chemokine receptor (CXCR)5 on CD4 T cells, a chemokine receptor linked with migration into B follicles. Germinal center formation is restored in CTLA4-Ig transgenic mice by coinjection of an agonistic monoclonal antibody to CD28, but this is substantially inhibited if OX40 interactions are interrupted by simultaneous injection of an OX40-Ig fusion protein. These data suggest that CD28-dependent OX40 ligation of CD4 T cells at the time of priming is linked with upregulation of CXCR5 expression, and migration of T cells into B cell areas to support germinal center formation