The Effect of Personal Health on the Formation of Human Capital: a Metasystem Approach

In article the problem of influence of the personality's health on formation of the human capital is considered. Authors have conducted theoretical researches of the existing knowledge of the human capital and justifications of influence of the personality's health on its formation are given. On the basis of the carried-out analysis it is established that now the personality's health is a significant factor of efficiency of any kind of activity and important quality of the personality, therefore, it can be considered as a factor of formation of the human capital. According to it need of determination of criteria, the indicators of health of the personality influencing formation and development of the human capital was designated

Epidemiologic Situation on Brucellosis in the Russian Federation in 2012 and Prognosis for 2013

Displayed is the analysis of epizootic and epidemic situation on brucellosis in the Russian Federation in 2012. Demonstrated is the fact that epizootic condition still remains tense. It specifies the character of epidemic manifestations. For 2013 leveling of the brucellosis incidence rate among the population of the Russian Federation is forecasted

Survey of Epizootiologic and Epidemiologic Situation on Brucellosis in the Russian Federation in 2013; Prognosis for 2014

Carried out is the analysis and assessment of epizootiologic and epidemiologic situation on brucellosis in the Russian Federation over the year 2013. It is demonstrated that on the grounds of tense epizootic situation there is a tendency to reduction in brucellosis morbidity rates among the population. Incidence rates in the North-Caucasian and Southern Federal districts remain high due to B. melitensis spp. brucellosis agent circulation. However, realization of a complex of brucellosis prophylactic measures in the territory of the Republic of Dagestan has resulted in a considerable reduction of a number of primary cases in the region. In addition, forecasted is stabilization of brucellosis morbidity rates among the population and farming animals in 2014, being estimated at 320-370 cases a year

Brucellosis Epidemiological Situation and Its Morbidity in the Russian Federation in 2011, and Prognosis for 2012

Presented is the analysis of brucellosis morbidity, both in humans and animals, in the Russian Federation in 2007-2011. Evaluated is epizootic and epidemic situation on the disease. Epidemiological situation on brucellosis in the Russian Federation remains unfavorable and has a tendency to deterioration. Moreover, it is expected that the incidence of brucellosis in humans will rise in 2012

Influence of high-intensity CO2 laser irradiation on collagen matrix composition of normotrophic skin scars (experimental study)

The experiment was carried out in 25 laboratory rats. After modeling of normotrophic cutaneous scars, the procedure of laser dermabrasion with 50 Watt carbon dioxide laser was performed in superpulse mode with impulse-pause ratio of 0,5:100 ms and 500 µm spot diameter. Morphological, immunohistochemical and morphometric examination of skin histological sections were performed. A single exposure to CO2 laser radiation in this mode resulted in the early formation of mainly type III collagen and then type I collagen in ratios approaching to the intact skin.Проведено экспериментальное исследование на 25-ти лабораторных крысах, которым после моделирования нормотрофических кожных рубцов выполняли процедуру лазерной дермабразии излучением углекислого лазера мощностью 50 Вт в суперимпульсном режиме с соотношением импульс – пауза 0,5:100 мс и диаметром пятна 0,5 мм. Проводили морфологическое, иммуногистохимическое морфометрическое исследование гистологических срезов кожи. Установлено, что однократное воздействие излучением Со2 лазера в указанных режимах приводит к образованию в ранние сроки преимущественно коллагена III типа, а затем и коллагена I типа в соотношениях, приближающихся к показателям интактной кожи

Childhood exposure due to the Chernobyl accident and thyroid cancer risk in contaminated areas of Belarus and Russia

The thyroid dose due to 131I releases during the Chernobyl accident was reconstructed for children and adolescents in two cities and 2122 settlements in Belarus, and in one city and 607 settlements in the Bryansk district of the Russian Federation. In this area, which covers the two high contamination spots in the two countries following the accident, data on thyroid cancer incidence during the period 1991-1995 were analysed in the light of possible increased thyroid surveillance. Two methods of risk analysis were applied: Poisson regression with results for the single settlements and Monte Carlo (MC) calculations for results in larger areas or sub-populations. Best estimates of both methods agreed well. Poisson regression estimates of 95% confidence intervals (CIs) were considerably smaller than the MC results, which allow for extra-Poisson uncertainties due to reconstructed doses and the background thyroid cancer incidence. The excess absolute risk per unit thyroid dose (EARPD) for the birth cohort 1971-1985 by the MC analysis was 2.1 (95% CI 1.0-4.5) cases per 10(4) person-year Gy. The point estimate is lower by a factor of two than that observed in a pooled study of thyroid cancer risk after external exposures. The excess relative risk per unit thyroid dose was 23 (95% CI 8.6-82) Gy(-1). No significant differences between countries or cities and rural areas were found. In the lowest dose group of the settlements with an average thyroid dose of 0.05 Gy the risk was statistically significantly elevated. Dependencies of risks on age-at-exposure and on gender are consistent with findings after external exposures

Reparative processes in liver after laser exposure of bone marrow localization zones

