L’exercici físic durant l’embaràs: un risc per al nounat?

Presentem un treball d’investigació que relaciona l’exercici físic realitzat durant el segon i el tercer trimestre d’embaràs amb la salut general del nounat. Es va dur a terme un treball experimental, del tipus de Casos i Controls, que va incloure un total de 142 dones gestants, després d’entrevistar 480 dones embarassades en la seva primera consulta prenatal. El treball va consistir en 3 classes setmanals de 35 minuts cada una d’exercici aeròbic de caràcter moderat, desenvolupat durant el segon i el tercer trimestre d’embaràs. Totes les gestants van ser consultades per factors que poguessin actuar “de confusió” (edat, paritat, activitat laboral, tabaquisme). Es van valorar un seguit de paràmetres maternofetals, especialment el pes i la talla de naixement, Test d’APGAR i tipus de part, igual com l’edat gestacional materna en el moment del part. Els resultats obtinguts permeten de concloure que la pràctica d’exercici moderat durant el segon i el tercer trimestre d’embaràs no ocasionen riscs en l’estat de salut general del nounat

El ejercicio físico durante el embarazo: ¿un riesgo para el recién nacido?

Presentamos aquí un trabajo de investigación que relaciona el ejercicio físico realizado durante el segundo y tercer trimestre de embarazo con la salud general de recién nacido. Se llevó a cabo un trabajo experimental, del tipo de Casos y Controles, que incluyó un total de 142 mujeres gestantes, luego de entrevistar a 480 mujeres embarazadas en su primera consulta prenatal. El trabajo consistió en 3 clases semanales de 35 minutos cada una de ejercicio aeróbico de carácter moderado desarrollado durante el segundo y tercer trimestre de embarazo. Todas las gestantes fueron consultadas por factores que pudiesen actuar como “de confusión” (edad, paridad, actividad laboral, tabaquismo). Se valoraron una serie de parámetros materno-fetales, especialmente el peso y talla de nacimiento, Test de APGAR y tipo de parto, así como edad gestacional materna en el momento del parto. Los resultados obtenidos permiten concluir que la práctica de ejercicio moderado durante el segundo y tercer trimestre de embarazo no ocasionan riesgos en el estado de salud general del recién nacido

Updating the statistics reported for the EU-Spain purse seine fishing fleet in the Indian Ocean (period 1984-2019) and the effects of the COVID-19 pandemic on the port sampling activity in Victoria (Seychelles)

This document provides an update on the statistics reported for the Spanish purse seine fleet fisheries in the Indian Ocean for the period 1984 to 2019. Data include catch and effort statistics, as well as some fishery indicators by species and fishing mode. Information about the coverage of the sampling, together with maps and diagrams illustrating the spatial-temporal fishing patterns of this fleet are also provided

Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson's disease pathogenesis

Brain tyrosinase; Neuromelanin production; Parkinson’sTirosinasa cerebral; Producció de neuromelanina; ParkinsonTirosinasa cerebral; Producción de neuromelanina; ParkinsonIn Parkinson's disease (PD) there is a selective degeneration of neuromelanin-containing neurons, especially substantia nigra dopaminergic neurons. In humans, neuromelanin accumulates with age, the latter being the main risk factor for PD. The contribution of neuromelanin to PD pathogenesis remains unknown because, unlike humans, common laboratory animals lack neuromelanin. Synthesis of peripheral melanins is mediated by tyrosinase, an enzyme also present at low levels in the brain. Here we report that overexpression of human tyrosinase in rat substantia nigra results in age-dependent production of human-like neuromelanin within nigral dopaminergic neurons, up to levels reached in elderly humans. In these animals, intracellular neuromelanin accumulation above a specific threshold is associated to an age-dependent PD phenotype, including hypokinesia, Lewy body-like formation and nigrostriatal neurodegeneration. Enhancing lysosomal proteostasis reduces intracellular neuromelanin and prevents neurodegeneration in tyrosinase-overexpressing animals. Our results suggest that intracellular neuromelanin levels may set the threshold for the initiation of PD

Age-dependent multisystem parkinsonian features in a novel neuromelanin-producing transgenic mouse model

