Calidad de vida de los pacientes afectados de trastornos de la alimentación

ResumenObjetivoAnalizar la calidad de vida percibida de pacientes ambulatorios con trastornos de la alimentación en relación a la gravedad de su sintomatología y en comparación a otros trastornos psiquiátricos y con la población general.MétodosEstudio descriptivo transversal de la calidad de vida de 180 pacientes reclutados en una unidad de trastornos de la alimentación. Para estudiar diferentes aspectos de la calidad de vida relacionada con la salud, se utilizaron los cuestionarios SF-36, EAT y HAD. Los resultados del SF-36 fueron comparados con los de una muestra de la población general del mismo sexo y edad, así como con otros estudios de trastornos psiquiátricos en los que se utilizó el SF-36.ResultadosLos pacientes con trastornos de la alimentación presentaron peor calidad de vida que la población general de su mismo sexo y edad y similar a la de pacientes con otros trastornos psiquiátricos, como esquizofrenia, depresión y trastornos de pánico. No se apreciaron diferencias significativas entre los pacientes con diagnóstico de anorexia restrictiva, anorexia purgativa y bulimia. Las áreas del SF-36 más afectadas fueron salud mental, rol emocional y vitalidad.ConclusionesEste estudio muestra la gravedad de estos trastornos, que tienen una gran incidencia entre mujeres jóvenes en edad escolar y laboral. Esto supone un grave problema de salud pública y plantea la necesidad de una asistencia especializada.SummaryObjectiveTo evaluate the quality of life of ambulatory patients with eating disorders in relation to the severity of their symptomatology and in comparison with other psychiatric disorders and general population values.MethodsCross-sectional descriptive study of the quality of life of 180 patients recruited at an eating disorders unit. In order to study different aspects of their Health Related Quality of Life, the SF-36, the EAT and the HAD questionnaires were used. The results of the SF-36 were compared to population values of the same gender and age, and to other studies of psychiatric disorders where the SF-36 questionnaire was used.ResultsPatients with eating disorders presented worse quality of life than the general population of the same gender and age, and similar to patients with other psychiatric diagnoses, as schizophrenia, depression or panic disorder. No significant differences were found between patients with diagnoses of restrictive anorexia, purgative anorexia and bulimia. Mental health, rol emotional and vitality were the most affected areas of the SF-36.ConclusionsThis study shows the severity of these disorders, which have a special incidence in young active women. This fact is becoming an important public health problem and raises the need of specialised assistance

Variations in the contents of vitamins A and e during the ripening of cheeses with different compositions

We investigated the composition in vitamins A and E of cheeses made from the milks of ewes, goats and cows. A total of 84 cheeses of known composition were prepared and controlled to determine the influence of different factors, e.g. the variable proportions of cow’s, ewe’s, and goat’s milks, seasonality (winter/summer), and evolution during the course of ripening. The variable proportions of milk from the different species did not vary in either the amount of vitamin A or that of vitamin E in the cheeses. Seasonality and ripening were seen to have a significant effect on the concentration of vitamin

Changes in the mineral content in cheeses of different compositions during 6 months of ripening

The mineral content of cheese depends on the origin of the milk (cow, ewe, goat) and its ripening. In this work the effect of different factors on the mineral composition and the correlation between minerals (Ca, Fe, Mg, K, Na, and Zn) and the type of milk used are studied. The One-Way ANOVA procedure revealed that the effect of cow’s milk was statistically significant on Fe, K, P, and Zn; goat’s milk was statistically significant for Fe and Mg, and ewe’s milk was statistically significant for K. The effect of the ripening time was statistically significant in all cases, except for Zn; the effect of the season was statistically significant for K, Mg and P and the effect of the year was statistically significant in the case of K, Na, P, and Zn. The percentage of cow’s cheese was positively correlated with K and P; the percentage of ewe’s cheese was negatively correlated with K, Mg, Na, and P and the percentage of goat’s cheese was negatively correlated with Na, and P

Seasonal evolution of hydrophilic and hydrophobic peptide contents in cheeses made from ewe's goat's or cow's milk

Proteolysis is the principal and most complex biochemical event occurring during the maturation of the majority of ripened cheese varieties. In addition to softening the cheese body, proteolysis influences the development of cheese flavour via the formation of amino acid and peptides which make a direct contribution to flavour. Goat, cow and sheep cheeses have been elaborated with raw milk and calf rennet. The extent of proteolysis was monitored over six months of ripening and means of HPLC peptide profile analysis. The influence of season on the changes in hydrophobic and hydrophilic peptides and the HO/HI ratio during the ripening of the cheeses were studie

