22 research outputs found
Temperature Diffusivity Measurement and Nondestructive Testing Requiring No Extensive Sample Preparation and Using Stepwise Point Heating and IR Thermography
This chapter describes a modification to the laser flash method that allows determining temperature diffusivity and nondestructive testing of materials and constructions without cutting samples of predefined geometry. Stepwise local heating of the studied object surface at a small spot around 0.1 mm radius with simultaneous high temporary-spatial resolution infrared (IR) filming of the transient temperature distribution evolution with a thermal camera provides a wide range of possibilities for material characterization and sample testing. In case of isotropic and macroscopic homogeneous materials, the resulting transient temperature distribution is radially symmetric that renders possible to improve temperature measurement accuracy by averaging many pixels of the IR images located at the same distance from the heating spot center. The temperature diffusivity measurement can be conducted either on thin plates or on massive samples. The developed emissivity independent in plain IR thermographic method and mathematical algorithms enable thermal diffusivity measurement for both cases with accuracy around a few per cent for a wide range of materials starting from refractory ceramics to well-conducting metals. To detect defects, the differential algorithm was used. Subtracting averaged radial symmetric temperature distribution from the original one for each frame makes local inhomogeneities in the sample under study clearly discernible. When applied to crack detection in plates, the technique demonstrates good sensitivity to part-through cracks located both at the visible and invisible sides of the studied object
Computer-Aided Design of Microwave-Photonics-Based RF Circuits and Systems
In the process of design, a developer of new microwave-photonics-based RF apparatuses is facing a problem of choosing appropriate software. As of today, the existing optical and optoelectronic CAD tools (OE-CAD) are not developed like CAD tools intended for modeling of RF circuits (E-CAD). On the contrary, operating at symbolic level, modern high-power microwave E-CAD tools simply and with high precision solve this problem, but there are no models of active photonic components in their libraries. To overcome this problem, we proposed and validated experimentally a new approach to model a broad class of promising analog microwave radio-electronics systems based on microwave photonics technology. This chapter reviews our known, updated, new models and simulation results using microwave-electronics off-the-shelf computer tool NI AWRDE to pursue advanced performances corresponding to the last generation of key photonics structural elements and important RF devices on their basis
Nanomechanical testing of ODS steels irradiated with 1 MeV/amu heavy ions
Heavy ion beams with high damage production rate are widely used to evaluate radiation tolerance of promising nuclear reactor materials, such as oxide dispersion strengthened (ODS) alloys, including their mechanical properties. Since typical ion projected ranges do not exceed 1 micron, nanoindentation technique is the most convenient method for examination of irradiated materials.
In present work we report data on radiation hardening of several ODS steels irradiated with 107 MeV Kr and 167 MeV Xe ions. Some samples were irradiated trough the special Al-foil filter in order to obtain the unfolding damage profile on the surface. The post-irradiation testing steels included conventional nanoindentation measurements and CSM for determination of possible size effects associated with indentation size effect as well as soft surface effect. Swift heavy ion induced changes in microstructure evolution were studied by transmission electron microscopy (TEM). It was found that hardening of the ODS steels irradiated with krypton and xenon ions of fission fragment energy for damage dose about 1 dpa level is in the range 5-25% (figure 1).
TEM examination have revealed complete amorphization of carbide and (Y,Ti) oxide particles in ferritic matrices as a result of multiple amorphous latent track overlapping. At the same time no dissolution of nano-oxide particles was observed. This implies that radiation hardening is not due to changes in morphology of nanoparticles
New hybrid materials on the basis of magnetite and magnetite-gold nanoparticles for biomedical application
During last decades magnetite nanoparticles (NPs) attract a deep interest of scientists due to their potential application in therapy and diagnostics. However, magnetite nanoparticles are toxic and non-stable in physiological conditions. To solve these problems, we decided to create two types of hybrid systems based on magnetite and gold which is inert and biocompatible: gold as a shell material (first type) and gold as separate NPs interfacially bond to magnetite NPs (second type). An additional advantage of gold is the possibility of its functionalization with a variety of sulphur-containing ligands; that is very important for drug delivery and creating of tissue-specific MRI contrast agents.
The synthesis of the first type hybrid nanoparticles was carried out as follows: magnetite nanoparticles with an average diameter of 9±2 nm were obtained by co-precipitation of iron (II, III) chlorides then they were covered with gold shell by iterative reduction of hydrogen tetrachloroaurate with hydroxylamine hydrochloride. According to the TEM, ICP MS and EDX data, final nanoparticles had an average diameter of 31±4 nm and contained iron even after hydrochloric acid treatment. However, iron signals (K-line, 7,1 keV) were not localized so we can’t speak about one single magnetic core. Described nanoparticles covered with mercapto-PEG acid were non-toxic for human prostate cancer PC-3/ LNCaP cell lines (more than 90% survived cells as compared to control) and had high R2-relaxivity rates (\u3e190 mМ-1s-1) that exceed the transverse relaxation rate of commercial MRI-contrasting agents. These nanoparticles were also used for chymotrypsin enzyme immobilization. The effect of alternating magnetic field on catalytic properties of chymotrypsin immobilized on magnetite nanoparticles, notably the slowdown of catalyzed reaction at the level of 35-40 % was found. The most probable reason for the observed effect is the change of active centers topology on the enzyme surface as a result of its deformation under applied forces.