Trabajo presentado en el 19th National Meeting of the Spanish Society of Neuroscience, celebrado en Lleida (España), del 3 al 5 de noviembre de 2021Parkinson’s disease (PD) is characterized by a preferential degeneration of neurons that accumulate with age the pigment neuromelanin, especially neurons from substantia nigra (SN) and locus coeruleus (LC). We aim to characterize the consequences of age-dependent intracellular neuromelanin accumulation in catecholaminergic neuronal populations to understand the relationship between this process and the vulnerability of these cells in PD, as well as its impact on healthy brain aging. We previously generated a rat model exhibiting progressive unilateral SN production of neuromelanin that showed parkinsonian-like neuropathology and motor deficits1. Here, we generated a new neuromelanin-producing rodent model, based on the tissue-specific constitutive expression of human tyrosinase (hTyr) under the tyrosine hydroxylase (TH) promoter (Tg-TH-hTyr), that mimics the bilateral distribution of pigmentation within the aging human brain (i.e. catecholaminergic groups A1-A142). In parallel to neuromelanin intracellular buildup, Tg-TH-hTyr mice exhibited major PD features, including motor and non-motor behavioral alterations, inclusion body formation and degeneration of specific catecholaminergic neuronal groups. Genome-wide transcriptomic analysis of neuromelanin-laden neurons revealed alterations in PD-related biological pathways that correlate with human PD postmortem studies. Our results show that modelling human neuromelanin accumulation in rodents leads to age-dependent catecholaminergic dysfunction and molecular alterations resulting in motor and non-motor deficits, which is relevant to PD pathology and brain aging.Peer reviewe

Transcriptomic changes linked to age-dependent neuromelanin accumulation in a new Parkinson's disease mouse model

Resumen del trabajo presentado en el 50th Annual Meeting Society for Neuroscience, celebrado de forma virtual del 8 al 11 de noviembre de 2021In Parkinson's disease (PD) there is a preferential degeneration of neuromelanin (NM)-containing neurons, especially neurons from the Substantia Nigra (SN) but also from the Ventral Tegmental Area (VTA) and Locus Coeruleus (LC). We generated a new NM-producing mouse model, based on the tissue-specific constitutive expression of human tyrosinase (hTyr) under the tyrosine hydroxylase (TH) promoter (tgNM), that mimics the distribution and age-dependent accumulation of NM in the human brain (i.e. catecholaminergic groups A1-A14). TgNM mice exhibited major PD features, including both motor and non-motor behavioral alterations, inclusion body formation, neuronal degeneration in lower brainstem areas (LC) together with neuronal dysfunction in higher brainstem areas (SN and VTA). In order to understand the mechanisms by which NM accumulation in specific brain areas ultimately interferes with the normal functioning of cells, we characterized genome-wide transcriptomic changes linked to the intracellular presence and progressive accumulation of NM in two NM-accumulating neuronal subpopulations (SN and VTA) that are known to be differentially susceptible to PD pathology. We selectively isolated single dopaminergic NM-containing neurons by laser capture microdissection from male and female wild-type and tgNM animals at 3 months, 12 months and 20 months of age (n=4-6 mice per group). We performed differential expression analysis, resulting in statistically significant differentially expressed genes at all ages (p-value<0.5). Gene-set enrichment analysis (GSEA) with Reactome Pathway Database led to the identification of altered biological pathways in tgNM related to neuroinflammation, vesicle-mediated transport and lipid metabolism, transcription and translation, mitochondrial function and cell cycle (senescence) (False Discovery Rate<0.05). Targeted-based validation of candidate RNA species was performed in microdissected samples by quantitative real-time PCR and candidate biological pathways were validated at the protein level by western blot in dissected ventral midbrain tissues from biological replicates. The transcriptomic profiles identified in this project contribute to our understanding of selective vulnerability in PD and brain aging, and points to key biological pathways and molecular targets in prodromal and early PD

Hydrography applied to the mapping of submarine volcanoes

Technical advances in hydrographic studies of the seafloor and the progressive use of these techniques in oceanographic expeditions with scientific objectives, is generating greater collaborations between the hydrographic and oceanographic institutions. Coordination between the different institutions and the use of IHO criteria in the acquisition of bathymetric data in oceanographic expeditions, allow regional hydrographic offices to have an additional source of data for the improvement of the navigation charts. Meanwhile the Oceanographic Institutions will benefit by having validated bathymetric data of high precision. This product is of great interest in studies of submarine geological hazards where is necessary to have a very detailed knowledge of the seabed to determine possible morphological changes associated with the risk processes and the possible active structures. In addition, monitoring of active volcanoes need to have a good knowledge of changes in the physico-chemical properties of the water column, the possible changes in low intensity emissions (hot water, gas) can be detected with these studies in the overlying water masses.Versión del edito