Stabilization of uni-directional water wave trains over an uneven bottom

We study the evolution of nonlinear surface gravity water wave packets developing from modulational instability over an uneven bottom. A nonlinear Schrödinger equation (NLSE) with coefficients varying in space along propagation is used as a reference model. Based on a low-dimensional approximation obtained by considering only three complex harmonic modes, we discuss how to stabilize a one-dimensional pattern in the form of train of large peaks sitting on a background and propagating over a significant distance. Our approach is based on a gradual depth variation, while its conceptual framework is the theory of autoresonance in nonlinear systems and leads to a quasi-frozen state. Three main stages are identified: amplification from small sideband amplitudes, separatrix crossing and adiabatic conversion to orbits oscillating around an elliptic fixed point. Analytical estimates on the three stages are obtained from the low-dimensional approximation and validated by NLSE simulations. Our result will contribute to understand the dynamical stabilization of nonlinear wave packets and the persistence of large undulatory events in hydrodynamics and other nonlinear dispersive media

15000 Ellipsoidal Binary Candidates in TESS: Orbital Periods, Binary Fraction, and Tertiary Companions

We present a homogeneously-selected sample of 15779 candidate binary systems with main sequence primary stars and orbital periods shorter than 5 days. The targets were selected from TESS full-frame image lightcurves on the basis of their tidally-induced ellipsoidal modulation. Spectroscopic follow-up suggests a sample purity of $83 \pm 13$ per cent. Injection-recovery tests allow us to estimate our overall completeness as $28 \pm 3$ per cent with $P_\mathrm{orb} < 3$ days and to quantify our selection effects. We estimate that $39 \pm 4$ per cent of our sample are contact binary systems, and we disentangle the period distributions of the contact and detached binaries. We derive the orbital period distribution of the main sequence binary population at short orbital periods, finding a distribution continuous with the log-normal distribution previously found for solar-type stars at longer periods, but with a significant steepening at $P_\mathrm{orb} \lesssim 3$ days, and a pile-up of contact binaries at $P_\mathrm{orb} \approx 0.4$ days. Companions in the period range 1--5 days are found to be an order of magnitude more frequent around stars hotter than $\approx 6250 K$ (the Kraft break) when compared to cooler stars, suggesting that magnetic braking plays an important role in shaping the temperature and period distributions. We detect resolved tertiary companions to $9.0 \pm 0.2$ per cent of our binaries with a median separation of 3200 AU. The frequency of tertiary companions rises to $29 \pm 5$ per cent among the systems with the shortest ellipsoidal periods. This large binary sample with quantified selection effects will be a powerful resource for future studies of detached and contact binary systems with $P_\mathrm{orb} < 5$ days.Comment: 27 pages, 21 figures, submitted to MNRAS. The associated sample data will be released alongside the accepted pape

Sustainable forest genetic resources programmes in the Newly Independent States of the former USSR: Proceedings of a Workshop 23-26 September 1996, Belovezha, Belarus. [Title in Russian]

This workshop was a first opportunity to meet and renew collaboration in forest genetic resources, since the dissolution of the USSR, and it benefited greatly from the expertise and the long tradition of cooperation among the participants and their institutions, which goes back to the beginning of the 1990's. The objectives were to provide an overview of the current activities, to reassess needs and priorities, and to emphasize the interest and capacities of the Newly Independent States to be proactive in international cooperation

Lag Time between Onset of First Symptom and Treatment of Retinoblastoma: An International Collaborative Study of 692 Patients from 10 Countries

BACKGROUND: The relationship between lag time and outcomes in retinoblastoma (RB) is unclear. In this study, we aimed to study the effect of lag time between onset of symptoms and diagnosis of retinoblastoma (RB) in countries based on their national-income and analyse its effect on the outcomes. METHODS: We performed a prospective study of 692 patients from 11 RB centres in 10 countries from 1 January 2019 to 31 December 2019. RESULTS: The following factors were significantly different among different countries based on national-income level: age at diagnosis of RB (p = 0.001), distance from home to nearest primary healthcare centre (p = 0.03) and mean lag time between detection of first symptom to visit to RB treatment centre (p = 0.0007). After adjusting for country income, increased lag time between onset of symptoms and diagnosis of RB was associated with higher chances of an advanced tumour at presentation (p < 0.001), higher chances of high-risk histopathology features (p = 0.003), regional lymph node metastasis (p < 0.001), systemic metastasis (p < 0.001) and death (p < 0.001). CONCLUSIONS: There is a significant difference in the lag time between onset of signs and symptoms and referral to an RB treatment centre among countries based on national income resulting in significant differences in the presenting features and clinical outcomes

The effects of breastfeeding on retinoblastoma development: Results from an international multicenter retinoblastoma survey

