Gastric cancer prevention from the point of helicobacter

WOS: 000345025900038PubMed ID: 25254545When the first cancer estimates of world were made in 1975, gastric cancer (GC) was the most common neoplasm, making 70% of the total. Although its rate decreased to 6.8% in 2012, it is still the fifth most common malignancy after cancers of the lung, breast, colo-rectum, and prostate and the third leading cause of cancer death in both sexes worldwide (8.8%, 723,000 deaths) (1). Proximal (cardia) and distal (non-cardia) gastric adenocarcinomas have different epidemiological and clinical features. Although there is an increase in proximal GCs, most of the GCs are still distally located, and intestinal-type. H. pylori is an established trigger of gastric carcinogenesis; reversibility of precancerous conditions, including intestinal metaplasia (IM), after eradication treatment is a hot topic for research. Therefore, we read with great interest the study by Galiatsatos P et al. (2) on the sensitivity of gastric biopsy for H. pylori detection in the presence of IM. The data have once again emphasized the importance of using non-invasive tests and histopathology together in the presence of gastric IM

1970-90 Türkiye Gazeteciler Sendikası Ankara Şubesi faaliyetleri

Ankara : İhsan Doğramacı Bilkent Üniversitesi İktisadi, İdari ve Sosyal Bilimler Fakültesi, Tarih Bölümü, 2015.This work is a student project of the The Department of History, Faculty of Economics, Administrative and Social Sciences, İhsan Doğramacı Bilkent University.by Emiroğlu, Kudret

Galeazzi Fracture at the Driver: Case Report

Galeazzi fracture is described as fracture pattern, which includes radius shaft fractures with distal radioulnar joint dislocation. The most common etiologies of Galeazzi fracture in literature are fall from the high distance, traffic accidents, and job accidents. On the other hand, Galeazzi fracture, which is formed as a result of a traffic accident, such as in our case, is rarely encountered in the literature. We believe that alongside the security belt and steering wheel mark which identifies the driver, Galeazzi fracture also might be beneficial in the identification of the driver in forensics evaluations

Türk toplumu örnekleminde alkole bağlı olmayan steatohepatit hastalığının demir yüklenmesi ve insülin direnci ile ilişkisi

Aim: We investigated the role ofthe H63D mutation on the development of hepatic iron overload and hepatic injury in non-alcoholic Steatohepatitis patients and its association with insulin resistance and metabolic alterations. Material and Methods: Thirty-two patients with NASH, who were diagnosed at Hacettepe University Gastroenterology Outpatient Clinic depending on clinic and laboratory findings, were included into study. Metabolic syndrome was sought. Waist hip ratio and body mass index were calculated. H63D gene mutation, iron level at serum and liver biopsy specimens and histopathologic exam on liver biopsy specimens were studied in study group. Fasting and post-prandial blood sugar, lipid profile, 75-gr-glucose tolerance test and HOMA insulin resistance were measured to document the insulin resistance and metabolic syndrome. Results: Thirty-two patients with mean body mass index was 28.1 kg/m2i3,3 were included in study. Hypertension, obesity, hypercholesterolemia, hypertriglyceridemia, insulin resistance were found at 25 %, 37 %, 56 %, 28 and 39 %, respectively. Serum ferritin and transferrin saturation values were within normal limits in all but except patients. Hepatic iron concentration was 1600ug in 12 (41%) of patients. H63D mutation was homozygote in (3%) and heterozygote 12 (40%) patients. Therefore the H63D allele frequencies were 3.3% for homozygous, 20% for heterozygous and as total 23.4%. The patients with H63D mutation had normal serum and tissue iron parameters. There was no statistically significant relationship between H63D mutation and histopathological findings. Two hour blood sugar levels were higher in Stage patients than in Stage patients (p=0.05), and also higher in Class patients than in Class S3 patients (p=0.05). Conclusion: The H63D mutation did not affected either serum iron parameters or histopathology. However, the insulin resistance was related with fibrosis in non-alcoholic steatohepatitis patients.Amaç: Bu çalışmada alkole bağlı olmayan steatohepatit (NASH) tanısı olan hastalarda H63D mutasyonunun demir yüklenmesi ve karaciğer hasarı üzerindeki etkisi; insülin direnci ve metabolik sendrom ile ilişkisi araştırıldı. Yöntem ve Gereçler: Hacettepe Üniversitesi, Gastroenteroloji polikliniğinde klinik ve laboratuar olarak NASH tanısı alan 32 hasta çalışmaya alındı. Hastalar metabolik sendrom açısından sorgulandı. Bel kalça oranı ve vücut kitle indeksleri hesaplandı. H63D gen mutasyonu, serum ve karaciğer dokusunda demir parametreleri ve boyanması; karaciğer histopatolojik özellikleri incelendi. İnsülin direnci ve metabolik sendrom ile ilişkili olarak açlık ve tokluk kan şekeri, lipid profili, 75-gr oral glukoz tolerans testi ve HOMA insulin direnci hesaplaması yapıldı. Sonuç: Ortalama vücut--kitle indeksi (VKİ) 28,1i33 kg/m2 olan 32 hasta çalışmaya alındı. Hipertansiyon (%25), obezite (%37), hiperkolesterolemi (%56), hipertrigliseridemi (%28) ve insülin direnci (%39) oldukça sıktı. İki hasta hariç tüm hastaların ferritin ve transferrin saturasyonu normaldi. Hastaların %41'inde HIC 1600 ug/g'ın üzerinde saptandı. H63D mutasyonu 12 (%40) hastada heterezigot, (%3) hastada ise homozigot saptandı. NASH hastalarında H63D alel frekansı %23,4 idi (%3,3 homozigot, %20 heterozigot). H63D mutasyonu olan hastalarda serum ve doku demir belirteçleri normal idi. H63D mutasyonu ile histopatolojik bulgular arasında ilişki saptanmadı. 2. saat kan şekeri ölçümü evre fibrozisi olan hastalarda evre olan hastalara göre, sınıf hastalarında sınıf s3 olan hastalara göre istatistiksel olarak yüksek saptandı. Sonuç: H63D mutasyonunun serum demir belirteçlerine veya histopatolojiye etkisi saptanmadı. Bununla birlikte non--alkolik steatohepatit hastalarında insülin direnci fibrosis ile iliskili bulundu