Heterogeneous Pd catalysts as emulsifiers in Pickering emulsions for integrated multistep synthesis in flow chemistry

Within the “Compartmentalised Smart Factory” approach of the ONE-FLOW project the implementation of different catalysts in “compartments” provided by Pickering emulsions and their application in continuous flow is targeted. We present here the development of heterogeneous Pd-catalysts that are ready to be used in combination with biocatalysts for catalytic cascade syntheses of active pharmaceutical ingredients (APIs). In particular, we focus on the application of the catalytic systems for Suzuki-Miyaura cross coupling reactions, which is the key step in the syntheses of the targeted APIs valsartan and sacubitril. An immobilised enzyme will accomplish the final product formation via hydrolysis. In order to create large interfacial area for the catalytic reactions and to keep the reagents separated until required, the catalyst particles are used to stabilise Pickering emulsions of oil and water. A set of Ce-Sn-Pd-oxides with the molecular formula Ce0.99-xSnxPd0.01O2-(x= 0-0.99) has been prepared utilising a simple single-step solution combustion method. The high applicability of the catalysts for different functional groups and their minimal leaching behaviour is demonstrated with various Suzuki-Miyaura cross coupling reactions in batch as well as in continuous flow employing the so-called “Plug & Play reactor”. Finally, we demonstrate the use of these particles as the sole emulsifier of oil + water emulsions for a range of oils

Exact Histogram Specification Optimized for Structural Similarity

An exact histogram specification (EHS) method modifies its input image to have a specified histogram. Applications of EHS include image (contrast) enhancement (e.g., by histogram equalization) and histogram watermarking. Performing EHS on an image, however, reduces its visual quality. Starting from the output of a generic EHS method, we maximize the structural similarity index (SSIM) between the original image (before EHS) and the result of EHS iteratively. Essential in this process is the computationally simple and accurate formula we derive for SSIM gradient. As it is based on gradient ascent, the proposed EHS always converges. Experimental results confirm that while obtaining the histogram exactly as specified, the proposed method invariably outperforms the existing methods in terms of visual quality of the result. The computational complexity of the proposed method is shown to be of the same order as that of the existing methods. Index terms: histogram modification, histogram equalization, optimization for perceptual visual quality, structural similarity gradient ascent, histogram watermarking, contrast enhancement

A Rigourous Treatment of the Lattice Renormalization Problem of F_B

The $B$-meson decay constant can be measured on the lattice using a $1/m_b$ expansion. To relate the physical quantity to Monte Carlo data one has to know the renormalization coefficient, $Z$, between the lattice operators and their continuum counterparts. We come back to this computation to resolve discrepancies found in previous calculations. We define and discuss in detail the renormalization procedure that allows the (perturbative) computation of $Z$. Comparing the one-loop calculations in the effective Lagrangian approach with the direct two-loop calculation of the two-point $B$-meson correlator in the limit of large $b$-quark mass, we prove that the two schemes give consistent results to order $\alpha_s$. We show that there is, however, a renormalization prescription ambiguity that can have sizeable numerical consequences. This ambiguity can be resolved in the framework of an $O(a)$ improved calculation, and we describe the correct prescription in that case. Finally we give the numerical values of $Z$ that correspond to the different types of lattice approximations discussed in the paper.Comment: 27 pages, 2 figures (Plain TeX, figures in an appended postscript file

Magnetic and superconducting instabilities of the Hubbard model at the van Hove filling

We use a novel temperature-flow renormalization group technique to analyze magnetic and superconducting instabilities in the two-dimensional t-t' Hubbard model for particle densities close to the van Hove filling as a function of the next-nearest neighbor hopping t'. In the one-loop flow at the van Hove filling, the characteristic temperature for the flow to strong coupling is suppressed drastically around t'_c approx. -0.33t, suggesting a quantum critical point between d-wave pairing at moderate t'>t'_c and ferromagnetism for t'<t'_c. Upon increasing the particle density in the latter regime the leading instability occurs in the triplet pairing channel.Comment: 4 pages, to appear in Physical Review Letter

Chaplygin gas with non-adiabatic pressure perturbations

Perturbations in a Chaplygin gas, characterized by an equation of state $p = -A/\rho$, may acquire non-adiabatic contributions if spatial variations of the parameter $A$ are admitted. This feature is shown to be related to a specific internal structure of the Chaplygin gas. We investigate how perturbations of this type modify the adiabatic sound speed and influence the time dependence of the gravitational potential which gives rise to the Integrated Sachs-Wolfe effect in the anisotropy spectrum of the cosmic microwave background.Comment: 16 pages, comments and references added, accepted for publication in Class.Quantum Gra