The protective effects of breastfeeding on various childhood malignancies have been established but an association has not yet been determined for retinoblastoma (RB). We aimed to further investigate the role of breastfeeding in the severity of nonhereditary RB development, assessing relationship to (1) age at diagnosis, (2) ocular prognosis, measured by International Intraocular RB Classification (IIRC) or Intraocular Classification of RB (ICRB) group and success of eye salvage, and (3) extraocular involvement. Analyses were performed on a global dataset subgroup of 344 RB patients whose legal guardian(s) consented to answer a neonatal questionnaire. Patients with undetermined or mixed feeding history, family history of RB, or sporadic bilateral RB were excluded. There was no statistically significant difference between breastfed and formula-fed groups in (1) age at diagnosis (p = 0.20), (2) ocular prognosis measures of IIRC/ICRB group (p = 0.62) and success of eye salvage (p = 0.16), or (3) extraocular involvement shown by International Retinoblastoma Staging System (IRSS) at presentation (p = 0.74), lymph node involvement (p = 0.20), and distant metastases (p = 0.37). This study suggests that breastfeeding neither impacts the sporadic development nor is associated with a decrease in the severity of nonhereditary RB as measured by age at diagnosis, stage of disease, ocular prognosis, and extraocular spread. A further exploration into the impact of diet on children who develop RB is warranted

The role of maternal age & birth order on the development of unilateral and bilateral retinoblastoma: a multicentre study

BACKGROUND/OBJECTIVES: Retinoblastoma is a common childhood intraocular malignancy, the bilateral form of which most commonly results from a de novo germline pathogenic variant in the RB1 gene. Both advanced maternal age and decreasing birth order are known to increase the risk of de novo germline pathogenic variants, while the influence of national wealth is understudied. This cohort study aimed to retrospectively observe whether these factors influence the ratio of bilateral retinoblastoma cases compared to unilateral retinoblastoma, thereby inferring an influence on the development of de novo germline pathogenic variants in RB1. SUBJECTS/METHODS: Data from 688 patients from 11 centres in 10 countries were analysed using a series of statistical methods. RESULTS: No associations were found between advanced maternal age, birth order or GDP per capita and the ratio of bilateral to unilateral retinoblastoma cases (p values = 0.534, 0.201, 0.067, respectively), indicating that these factors do not contribute to the development of a de novo pathogenic variant. CONCLUSIONS: Despite a lack of a definitive control group and genetic testing, this study demonstrates that advanced maternal age, birth order or GDP per capita do not influence the risk of developing a bilateral retinoblastoma

Live birth following day surgery reversal of female sterilisation in women older than 40 years: a realistic option in Australia?

The document attached has been archived with permission from the editor of the Medical Journal of Australia. An external link to the publisher’s copy is included.Objective: To determine the live birth rate following surgical reversal of sterilisation in women aged 40 years and older. Design: Retrospective cohort study of pregnancy outcome following day surgery microsurgical reversal of sterilisation performed by two reproductive microsurgeons in the private sector. Setting and patients: 47 patients (aged 40 years or older) who had reversal of sterilisation performed between 1997 and 2005 in Adelaide, South Australia (n = 35), or the Infertility Centre of St Louis, Missouri, USA (n = 12). Main outcome measures: Independently audited live birth surviving the neonatal period. Results: Of the 47 patients on whom follow-up was obtainable from the two centres, 19 (40%) had a live birth, 7 had had only a first trimester miscarriage at the time of follow-up, and 21 (44%) had failed to conceive. Age at conception ranged between 40 and 47 years. Two women had two live births following surgery. The total direct costs (Australian dollars, adjusted to 2005) in Australia were $4850 per treatment, and$11 317 per live birth. The corresponding direct cost of a single cycle of in-vitro fertilisation (IVF) in Australia has been estimated at $6940, with a cost per live birth of$97 884 for women aged 40–42 years and $182 794 for older women. Conclusion: Previously sterilised women wanting further pregnancy should be offered tubal surgery as an alternative to IVF, as it offers them the opportunity to have an entirely natural pregnancy. In settings where IVF is financially supported by government agencies or insurance, tubal reversal is a highly cost-effective strategy for the previously fertile woman.Oswald M Petrucco, Sherman J Silber, Sarah L Chamberlain, Graham M Warnes and Michael Davie

Gaia Focused Product Release: A catalogue of sources around quasars to search for strongly lensed quasars

Context. Strongly lensed quasars are fundamental sources for cosmology. The Gaia space mission covers the entire sky with the unprecedented resolution of $0.18$" in the optical, making it an ideal instrument to search for gravitational lenses down to the limiting magnitude of 21. Nevertheless, the previous Gaia Data Releases are known to be incomplete for small angular separations such as those expected for most lenses. Aims. We present the Data Processing and Analysis Consortium GravLens pipeline, which was built to analyse all Gaia detections around quasars and to cluster them into sources, thus producing a catalogue of secondary sources around each quasar. We analysed the resulting catalogue to produce scores that indicate source configurations that are compatible with strongly lensed quasars. Methods. GravLens uses the DBSCAN unsupervised clustering algorithm to detect sources around quasars. The resulting catalogue of multiplets is then analysed with several methods to identify potential gravitational lenses. We developed and applied an outlier scoring method, a comparison between the average BP and RP spectra of the components, and we also used an extremely randomised tree algorithm. These methods produce scores to identify the most probable configurations and to establish a list of lens candidates. Results. We analysed the environment of 3 760 032 quasars. A total of 4 760 920 sources, including the quasars, were found within 6" of the quasar positions. This list is given in the Gaia archive. In 87\% of cases, the quasar remains a single source, and in 501 385 cases neighbouring sources were detected. We propose a list of 381 lensed candidates, of which we identified 49 as the most promising. Beyond these candidates, the associate tables in this Focused Product Release allow the entire community to explore the unique Gaia data for strong lensing studies further.Comment: 35 pages, 60 figures, accepted for publication by Astronomy and Astrophysic