Production of nitrogen oxide derivatives under the influence of NO-synthase inhibitors and natural compounds in mice with transplanted tumors

Aim: The aim of the present study was to investigate the dynamics of nitric oxide derivative (NOD) formation in mice with transplanted tumors and to analize whether synthetic NO-synthase inhibitors, NO-donors and natural compounds could modulate NOD synthesis. Materials and Methods: In the study F1(C57BlxCBA), CBA/Lac, BDF and Balb/c mice were used. Endogenous NOD synthesis in mice with transplanted Ehrlich carcinoma (EC) and Lewis lung carcinoma (LLC) was estimated by measuring urine nitrates (NA) and nitrites (NI) excretion and their concentration in tumor tissue determined by cadmium-reduction method. Results: It is shown that EC development is accompanied by increased endogenous NOD formation whereas LLC growth — by its decrease. Total NOD excretion with urine in EC-bearing mice during tumor development was in the range of 1.1x10–7-7.0x10–6 mol/kg body weight that was 1.7–6.8 times higher than that in LLC-bearing mice. Treatment of EC-bearing animals with Nώ-nitro-L-arginine and aminoguanidine resulted in decreased NOD formation causing moderate tumor growth retardation. Effect of treatment with nitroprusside was shown to be dependent on the rout of its administration and dosage. Treatment of EC-bearing mice with picnogenol, tannic acid, spirulina and paprika enriched with selenium resulted in tumor growth inhibition at the early stage of EC growth accompanied by stimulation of endogenous NOD formation. Conclusion: Regulation of endogenous NOD formation towards normal physiological levels or hyperproduction of these compounds may result in tumor growth suppression

Биологическое значение каротиноидов

The review surveyed the carotenoids in vegetables, factors affecting their accumulation and their protective abilities against chronic diseasesВ статье представлен обзор литературы, посвященной каротиноидам овощных культур, факторам, влияющим на накопление последних, и их защитному действию против различных заболеваний человека

Многолетние луки - пища и лекарство

Vegetables are a source of vitamins, salts, acids, carbohydrates and biologically active substances which are necessary for human's vital function. Academician Pavlov I.V. asserted that life expectancy of human can be one third longer by daily consumption of fresh vegetable. The nourishing values of vegetables are composed not only of high content of carbohydrate and proteins, but also there is an extremely useful source of vitamins and ferments, microelements and biologically active substances. It should be mentioned that some of necessary substances can dissociate or transform under the thermal condition in another ones, sometime, not accessible chemical forms. Taking this into account the human's food must be enriched by vegetables that bring natural consistencies of substances. The perennial onion can be used as a vegetable with all these qualities.Овощи являются источником витаминов, солей, кислот, углеводов и биологически активных веществ, необходимых для жизнедеятельности человека. Академик И.П.Павлов утверждал, что человек может продлить свою жизнь, по крайней мере, на одну треть, если будет ежедневно питаться свежими овощами. Питательная ценность овощей обусловлена не только содержанием большого количества углеводов и белков, но и значительным количеством витаминов, ферментов, различных микроэлементов и биологически активных веществ. Однако многие из этих веществ могут распадаться или переходить в недоступную форму при термической обработке. В связи с этим исключительную ценность для питания человека представляют овощные культуры, потребляемые в свежем виде. К таким культурам относятся многолетние луки

Накопление селена листьями многолетних луков

It was determined that Selenium concentration in leaves of perennial onion was in the range of 161 to 201 mg/kg of dry matter. The highest concentration of Selenium was in leaves of Common Chives, and Siberian Chives. There was also shown that the plant treatment with Epin and Sodium Humate solutions caused the Selenium content was 1.2-1.7 times as much as it was before in leaves.Установлено, что концентрация селена в листьях изучавшихся видов многолетних луков находилась в интервале от 161 до 201 мкг/кг сухой массы. Наибольшее содержание селена выявлено у лука слизуна и лука шнитта. Показано, что обработки растений раствором эпина и гумата натрия способствовали возрастанию в зеленых листьях содержания селена в 1,2-1,7 раза

Seed oil content, fatty acids composition and antioxidant properties as affected by genotype in Allium cepa L. and perennial onion species