Natural coastal risks and the Coastal Zone Integrated Management

An analysis of the main natural risk factors of the Peninsula of Hicacos, on the coast center-west of Cuba is submitted. From an exhaustive bibliographic review, first it is presented a physical-geographical and socio-economic characterization of the peninsula of Hicacos, and on this basis are identified geological, geomorphological and hydrometeorological factors that determine natural hazards in the area under study. In particular an analysis of probabilities of extreme winds in the past 200 years associated with hurricanes, and the heights and periods of waves on the coast of the peninsula to different periods of return is materialize. Also it´s includes a brief analysis of the endogenous risks, and conclude that the hurricanes, the severe local storms and the frontal systems are the main natural dangers that affect the Peninsula. Finally the value of the MIZC for the study, prevision and confrontation of the natural risk is argued, and the positive experience of the application of that approach in the beach of Varadero.Se presenta un análisis de los principales factores de riesgos naturales de la Península de Hicacos, en la costa centro-occidental de Cuba. A partir de una revisión bibliográfica exhaustiva, se presenta primero una caracterización físico-geográfica y socio-económica de la península de Hicacos y sobre esta base se identifican los factores geológicos, geomorfológicos e hidrometeorológicos que condicionan los riesgos naturales en la zona objeto de estudio. En particular se realiza un análisis de probabilidades de los vientos extremos en los últimos 200 años asociados a los huracanes, y de las alturas y periodos del oleaje en el litoral de la península para diferentes periodos de retorno. Se incluye un breve análisis de los riesgos endógenos, y se concluye que son los huracanes, las tormentas locales severas y los frentes fríos los principales peligros naturales que afectan la a Península. Finalmente, se argumenta el valor del enfoque de MIZC para el estudio, previsión y enfrentamiento de los riesgos naturales, y se expone la positiva experiencia de aplicación de tal enfoque en la playa de Varadero.Ciencias Experimentale

Natural coastal risks and the Coastal Zone Integrated Management

An analysis of the main natural risk factors of the Peninsula of Hicacos, on the coast center-west of Cuba is submitted. From an exhaustive bibliographic review, first it is presented a physical-geographical and socio-economic characterization of the peninsula of Hicacos, and on this basis are identified geological, geomorphological and hydrometeorological factors that determine natural hazards in the area under study. In particular an analysis of probabilities of extreme winds in the past 200 years associated with hurricanes, and the heights and periods of waves on the coast of the peninsula to different periods of return is materialize. Also it´s includes a brief analysis of the endogenous risks, and conclude that the hurricanes, the severe local storms and the frontal systems are the main natural dangers that affect the Peninsula. Finally the value of the MIZC for the study, prevision and confrontation of the natural risk is argued, and the positive experience of the application of that approach in the beach of Varadero.Se presenta un análisis de los principales factores de riesgos naturales de la Península de Hicacos, en la costa centro-occidental de Cuba. A partir de una revisión bibliográfica exhaustiva, se presenta primero una caracterización físico-geográfica y socio-económica de la península de Hicacos y sobre esta base se identifican los factores geológicos, geomorfológicos e hidrometeorológicos que condicionan los riesgos naturales en la zona objeto de estudio. En particular se realiza un análisis de probabilidades de los vientos extremos en los últimos 200 años asociados a los huracanes, y de las alturas y periodos del oleaje en el litoral de la península para diferentes periodos de retorno. Se incluye un breve análisis de los riesgos endógenos, y se concluye que son los huracanes, las tormentas locales severas y los frentes fríos los principales peligros naturales que afectan la a Península. Finalmente, se argumenta el valor del enfoque de MIZC para el estudio, previsión y enfrentamiento de los riesgos naturales, y se expone la positiva experiencia de aplicación de tal enfoque en la playa de Varadero.Ciencias Experimentale