The synthesis of the second type hybrid nanoparticles also involved two steps. Firstly, spherical gold nanoparticles with an average diameter of 9±2 nm were synthesized by the reduction of hydrogen tetrachloroaurate with oleylamine; secondly, they were used as seeds during magnetite synthesis by thermal decomposition of iron pentacarbonyl in octadecene. As a result, so-called dumbbell-like structures were obtained where magnetite (cubes with 25±6 nm diagonal) and gold nanoparticles were connected together pairwise. By HRTEM method (first time for this type of structure) an epitaxial growth of magnetite nanoparticles on gold surface with co-orientation of (111) planes was discovered. These nanoparticles were transferred into water by means of block-copolymer Pluronic F127 then loaded with anti-cancer drug doxorubicin and also PSMA-vector specific for LNCaP cell line. Obtained nanoparticles were found to have moderate toxicity for human prostate cancer cells and got into the intracellular space after 45 minutes of incubation (according to fluorescence microscopy data). These materials are also perspective from MRI point of view (R2-relaxivity rates \u3e70 mМ-1s-1).
Thereby, in this work magnetite-gold hybrid nanoparticles, which have a strong potential for biomedical application, particularly in targeted drug delivery and magnetic resonance imaging, were synthesized and characterized. That paves the way to the development of new medicine types – theranostics.
The authors knowledge financial support from Ministry of Education and Science of the Russian Federation (14.607.21.0132, RFMEFI60715X0132). This work was also supported by Grant of Ministry of Education and Science of the Russian Federation К1-2014-022, Grant of Russian Scientific Foundation 14-13-00731 and MSU development program 5.13
Towards nanomedicines of the future: Remote magneto-mechanical actuation of nanomedicines by alternating magnetic fields
The paper describes the concept of magneto-mechanical actuation of single-domain magnetic nanoparticles (MNPs) in super-low and low frequency alternating magnetic fields (AMFs) and its possible use for remote control of nanomedicines and drug delivery systems. The applications of this approach for remote actuation of drug release as well as effects on biomacromolecules, biomembranes, subcellular structures and cells are discussed in comparison to conventional strategies employing magnetic hyperthermia in a radio frequency (RF) AMF. Several quantitative models describing interaction of functionalized MNPs with single macromolecules, lipid membranes, and proteins (e.g. cell membrane receptors, ion channels) are presented. The optimal characteristics of the MNPs and an AMF for effective magneto-mechanical actuation of single molecule responses in biological and bio-inspired systems are discussed. Altogether, the described studies and phenomena offer opportunities for the development of novel therapeutics both alone and in combination with magnetic hyperthermia
Remote Actuation of Magnetic Nanoparticles For Cancer Cell Selective Treatment Through Cytoskeletal Disruption
Motion of micron and sub-micron size magnetic particles in alternating magnetic fields can activate mechanosensitive cellular functions or physically destruct cancer cells. However, such effects are usually observed with relatively large magnetic particles (>250 nm) that would be difficult if at all possible to deliver to remote sites in the body to treat disease. Here we show a completely new mechanism of selective toxicity of superparamagnetic nanoparticles (SMNP) of 7 to 8 nm in diameter to cancer cells. These particles are coated by block copolymers, which facilitates their entry into the cells and clustering in the lysosomes, where they are then magneto-mechanically actuated by remotely applied alternating current (AC) magnetic fields of very low frequency (50 Hz). Such fields and treatments are safe for surrounding tissues but produce cytoskeletal disruption and subsequent death of cancer cells while leaving healthy cells intact
Success Factors of Internet-Activism in Social Networks
Social networks are gradually becoming a space for organizing and conducting civil campaigns. Authors analyze the factors that contribute to the organization of a successful campaign in social networks. They identify social groups that are most susceptible to influence in social networks. The authors also for-mulate a methodology for assessing the involvement of citizens in a civil campaign in social networks.The paper provides the results of a survey of experts to evaluate the factors that enable to ensure the success of the civil campaign on the Internet
Success Factors of Internet-Activism in Social Networks
Social networks are gradually becoming a space for organizing and conducting civil campaigns. Authors analyze the factors that contribute to the organization of a successful campaign in social networks. They identify social groups that are most susceptible to influence in social networks. The authors also for-mulate a methodology for assessing the involvement of citizens in a civil campaign in social networks.The paper provides the results of a survey of experts to evaluate the factors that enable to ensure the success of the civil campaign on the Internet
Multiscale Mechanical Performance of Wood: From Nano- to Macro-Scale across Structure Hierarchy and Size Effects
This review describes methods and results of studying the mechanical properties of wood at all scales: from nano- to macro-scale. The connection between the mechanical properties of material and its structure at all these levels is explored. It is shown that the existing size effects in the mechanical properties of wood, in a range of the characteristic sizes of the structure of about six orders of magnitude, correspond to the empirical Hall-Petch relation. This “law” was revealed more than 60 years ago in metals and alloys and later in other materials. The nature, as well as the particular type of the size dependences in different classes of materials can vary, but the general trend, “the smaller the stronger”, remains true both for wood and for other cellulose-containing materials. The possible mechanisms of the size effects in wood are being discussed. The correlations between the mechanical and thermophysical properties of wood are described. Several examples are used to demonstrate the possibility to forecast the macromechanical properties of wood by means of contactless thermographic express methods based on measuring temperature diffusivity. The research technique for dendrochronological and dendroclimatological studies by means of the analysis of microhardness and Young’s modulus radial dependences in annual growth rings is described