Promoting Local Talents to Fight Local Health Issues STEP-UP in the Pacific

This manuscript introduces the abstracts for the University of Hawai\u27i at Manoa Coordinating Center

Treatment of Conjunctival Keratoacanthoma with Topical Interferon-alpha2b

Conjunctival keratoacanthoma is a rare disease which is believed to be a low-grade form of squamous cell carcinoma (SCC). Although conjunctival keratoacanthoma was primarily described almost 60 years ago, only few cases have been described in the English literature and its diagnosis and treatment guidelines are still controversial. Almost all suggested treatment options have been surgical methods and non-invasive methods have rarely been examined in treatment of this disease. Here we report an interesting case of conjunctival keratoacanthoma which was treated with topical Interferon-alpha2b. Keywords: Interferon-alpha2b; Keratoacanthoma; Conjunctival neoplams.

Computational approaches for engineering effective teams

The performance of a team depends not only on the abilities of its individual members, but also on how these members interact with each other. Inspired by this premise and motivated by a large number of applications in educational, industrial and management settings, this thesis studies a family of problems, known as team-formation problems, that aim to engineer teams that are effective and successful. The major challenge in this family of problems is dealing with the complexity of the human team participants. Specifically, each individual has his own objectives, demands, and constraints that might be in contrast with the desired team objective. Furthermore, different collaboration models lead to different instances of team-formation problems. In this thesis, we introduce several such models and describe techniques and efficient algorithms for various instantiations of the team-formation problem. This thesis consists of two main parts. In the first part, we examine three distinct team-formation problems that are of significant interest in (i) educational settings, (ii) industrial organizations, and (iii) management settings respectively. What constitutes an effective team in each of the aforementioned settings is totally dependent on the objective of the team. For instance, the performance of a team (or a study group) in an educational setting can be measured as the amount of learning and collaboration that takes place inside the team. In industrial organizations, desirable teams are those that are cost-effective and highly profitable. Finally in management settings, an interesting body of research uncovers that teams with faultlines are prone to performance decrements. Thus, the challenge is to form teams that are free of faultlines, that is, to form teams that are robust and less likely to break due to disagreements. The first part of the thesis discusses approaches for formalizing these problems and presents efficient computational methods for solving them. In the second part of the thesis, we consider the problem of improving the functioning of existing teams. More precisely, we show how we can use models from social theory to capture the dynamics of the interactions between the team members. We further discuss how teams can be modified so that the interaction dynamics lead to desirable outcomes such as higher levels of agreement or lesser tension and conflict among the team members

Failure strength of thin-walled cylindrical GFRP composite shell against static internal and external pressure for various volumetric fiber fraction

A study on a Circular cylindrical thin-walled shell failure made of GRP composite subjected to static internal and external pressure was carried out. The results were acquired using analytical and FEM simulation approaches for various volumetric fiber fractions. Fiber breakage, matrix breakage, interlaminate shear deformation, delamination shear deformation and micro buckling failure were investigated employing maximum failure criteria against internal and external pressure. One-ply cylindrical shell with fiber angle orientation of 0 degree was modeled in ABAQUS finite element simulation and the result was varied using analytical approaches. Moreover, the pressure fluctuations for various volumetric fiber fraction were quadratic according to plotted graphs. Meanwhile, MATLAB software was used for theoretical analysis. The comparison of two approaches was proved to be accurate. Subsequently, failure strength of various laminated GFRP cylindrical shell with different fiber angle orientations at each ply was studied for diverse volumetric fiber fraction factors. Stacking sequence, fiber angle orientations were mainly effective on failure strength