Natural coastal risks and the Coastal Zone Integrated Management

An analysis of the main natural risk factors of the Peninsula of Hicacos, on the coast center-west of Cuba is submitted. From an exhaustive bibliographic review, first it is presented a physical-geographical and socio-economic characterization of the peninsula of Hicacos, and on this basis are identified geological, geomorphological and hydrometeorological factors that determine natural hazards in the area under study. In particular an analysis of probabilities of extreme winds in the past 200 years associated with hurricanes, and the heights and periods of waves on the coast of the peninsula to different periods of return is materialize. Also it´s includes a brief analysis of the endogenous risks, and conclude that the hurricanes, the severe local storms and the frontal systems are the main natural dangers that affect the Peninsula. Finally the value of the MIZC for the study, prevision and confrontation of the natural risk is argued, and the positive experience of the application of that approach in the beach of Varadero.Se presenta un análisis de los principales factores de riesgos naturales de la Península de Hicacos, en la costa centro-occidental de Cuba. A partir de una revisión bibliográfica exhaustiva, se presenta primero una caracterización físico-geográfica y socio-económica de la península de Hicacos y sobre esta base se identifican los factores geológicos, geomorfológicos e hidrometeorológicos que condicionan los riesgos naturales en la zona objeto de estudio. En particular se realiza un análisis de probabilidades de los vientos extremos en los últimos 200 años asociados a los huracanes, y de las alturas y periodos del oleaje en el litoral de la península para diferentes periodos de retorno. Se incluye un breve análisis de los riesgos endógenos, y se concluye que son los huracanes, las tormentas locales severas y los frentes fríos los principales peligros naturales que afectan la a Península. Finalmente, se argumenta el valor del enfoque de MIZC para el estudio, previsión y enfrentamiento de los riesgos naturales, y se expone la positiva experiencia de aplicación de tal enfoque en la playa de Varadero.Ciencias Experimentale

Natural coastal risks and the Coastal Zone Integrated Management

An analysis of the main natural risk factors of the Peninsula of Hicacos, on the coast center-west of Cuba is submitted. From an exhaustive bibliographic review, first it is presented a physical-geographical and socio-economic characterization of the peninsula of Hicacos, and on this basis are identified geological, geomorphological and hydrometeorological factors that determine natural hazards in the area under study. In particular an analysis of probabilities of extreme winds in the past 200 years associated with hurricanes, and the heights and periods of waves on the coast of the peninsula to different periods of return is materialize. Also it´s includes a brief analysis of the endogenous risks, and conclude that the hurricanes, the severe local storms and the frontal systems are the main natural dangers that affect the Peninsula. Finally the value of the MIZC for the study, prevision and confrontation of the natural risk is argued, and the positive experience of the application of that approach in the beach of Varadero.Se presenta un análisis de los principales factores de riesgos naturales de la Península de Hicacos, en la costa centro-occidental de Cuba. A partir de una revisión bibliográfica exhaustiva, se presenta primero una caracterización físico-geográfica y socio-económica de la península de Hicacos y sobre esta base se identifican los factores geológicos, geomorfológicos e hidrometeorológicos que condicionan los riesgos naturales en la zona objeto de estudio. En particular se realiza un análisis de probabilidades de los vientos extremos en los últimos 200 años asociados a los huracanes, y de las alturas y periodos del oleaje en el litoral de la península para diferentes periodos de retorno. Se incluye un breve análisis de los riesgos endógenos, y se concluye que son los huracanes, las tormentas locales severas y los frentes fríos los principales peligros naturales que afectan la a Península. Finalmente, se argumenta el valor del enfoque de MIZC para el estudio, previsión y enfrentamiento de los riesgos naturales, y se expone la positiva experiencia de aplicación de tal enfoque en la playa de Varadero.Ciencias Experimentale

Structural basis for inhibition of the histone chaperone activity of SET/TAF-Iß by cytochrome c

Chromatin is pivotal for regulation of the DNA damage process insofar as it influences access to DNA and serves as a DNA repair docking site. Recent works identify histone chaperones as key re- gulators of damaged chromatin’s transcriptional activity. However, understanding how chaperones are modulated during DNA damage response is still challenging. This study reveals that the histone chap- erone SET/TAF-Iß interacts with cytochrome c following DNA damage. Specifically, cytochrome c is shown to be translocated into cell nuclei upon induction of DNA damage, but not upon stimulation of the death receptor or stress-induced pathways. Cytochrome c was found to competitively hinder binding of SET/TAF-Iß to core histones, thereby locking its histone-binding domains and inhibiting its nucle- osome assembly activity. In addition, we have used NMR spectros- copy, calorimetry, mutagenesis, and molecular docking to provide an insight into the structural features of the formation of the complex between cytochrome c and SET/TAF-Iß. Overall, these findings estab- lish a framework for understanding the molecular basis of cyto- chrome c-mediated blocking of SET/TAF-Iß, which subsequently may facilitate the development of new drugs to silence the oncogenic effect of SET/TAF-Iß’s histone chaperone activity