11,613 research outputs found
Testing the viability of the interacting holographic dark energy model by using combined observational constraints
Using the data coming from the new 182 Gold type Ia supernova samples, the
shift parameter of the Cosmic Microwave Background given by the three-year
Wilkinson Microwave Anisotropy Probe observations, and the baryon acoustic
oscillation measurement from the Sloan Digital Sky Survey, and lookback
time measurements, we have performed a statistical joint analysis of the
interacting holographic dark energy model. Consistent parameter estimations
show us that the interacting holographic dark energy model is a viable
candidate to explain the observed acceleration of our universe.Comment: 15 pages, 9 figures, accepted for publication in JCA
Depletion of pre-mRNA splicing factor Cdc5L inhibits mitotic progression and triggers mitotic catastrophe.
Disturbing mitotic progression via targeted anti-mitotic therapy is an attractive strategy for cancer treatment. Therefore, the exploration and elucidation of molecular targets and pathways in mitosis are critical for the development of anti-mitotic drugs. Here, we show that cell division cycle 5-like (Cdc5L), a pre-mRNA splicing factor, is a regulator of mitotic progression. Depletion of Cdc5L causes dramatic mitotic arrest, chromosome misalignments and sustained activation of spindle assembly checkpoint, eventually leading to mitotic catastrophe. Moreover, these defects result from severe impairment of kinetochore-microtubule attachment and serious DNA damage. Genome-wide gene expression analysis reveals that Cdc5L modulates the expression of a set of genes involved in the mitosis and the DNA damage response. We further found that the pre-mRNA splicing efficiency of these genes were impaired when Cdc5L was knocked down. Interestingly, Cdc5L is highly expressed in cervical tumors and osteosarcoma. Finally, we demonstrate that downregulation of Cdc5L decreases the cell viability of related tumor cells. These results suggest that Cdc5L is a key regulator of mitotic progression and highlight the potential of Cdc5L as a target for cancer therapy
Interacting holographic dark energy model and generalized second law of thermodynamics in non-flat universe
In the present paper we consider the interacting holographic model of dark
energy to investigate the validity of the generalized second laws of
thermodynamics in non-flat (closed) universe enclosed by the event horizon
measured from the sphere of the horizon named . We show that for as the
system's IR cut-off the generalized second law is respected for the special
range of the deceleration parameter.Comment: 11 pages, no figure
Reconstructing the properties of dark energy from recent observations
We explore the properties of dark energy from recent observational data,
including the Gold Sne Ia, the baryonic acoustic oscillation peak from SDSS,
the CMB shift parameter from WMAP3, the X-ray gas mass fraction in cluster and
the Hubble parameter versus redshift. The model with curvature
and two parameterized dark energy models are studied. For the
model, we find that the flat universe is consistent with observations at the
confidence level and a closed universe is slightly favored by these
data. For two parameterized dark energy models, with the prior given on the
present matter density, , with ,
and , our result seems to suggest that the
trend of dependence for an evolving dark energy from a
combination of the observational data sets is model-dependent.Comment: 16 pages, 15 figures, To appear in JCA
The Holographic Model of Dark Energy and Thermodynamics of Non-Flat Accelerated Expanding Universe
Motivated by recent results on non-vanishing spatial curvature \cite{curve}
we employ the holographic model of dark energy to investigate the validity of
first and second laws of thermodynamics in non-flat (closed) universe enclosed
by apparent horizon and the event horizon measured from the sphere of
horizon named . We show that for the apparent horizon the first law is
roughly respected for different epochs while the second laws of thermodynamics
is respected while for as the system's IR cut-off first law is broken down
and second law is respected for special range of deceleration parameter. It is
also shown that at late-time universe is equal to and the
thermodynamic laws are hold, when the universe has non-vanishing curvature.
Defining the fluid temperature to be proportional to horizon temperature the
range for coefficient of proportionality is obtained provided that the
generalized second law of thermodynamics is hold.Comment: 12 pages, no figure, abstract and text extended, references added,
accepted for publication in JCA
Holographic Dark Energy Scenario and Variable Modified Chaplygin Gas
In this letter, we have considered that the universe is filled with normal
matter and variable modified Chaplygin gas. Also we have considered the
interaction between normal matter and variable modified Chaplygin gas in FRW
universe. Then we have considered a correspondence between the holographic dark
energy density and interacting variable modified Chaplygin gas energy density.
Then we have reconstructed the potential of the scalar field which describes
the variable modified Chaplygin cosmology.Comment: 4 latex pages, no figures, RevTeX styl
The DArk Matter Particle Explorer mission
The DArk Matter Particle Explorer (DAMPE), one of the four scientific space
science missions within the framework of the Strategic Pioneer Program on Space
Science of the Chinese Academy of Sciences, is a general purpose high energy
cosmic-ray and gamma-ray observatory, which was successfully launched on
December 17th, 2015 from the Jiuquan Satellite Launch Center. The DAMPE
scientific objectives include the study of galactic cosmic rays up to
TeV and hundreds of TeV for electrons/gammas and nuclei respectively, and the
search for dark matter signatures in their spectra. In this paper we illustrate
the layout of the DAMPE instrument, and discuss the results of beam tests and
calibrations performed on ground. Finally we present the expected performance
in space and give an overview of the mission key scientific goals.Comment: 45 pages, including 29 figures and 6 tables. Published in Astropart.
Phy
Measurement of the branching fractions of psi(2S) -> 3(pi+pi-) and J/psi -> 2(pi+pi-)
Using data samples collected at sqrt(s) = 3.686GeV and 3.650GeV by the BESII
detector at the BEPC, the branching fraction of psi(2S) -> 3(pi+pi-) is
measured to be [4.83 +- 0.38(stat) +- 0.69(syst)] x 10^-4, and the relative
branching fraction of J/psi -> 2(pi+pi-) to that of J/psi -> mu+mu- is measured
to be [5.86 +- 0.19(stat) +- 0.39(syst)]% via psi(2S) -> (pi+pi-)J/psi, J/psi
-> 2(pi+pi-). The electromagnetic form factor of 3(pi+pi-) is determined to be
0.21 +- 0.02 and 0.20 +- 0.01 at sqrt(s) = 3.686GeV and 3.650GeV, respectively.Comment: 17pages, 7 figures, submitted to Phys. Rev.
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