Rational sequence of monoclonal antibodies in the treatment of non-resectable head and neck squamous cell carcinoma [Рациональная последовательность моноклональных антител в лечении нерезектабельного плоскоклеточного рака головы и шеи]

This article discusses current approaches to first-line chemotherapy for non-resectable head and neck squamous cell carcinoma and describes factors affecting the choice of treatment regimen according to the results of randomized clinical trials. we provide a rationale for creating a long-term strategy of chemotherapy in different clinical situations. we also report two cases of concomitant administration of cetuximab and platinum-based therapy as an example of high efficacy of monoclonal antibodies. © 2022 Farmatsiya i Farmakologiya. All rights reserved

Novel titanium (IV) complexes with 1,2-diolate ligands: Synthesis, structure and catalytic activities in ultra-high molecular weight polyethylene production

A series of titanium (IV) complexes 3a-f stabilized by 1,2-diolate ligands 2 a-e have been synthesized. Structures of complexes 3d and 3e have been determined by X-ray diffraction. Titanium atoms in these complexes have a distorted square-pyramidal environment. All resulting complexes are highly active in ethylene polymerization in the presence of {3Et2AlCl + MgBu2} or {1.5Et3Al2Cl3 + MgBu2} binary co-catalysts. In the latter case, higher molecular weights of UHMWPE samples (up to 7.7 106) are achieved. Obtained polymers are suitable for the modern processing methods – the solvent-free solid state formation of super high-strength (over 2.0 – 2.8 GPa) and high-modulus (up to 145 GPa) oriented film tapes. © 201

Novel alkoxo-titanium(IV) complexes with fluorinated 2-hydroxymethylphenol derivatives as catalysts for the formation of ultra-high molecular weight polyethylene nascent reactor powders

A series of titanium (IV) complexes 3a–g stabilized by fluorinated derivatives of 2-hydroxymethylphenol have been synthesized; their composition and structure have been confirmed by NMR, IR-spectroscopy and elemental analysis. The structures of compounds 3c, 3f and 3g have been unambiguously established by X-ray diffraction study. The complexes in the presence of a binary cocatalysts {alkyl aluminum chloride + MgBu2} catalyze ethylene polymerization to afford Ultra High Molecular Weight Polyethylene (UHMWPE). The effects of substituents in the ligands on the catalytic activity and properties of the obtained polymer – molecular weight, DSC melting behavior, and morphology of nascent reactor powders have been investigated. UHMWPE samples were processed by a solid-state uniaxial deformation into high-strength (up to 2.65 GPa) and high-modulus (over 140 GPa) oriented film tapes, which indirectly indicates a low degree of entanglements between the macromolecular chains. © 2019 Elsevier B.V

Novel titanium(IV) diolate complexes with additional O-donor as precatalyst for the synthesis of ultrahigh molecular weight polyethylene with reduced entanglement density: Influence of polymerization conditions and its implications on mechanical properties

New alkoxo-titanium(IV) complexes with diolate ligand containing additional donor oxygen atom have been synthesized from readily available and scalable precursors. The structure of complex 4 was established by X-ray diffraction. Titanium atom adopts a distorted tetrahedral geometry formed by six oxygen atoms of ligands. The resulting complexes 3–4 are moderately or highly active in ethylene polymerization in the presence of {EtnAlCl3–n + Bu2Mg} binary cocatalysts. The influence of the nature of the solvent, the organoaluminum cocatalyst and the polymerization temperature on the activity of catalytic systems, and the properties of the resulting polymers were studied. The obtained polymers are linear polyethylene of ultrahigh molecular weight (up to 5.8·106 g mol−1) with a broad molecular weight distribution. The polymers are suitable for the modern methods of polymer processing—the solventless solid-state formation of super high-strength (breaking strength up to 2.8 GPa) and high-modulus (elastic modulus up to 140 GPa) oriented films and film tapes. The possibility of scaling up the synthesis of ultrahigh molecular weight polyethylene (UHMWPE) without a significant drop in the productivity of the catalytic system and polymer properties is shown. UHMWPE samples have been investigated by small-angle X-ray scattering (SAXS) methods to study the structural changes induced by solid-state drawing of nascent reactor powders. © 2021 John Wiley & Sons, Ltd

Autoencoder-based Anomaly Detection System for Online Data Quality Monitoring of the CMS Electromagnetic Calorimeter

The CMS detector is a general-purpose apparatus that detects high-energy collisions produced at the LHC. Online Data Quality Monitoring of the CMS electromagnetic calorimeter is a vital operational tool that allows detector experts to quickly identify, localize, and diagnose a broad range of detector issues that could affect the quality of physics data. A real-time autoencoder-based anomaly detection system using semi-supervised machine learning is presented enabling the detection of anomalies in the CMS electromagnetic calorimeter data. A novel method is introduced which maximizes the anomaly detection performance by exploiting the time-dependent evolution of anomalies as well as spatial variations in the detector response. The autoencoder-based system is able to efficiently detect anomalies, while maintaining a very low false discovery rate. The performance of the system is validated with anomalies found in 2018 and 2022 LHC collision data. Additionally, the first results from deploying the autoencoder-based system in the CMS online Data Quality Monitoring workflow during the beginning of Run 3 of the LHC are presented, showing its ability to detect issues missed by the existing system