Application of Nanocomposite Coatings with Different Structural Physical and Chemical Characteristics in Tissue Engineering

The research covers the results of experimental studies of the effect character of nanocomposite coatings with different physical and chemical parameters (type, roughness, hydrophilic-hydrophobic characteristics) on structural and functional properties (adhesive potential, phenotype, gene expression) of mesenchymal stem cells (MSCs). On the tested nanocoatings (Al2O3, ZrO2, Ta2O5) the capability of oxide coating Al2O3 to enrich the in vitro cultured bone marrow (BM) with the cells of MSCs phenotype markers as well as to increase the expression rate of ido gene in them, which may extend the spectrum of their therapeutic application in clinics, has been found. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3496

Application of Nanocomposite Coatings with Different Structural Physical and Chemical Characteristics in Tissue Engineering

The research covers the results of experimental studies of the effect character of nanocomposite coatings with different physical and chemical parameters (type, roughness, hydrophilic-hydrophobic characteristics) on structural and functional properties (adhesive potential, phenotype, gene expression) of mesenchymal stem cells (MSCs). On the tested nanocoatings (Al2O3, ZrO2, Ta2O5) the capability of oxide coating Al2O3 to enrich the in vitro cultured bone marrow (BM) with the cells of MSCs phenotype markers as well as to increase the expression rate of ido gene in them, which may extend the spectrum of their therapeutic application in clinics, has been found. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3496

Theory of the first-order isostructural valence phase transitions in mixed valence compounds YbIn_{x}Ag_{1-x}Cu_{4}

For describing the first-order isostructural valence phase transition in mixed valence compounds we develop a new approach based on the lattice Anderson model. We take into account the Coulomb interaction between localized f and conduction band electrons and two mechanisms of electron-lattice coupling. One is related to the volume dependence of the hybridization. The other is related to local deformations produced by f- shell size fluctuations accompanying valence fluctuations. The large f -state degeneracy allows us to use the 1/N expansion method. Within the model we develop a mean-field theory for the first-order valence phase transition in YbInCu_{4}. It is shown that the Coulomb interaction enhances the exchange interaction between f and conduction band electron spins and is the driving force of the phase transition. A comparison between the theoretical calculations and experimental measurements of the valence change, susceptibility, specific heat, entropy, elastic constants and volume change in YbInCu_{4} and YbAgCu_{4} are presented, and a good quantitative agreement is found. On the basis of the model we describe the evolution from the first-order valence phase transition to the continuous transition into the heavy-fermion ground state in the series of compounds YbIn_{1-x}Ag_{x}Cu_{4}. The effect of pressure on physical properties of YbInCu_{4} is studied and the H-T phase diagram is found.Comment: 17 pages RevTeX, 9 Postscript figures, to be submitted to Phys.Rev.

Использование нанокомпозитных покрытий с различными физико-химическими характеристиками в тканевой инженерии

The research covers the results of experimental studies of the effect character of nanocomposite coatings with different physical and chemical parameters (type, roughness, hydrophilic-hydrophobic characteristics) on structural and functional properties (adhesive potential, phenotype, gene expression) of mesenchymal stem cells (MSCs). On the tested nanocoatings (Al2O3, ZrO2, Ta2O5) the capability of oxide coating Al2O3 to enrich the in vitro cultured bone marrow (BM) with the cells of MSCs phenotype markers as well as to increase the expression rate of ido gene in them, which may extend the spectrum of their therapeutic application in clinics, has been found. При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/30946У роботі представлено результати експериментальних досліджень характеру впливу нанокомпозитних покриттів з різними фізико-хімічними параметрами (тип, шорсткість, гідрофільно-гідрофобні характеристики) на структурні й функціональні властивості (адгезивний потенціал, фенотипія, експресія генів) мезенхімальних стромальних клітин (МСК). Із усього спектра апробованих нанопокриттів (Al2O3, Zr2, Ta2O5) встановлена здатність оксидного покриття Аl2O3 збагачувати культивований in vitro кістковий мозок (КМ) клітинами з фенотипічними маркерами МСК, а також підвищувати ступінь експресії в них гена ido, що може розширювати спектр їхнього терапевтичного застосування в клінічній практиці. При цитировании документа, используйте ссылку http://essuir.sumdu.edu.ua/handle/123456789/30946В работе представлены результаты экспериментальных исследований характера влияния нанокомпозитных покрытий с различными физико-химическими параметрами (вид, шероховатость, гидрофильно-гидрофобные характеристики) на структурные и функциональные свойства (адгезивный потенциал, фенотипия, экспрессия генов) мезенхимальных стромальных клеток (МСК). Из всего спектра апробированных нанопокрытий (Al2O3, ZrO2, Ta2O5) установлена способность оксидного покрытия Аl2O3 обогащать культивируемый in vitro костный мозг (КМ) клетками с фенотипическими маркерами МСК, а также повышать степень экспрессии в них гена ido, что может расширять спектр их терапевтического применения в клинической практике. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3094