The antioxidant content in plant seeds is deemed to affect seed oil protection against auto-oxidation to a large extent, whereas the relationship between a strong antioxidant element such as selenium (Se) and either seed oil accumulation or fatty acids composition has not been investigated so far. The aim of the present work was to assess Se concentrations in seeds and their relationships with oil content and fatty acids composition in: a) ten Allium cepa cultivars, i. e. eight Russian and two Italian; and b) six perennial onion species (A. schoenoprasum, A. obliquum, A. altaicum, A. fistulosum, A. nutans, A. ramnósum). Fatty acids composition of Allium seed oil was determined by gas chromatography method, whereas total and water soluble Se concentration was assessed by microfluorimetric method. The oil content of Allium cepa seeds was 1.7 fold higher (10.7-16.5%) than that recorded in perennial onions (4.0-10.8%) and it was positively correlatedwith the total Se concentration. Within A. cepa, the seeds of the two Italian cultivars Ramata di Montoro and Rossa di Tropea were characterized by the highest oil content (16.5-16.6%) and oleic acid (25-27%). Linoleic (C18:2) acid was the main fatty acid, followed by oleic (C18:1) and palmitic acids (C16:0) in all cultivars. Among the perennial onion seeds, the highest oil percentage was detected in A. schoenoprasum (10.8%) and the lowest in A. ramnósum (4.0%). Compared to A.cepa cultivars, the perennial onion species showed a similar oil fatty acid composition, with the main acids being C18:2,C18:1 and C16:0 in decreasing order, a lower level of C16:0, and enhanced levels of minor SFA, such as C20:0, C22:0 and C24:0. Further differences also included decreased levels of C16:1, 11-trance C18:1 and a higher concentration of C22:1. The concentration of water soluble forms of Se in seeds was positively correlated with linoleic acid and with total phenolics. Conversely, oleic acid was negatively correlated with water soluble forms of Se

The quality of agricultural output

Vegetables definitely play a great role in food composition of a human. In countries where fruit and vegetable consumption is high, there is reduced cases of cardiovascular and cancel diseases as it was shown by epidemiological data. Vegetables bear the protective properties based on antioxidant actions of such components as vitamins, flavonoids, antozian, polyphenols and microelements including selenium, zinc, and copper and so on. The applications of stimulators of growth are safe environmental methods that can be used for improvement of yield qualities. The influence of Epin, Gumats, APIONs and other growth stimulators on antioxidant and biologically active matter contents has been studied in range of vegetable crops like perennial onion, Japanese cabbage, and bell pepper and so on

Качество овощной продукции

Vegetables definitely play a great role in food composition of a human. In countries where fruit and vegetable consumption is high, there is reduced cases of cardiovascular and cancel diseases as it was shown by epidemiological data. Vegetables bear the protective properties based on antioxidant actions of such components as vitamins, flavonoids, antozian, polyphenols and microelements including selenium, zinc, and copper and so on. The applications of stimulators of growth are safe environmental methods that can be used for improvement of yield qualities. The influence of Epin, Gumats, APIONs and other growth stimulators on antioxidant and biologically active matter contents has been studied in range of vegetable crops like perennial onion, Japanese cabbage, and bell pepper and so on.Роль овощей в питании человека несомненна. По данным эпидемиологических исследований в странах с высоким потреблением овощей и фруктов частота сердечно-сосудистых и раковых заболеваний на порядок ниже. Защитные свойства овощей связаны, прежде всего, с антиоксидантными свойствами их компонентов: витаминов, флавоноидов, антоцианов, полифенолов, ряда микроэлементов антиоксидантного действия (например, селен, цинк, медь). В качестве экологически безопасного метода повышения урожайности, устойчивости растений к заболеваниям, улучшения качества овощной продукции лидирующее место приобретают стимуляторы роста. Проведено изучение влияния Эпина, гуматов, АПИОНов и других регуляторов роста на содержание антиоксидантов и других биологически активных веществ у различных овощных культур (многолетние луки, капуста японская, перец сладкий и др.)

Biological role of carotenoids

The review surveyed the carotenoids in vegetables, factors affecting their accumulation and their protective abilities against chronic disease

Selenium accumulation in leaves of perennial onions

It was determined that Selenium concentration in leaves of perennial onion was in the range of 161 to 201 mg/kg of dry matter. The highest concentration of Selenium was in leaves of Common Chives, and Siberian Chives. There was also shown that the plant treatment with Epin and Sodium Humate solutions caused the Selenium content was 1.2-1.7 times as much as it was before in leaves

Perennial onion is a plant of nourishing and medicinal properties

Vegetables are a source of vitamins, salts, acids, carbohydrates and biologically active substances which are necessary for human's vital function. Academician Pavlov I.V. asserted that life expectancy of human can be one third longer by daily consumption of fresh vegetable. The nourishing values of vegetables are composed not only of high content of carbohydrate and proteins, but also there is an extremely useful source of vitamins and ferments, microelements and biologically active substances. It should be mentioned that some of necessary substances can dissociate or transform under the thermal condition in another ones, sometime, not accessible chemical forms. Taking this into account the human's food must be enriched by vegetables that bring natural consistencies of substances. The perennial onion can be used as a vegetable with all these qualities