6,196 research outputs found
Sensitivity of a climatologically-driven sea ice model to the ocean heat flux
Ocean heat flux sensitivity was studied on a numerical model of sea ice covering the Weddell Sea region of the southern ocean. The model is driven by mean monthly climatological atmospheric variables. For each model run, the ocean heat flux is uniform in both space and time. Ocean heat fluxes below 20 W m to the minus 2 power do not provide sufficient energy to allow the ice to melt to its summertime thicknesses and concentrations by the end of the 14 month simulation, whereas ocean heat fluxes of 30 W m to the minus 2 power and above result in too much ice melt, producing the almost total disappearance of ice in the Weddell Sea by the end of the 14 months. These results are dependent on the atmospheric forcing fields
Polyhexamethylene Biguanide and Nadifloxacin Self-Assembled Nanoparticles: Antimicrobial Effects against Intracellular Methicillin-Resistant Staphylococcus aureus
The treatment of skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus (MRSA) remains a challenge, partly due to localization of the bacteria inside the hostâs cells, where antimicrobial penetration and efficacy is limited. We formulated the cationic polymer polyhexamethylene biguanide (PHMB) with the topical antibiotic nadifloxacin and tested the activities against intracellular MRSA in infected keratinocytes. The PHMB/nadifloxacin nanoparticles displayed a size of 291.3 ± 89.6 nm, polydispersity index of 0.35 ± 0.04, zeta potential of +20.2 ± 4.8 mV, and drug encapsulation efficiency of 58.25 ± 3.4%. The nanoparticles killed intracellular MRSA, and relative to free polymer or drugs used separately or together, the nanoparticles displayed reduced toxicity and improved host cell recovery. Together, these findings show that PHMB/nadifloxacin nanoparticles are effective against intracellular bacteria and could be further developed for the treatment of skin and soft tissue infections
Style and Performance of Agricultural Market Advisory Services
This paper describes the degree of marketing activeness of market advisory programs for corn and soybeans, and analyzes the relationship between activeness degree and pricing performance. The data set employed consists of advisory programs tracked by the AgMAS Project at the University of Illinois between 1995 and 2001. Cluster analysis was conducted to group the programs according to their degree of activeness. Panel data regression models were estimated to evaluate the relationship between activeness degree and pricing performance. In the corn market, point estimates indicate a positive effect of the degree of activeness on pricing performance, but this effect is of small magnitude and statistically insignificant. For soybeans,there is a stronger positive relationship between activeness degree and performance, with an estimated effect of activeness on performance larger in magnitude and statistically significant. This positive relationship suggests that active marketing programs are based on superior information and/or analytical skills.Agribusiness, Marketing,
Isospin asymmetry and type-I superconductivity in neutron star matter
It has been argued by Buckley et. al.(Phys. Rev. Lett. 92, 151102, 2004) that
nuclear matter is a type-I rather than a type-II superconductor. The suggested
mechanism is a strong interaction between neutron and proton Cooper pairs,
which arises from an assumed U(2) symmetry of the effective potential, which is
supposed to originate in isospin symmetry of the underlying nuclear
interactions. To test this claim, we perform an explicit mean-field calculation
of the effective potential of the Cooper pairs in a model with a simple
four-point pairing interaction. In the neutron star context, matter is very
neutron rich with less than 10% protons, so there is no neutron-proton pairing.
We find that under these conditions our model shows no interaction between
proton Cooper pairs and neutron Cooper pairs at the mean-field level. We
estimate the leading contribution beyond mean field and find that it is is
small and attractive at weak coupling.Comment: 7 pages, 2 figure
The Cure: Making a game of gene selection for breast cancer survival prediction
Motivation: Molecular signatures for predicting breast cancer prognosis could
greatly improve care through personalization of treatment. Computational
analyses of genome-wide expression datasets have identified such signatures,
but these signatures leave much to be desired in terms of accuracy,
reproducibility and biological interpretability. Methods that take advantage of
structured prior knowledge (e.g. protein interaction networks) show promise in
helping to define better signatures but most knowledge remains unstructured.
Crowdsourcing via scientific discovery games is an emerging methodology that
has the potential to tap into human intelligence at scales and in modes
previously unheard of. Here, we developed and evaluated a game called The Cure
on the task of gene selection for breast cancer survival prediction. Our
central hypothesis was that knowledge linking expression patterns of specific
genes to breast cancer outcomes could be captured from game players. We
envisioned capturing knowledge both from the players prior experience and from
their ability to interpret text related to candidate genes presented to them in
the context of the game.
Results: Between its launch in Sept. 2012 and Sept. 2013, The Cure attracted
more than 1,000 registered players who collectively played nearly 10,000 games.
Gene sets assembled through aggregation of the collected data clearly
demonstrated the accumulation of relevant expert knowledge. In terms of
predictive accuracy, these gene sets provided comparable performance to gene
sets generated using other methods including those used in commercial tests.
The Cure is available at http://genegames.org/cure
Interpretation, translation and intercultural communication in refugee status determination procedures in the UK and France
This article explores the interplay between language and intercultural communication within refugee status determination procedures in the UK and France, using material taken from ethnographic research that involved a combination of participant observation, semi-structured interviews and documentary analysis in both countries over a two-year period (2007â2009). It is concerned, in particular, to examine the role played by interpreters in facilitating intercultural communication between asylum applicants and the different administrative and legal actors responsible for assessing or defending their claims. The first section provides an overview of refugee status determination procedures in the UK and France, introducing the main administrative and legal contexts of the asylum process within which interpreters operate in the two countries. The second section compares the organisation of interpreting services, codes of conduct for interpreters and institutional expectations about the nature of interpretersâ activity on the part of the relevant UK and French authorities. The third section then explores some of the practical dilemmas for interpreters and barriers to communication that exist in refugee status determination procedures in the two countries. The article concludes by emphasising the complex and active nature of the interpreter's role in UK and French refugee status determination procedures
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