MBD3 as a Potential Biomarker for Colon Cancer: Implications for Epithelial-Mesenchymal Transition (EMT) Pathways

The tumor EMT is a crucial event in tumor pathogenesis and progression. Previous research has established MBD3’s significant role in pancreatic cancer EMT. However, MBD3’s precise role in colon cancer remains unclear and warrants further investigation. Pan-cancer analysis revealed MBD3’s differential expression in various tumors and its significant association with tumor occurrence, growth, and progression. Moreover, analysis of single-cell sequencing and clinical data for colon cancer revealed MBD3 expression’s negative correlation with clinical indicators such as survival prognosis. Functional enrichment analysis confirmed the association between MBD3 and EMT in colon cancer. Pathological examinations, western blotting, and qRT-PCR in vitro and in vivo validated MBD3’s differential expression in colon cancer. Transwell, CCK-8, clone formation, and in vivo tumorigenesis experiments confirmed MBD3’s impact on migration, invasion, and proliferation. Our findings demonstrate MBD3 as a potential prognostic marker and therapeutic target for colon cancer

The relationship between the disability prevalence of cataracts and ambient erythemal ultraviolet radiation in China.

In Western countries, ultraviolet (UV)-induced skin cancer has been studied extensively regarding the high incidence of skin cancers in the white population; however, for people of color, cataracts are the main public health issue in relation to increased ambient ultraviolet radiation (UVR). To our knowledge, few studies have been conducted examining the relationship between cataracts and ambient UVR in China. In this study, we aimed to explore the relationship between and the factors influencing the disability prevalence of cataracts and annual ambient erythemal UVR exposure in 31 regions of China. The data used to determine the disability prevalence of cataracts was obtained from the Second China National Sample Survey on Disability. The regional annual erythemal UVR was calculated using Geographic Information System (GIS) methods based on data from the National Aeronautics and Space Administration (NASA) database. The relationship between the disability prevalence of cataracts and the annual ambient erythemal UVR was examined by using logistic regression. Both the age-standardized disability prevalence of cataracts (OR = 3.97, 95%CI 1.30-12.13, per 100KJ/m(2) increase in annual ambient erythemal UVR) and the disability prevalence of cataracts among a population ≥65 years old (OR = 3.97, 95%CI 1.30-12.13, per 100KJ/m(2) increase in annual ambient erythemal UVR) were higher in association with higher ambient erythemal UVR. Regions with higher urbanization and educational levels had lower disability prevalence of cataracts. We found positive associations of the age-standardized disability prevalence of cataracts and the disability prevalence of cataracts among a population ≥65 years old with ambient erythemal UVR in 31 regions of China

Illustration of the divisions of the three latitude groups.

<p>Note: Regions with green, red, and yellow borders are defined as latitude group 1, latitude group 2 and latitude group 3, respectively.</p

Annual ambient erythemal UVR of 31 regions in different decades in China [sorted by the average ambient erythemal UVR (KJ/m²)].

<p>Annual ambient erythemal UVR of 31 regions in different decades in China [sorted by the average ambient erythemal UVR (KJ/m²)].</p

Comparison of the age-standardized disability prevalence of cataracts, the disability prevalence of cataracts among a population ≥65 years old and the ambient erythemal UVR among the three latitude groups.

*<p>Difference is statistically significant compared to group 3, P<0.017.</p>**<p>Difference is statistically significant compared to group 3, P<0.001.</p

Map of China with the 31 regions included in the present study.

<p>Note: Taiwan, Hong Kong, and Macau were not included in the Second China National Sample Survey on Disability and thus were not included in our analyses. Cited from the National Administration of Surveying, Mapping and Geoinformation website, 2007. Standard map service. Available: <a href="http://www.sbsm.gov.cn/article/zxbs/dtfw//" target="_blank">http://www.sbsm.gov.cn/article/zxbs/dtfw//</a> [Accessed 31 August 2011].</p

Illustration of the divisions of the three altitude groups.

<p>Note: Regions with green, red, and yellow borders are defined as altitude group 1, altitude group 2 and altitude group 3, respectively.</p

Comparison of the age-standardized disability prevalence of cataracts, the disability prevalence of cataracts among a population ≥65 years old and the ambient erythemal UVR among the three altitude groups.

*<p>Difference is statistically significant compared to group 1, P<0.017.</p

Scatter plot of the relationship between the age-standardized disability prevalence of cataracts (y) and the average annual ambient erythemal UVR (x) in 31 regions in China.

<p>Scatter plot of the relationship between the age-standardized disability prevalence of cataracts (y) and the average annual ambient erythemal UVR (x) in 31 regions in China.</p

Scatter plot of the relationship between the disability prevalence of cataracts among a population ≥65 years old (y) and the average annual ambient erythemal UVR (x) in 31 regions in China.

<p>Scatter plot of the relationship between the disability prevalence of cataracts among a population ≥65 years old (y) and the average annual ambient erythemal UVR (x) in 31 regions in China.</p