Physiological and thermographic response to heat stress in zebu cattle

AbstractThe objective of this study was to evaluate the heat tolerance of five zebu breeds using physical, physiological and hematological traits as well as thermographic responses. Forty cows of the Gir, Girolando, Nelore, Sindhi and Indubrasil breeds (eight cows each), approximately three years of age, were evaluated. Body weight, withers and hump heights as well as thoracic circumference were recorded. The density and length of the hair was obtained by collecting one square centimeter in the rump region and skin color using the CIELAB system. Rectal temperature, heart and respiratory rates were evaluated during the morning at 4:30h, and in the afternoon, at 14:30h, with six repetitions. Blood samples were collected for hematological evaluation. The surface temperature was obtained using an infrared camera FLIR® T400. Two images were taken from each animal, one laterally of the whole body and the other of the head region. Air temperature, wind speed, relative humidity were obtained from a mobile weather station. The statistics analysis included an analyzes of variance, principal factors, as well as cluster, discriminant and canonical analyzes, logistic regression and calculation of odds ratio. There were significant differences in the rectal temperature, heart and respiratory rates between breeds. Gir and Indubrasil breeds had the highest rectal temperatures. Breed was significant for surface temperatures and showed that physical and physiological factors affected breeds in different ways. Eye and brain surface temperatures were the most affected by environmental parameters. Also, environmental parameters affected packed cell volume and red cell number. Odds ratio test showed that the Gir breed was three times more likely to have higher rectal temperature compared with Sindhi as confirmed by the logistic regression. When the black globe temperature approached 35°C, the probability of the Gir animals having rectal temperatures above normal was approximately 70%. Gir was the breed least adapted to climate conditions of the experiment while the Sindhi and Girolando breeds showed the best physiological response to thermal stress

Mucosal-Associated Invariant T cells exhibit distinct functional signatures associated with protection against typhoid fever

We have previously demonstrated that Mucosal-Associated Invariant T (MAIT) cells secrete multiple cytokines after exposure to Salmonella enterica serovar Typhi (S. Typhi), the causative agent of typhoid fever in humans. However, whether cytokine secreting MAIT cells can enhance or attenuate the clinical severity of bacterial infections remain debatable. This study characterizes human MAIT cell functions in subjects participating in a wild-type S. Typhi human challenge model. Here, we found that MAIT cells exhibit distinct functional signatures associated with protection against typhoid fever. We also observed that the cytokine patterns of MAIT cell responses, rather than the average number of cytokines expressed, are more predictive of typhoid fever outcomes. These results might enable us to objectively, based on functional parameters, identify cytokine patterns that may serve as predictive biomarkers during natural infection and vaccination

Gravitational Collapse and Disk Formation in Magnetized Cores

We discuss the effects of the magnetic field observed in molecular clouds on the process of star formation, concentrating on the phase of gravitational collapse of low-mass dense cores, cradles of sunlike stars. We summarize recent analytic work and numerical simulations showing that a substantial level of magnetic field diffusion at high densities has to occur in order to form rotationally supported disks. Furthermore, newly formed accretion disks are threaded by the magnetic field dragged from the parent core during the gravitational collapse. These disks are expected to rotate with a sub-Keplerian speed because they are partially supported by magnetic tension against the gravity of the central star. We discuss how sub-Keplerian rotation makes it difficult to eject disk winds and accelerates the process of planet migration. Moreover, magnetic fields modify the Toomre criterion for gravitational instability via two opposing effects: magnetic tension and pressure increase the disk local stability, but sub-Keplerian rotation makes the disk more unstable. In general, magnetized disks are more stable than their nonmagnetic counterparts; thus, they can be more massive and less prone to the formation of giant planets by gravitational instability.Comment: Chapter 16 in "Magnetic Fields in Diffuse Media", Springer-Verlag, eds. de Gouveia Dal Pino, E., Lazarian, A., Melioli,