We investigated the features of reparative process in the resected liver after laser irradiation of the zones of red bone marrow localization In rat experiment, the wedge-shaped resection of a liver lobe was performed. Infrared laser was applied for 5 days after the operation. The hystological analysis of liver specimens demonstrated the increase in hepatocyte proliferation with the increase in the ki-67 index and the nuclear-cytoplasmic ratio, the increase in binuclear hepatocytes number, the increase in the expression level of VEGF and Hsp 70 in the laser treatment group that is the evidence of successful recovery process and neoangiogenesis. The activation of hepatic tissue regeneration after laser irradiation of bone marrow localization zones may be the basis for the development of methods for treatment of liver disease patients.Исследованы особенности репаративных процессов в резецированной печени после лазерного воздействия на зоны локализации красного костного мозга. В эксперименте на крысах моделировали клиновидную резекцию доли печени. Лазерное воздействие осуществляли инфракрасным лазером в течение 5 суток после операции. После морфометрического анализа препаратов печени отмечено усиление пролиферации гепатоцитов с повышением индекса кi-67 и ядерно-цитоплазматического отношения, увеличение содержания двуядерных гепатоцитов, повышение уровня экспрессии VEGF и Hsp 70, что является свидетельством успешно протекающих восстановительных процессов и неоангиогенеза. Полученные данные об активации регенерации печеночной ткани после лазерного воздействия на зоны локализации костного мозга могут являться основой для разработки методов лечения пациентов с заболеваниями печени

Валидация опросника для оценки качества жизни пациентов с хронической приобретенной полинейропатией (Chronic Acquired Polyneuropathy – Patient Reported Index, CAP-PRI) в России

Background. Chronic inflammatory demyelinating polyneuropathy (CIDP) is the most common immune‑mediated polyneuropathy. CIDP is characterized by a long‑term progressive or recurrent course of the disease and the development of neurological deficits and disability, it is important to assess the quality of life of patients. The paper presents the results of the first and second steps of validation of the Chronic acquired polyneuropathy – Patient Reported Index (CAP‑PRI) questionnaire designed to assess quality of life in patients with immune‑mediated polyneuropathy.Aim. To develop the Russian version of the CAP‑PRI questionnaire.Materials and methods. 85 patients with CIDP (according to EAN / PNS 2021 criteria) were enrolled. At the first step we conducted linguocultural validation according to the standard protocol. Two Russian‑speaking professional translators in the field of medicine performed direct translation of the original English‑language questionnaire, and the back translation was performed by native speakers with a medical background. At the second step the psychometric parameters were evaluated.Results. The developed Russian version of the CAP‑PRI questionnaire demonstrated a high level of reliability, validity and sensitivity.Conclusion. The Russian version of the CAP‑PRI questionnaire is recommended for clinical practice and research. In addition, the relationship between improved quality of life and the reduction of neurological deficits, disability and fatigue (as assessed by the IRODS, NIS and FSS scales) has been shown.Введение. Хроническая воспалительная демиелинизирующая полинейропатия (ХВДП) – самая частая из иммуноопосредованных полинейропатий. Для ХВДП характерны многолетнее прогрессирующее или рецидивирующее течение, развитие неврологического дефицита и инвалидизации, в связи с чем важен мониторинг качества жизни пациентов. Представлены результаты 1‑го и 2‑го этапов валидации русскоязычной версии опросника Chronic Acquired Polyneuropathy – Patient Reported Index (CAP‑PRI) для оценки качества жизни у пациентов с иммуноопосредованными полинейропатиями.Цель исследования – проведение валидации опросника CAP‑PRI у пациентов с ХВДП с разработкой его русскоязычной версии.Материалы и методы. В исследование было включено 85 пациентов с ХВДП, диагностированной на основании критериев EAN / PNS 2021. На 1‑м этапе проведена лингвистическая валидация оригинальной англоязычной версии опросника согласно общепринятым рекомендациям: 2 русскоязычными профессиональными переводчиками в сфере медицины выполнен прямой перевод оригинальной англоязычной шкалы, обратный перевод осуществлен носителями языка с медицинским образованием. На 2‑м этапе валидации проводилось исследование психометрических показателей разработанного русскоязычного варианта.Результаты. Разработана русскоязычная версия опросника CAP‑PRI с высоким уровнем надежности, содержательной валидности и чувствительности.Заключение. Представленная официальная русскоязычная версия опросника для пациентов с хронической приобретенной полинейропатией (CAP‑PRI) рекомендована для отечественной клинической практики и научно‑исследовательской работы с целью оценки качества жизни пациентов. Дополнительно показана связь между улучшением качества жизни и уменьшением выраженности неврологического дефицита, степени инвалидизации и утомляемости (по результатам оценок по шкалам IRODS, NIS и FSS)

LYMPHOCYTE SUBPOPULATION PROFILE IN YOUNG MEN WITH METABOLIC SYNDROME

Metabolic syndrome is a chronic subclinical inflammation. Published data on the immune state in metabolic syndrome are inconsistent, and, moreover, the gender features of metabolic syndrome are not described in details. The purpose of the study was to determine subpopulation profile of peripheral lymphocytes in young men with metabolic syndrome, as well as in cases of combined abdominal obesity and hypertension. The study included seventy-seven men aged 20-45 years. The men were divided into four groups matched by age: Group 1 represented healthy controls; group 2 included male patients with isolated abdominal obesity; group 3 consisted of males with a combination of abdominal obesity and hypertension; group 4, males with metabolic syndrome. The major lymphocyte subpopulations were isolated and analyzed by flow cytometry, i.e. T lymphocytes, T helpers, T-cytotoxic cells, TNK-lymphocytes, NK-cells, B-cells, as well as CD3+CD25+ and CD3+HLADR+ lymphocytes. In male patients with isolated abdominal obesity, we revealed increased relative contents of T lymphocytes, and increased proportion of the cells with CD3+CD8+, CD3+CD25+ phenotypes and higher B-cell numbers. A combination of abdominal obesity with hypertension in men was characterized by decreased ratio of T-helper/T-cytotoxic lymphocytes, due to reduced relative contents of CD3+CD4+ cells and increase in CD3+CD8+ lymphocytes. The numbers of T-helper cells in this group were significantly lower than in controls and among patients with isolated abdominal obesity. The number of T-cells with CD3+HLADR+ phenotype proved to be 2-fold higher than in the group of healthy male controls