Statistical Modeling in Fire-ignition Hazard Evaluation

The probabilistic approach to the evaluation of fire hazard and the effectiveness of fire-precaution measures enables a rational response to the randomness of fire outbreaks. This article employs the statistical analysis methods to elucidate the causes for the ignition of fire on a random sample of industrial buildings in the Republic of Slovenia. The analyses are based on the Structural Equation Modeling (SEM), which is a well-established and important statistical analysis technique in the fields of biology, psychology and medicine, but hitherto rarely applied in safety research. The results of the study demonstrate that for the analyzed random sample of industrial buildings the frequency of fire outbreaks statistically significantly depends only on the presence and the probability of exposition to the heat sources (flames, sparks, and hot surfaces), but does not significantly depend on the available quantity of flammable materials within the industrial structure

Head Direction Cells and Episodic Spatial Information in Rats without a Hippocampus

To successfully navigate through the environment animals rely on information concerning their directional heading and location. Many cells within the postsubiculum and anterior thalamus discharge as a function of the animal’s head direction (HD), while many cells in the hippocampus discharge in relation to the animal’s location. We placed lesions in the hippocampus and recorded from HD cells in the postsubiculum and anterior thalamus. Lesions of the hippocampus did not disrupt the HD cell signal in either brain area, indicating that the HD cell signal must be generated by structures external to the hippocampus. In addition, each cell’s preferred firing direction remained stable across days when the lesioned animal was placed into a novel environment. This stability appeared to weaken after several weeks of nonexposure to the new enclosure for two out of five animals, and subsequently recorded cells from these two animals established a new angular relationship between the familiar and novel environments. Our results suggest that extra-hippocampal structures are capable of creating and maintaining a novel representation of the animal’s environmental context. This representation shares features in common with mnemonic processes involving episodic memory that until now were assumed to require an intact hippocampus

Viscoelastic Properties of Cardiovascular Tissues

The aims of this chapter are to review the current state of knowledge regarding the viscoelastic behavior of cardiovascular tissues. We begin with a brief, general discussion of measurement and modeling of cardiovascular tissue viscoelasticity. We then review known viscoelastic behavior of arteries, veins, capillaries, blood components, the heart, and lymphatics. For each tissue type, we highlight tissue-specific measurement methods, the cellular and extracellular components responsible for tissue viscoelasticity, and the clinical implications of energy loss due to viscoelasticity. We conclude with a summary and suggestions for future research

Analysis of Modified Starch Adsorption Kinetics on Cellulose Fibers via the Modified Langmuir Adsorption Theory

The kinetics of starch adsorption on cellulose fibers is one of the most important criteria regarding the efficient application of papermaking additives due to the continuous nature of paper production and the concomitant need to determine optimum residence times. This study presents an analysis of the kinetics of modified starch adsorption onto cellulose fibers via the application of the modified Langmuir adsorption theory (i.e. the collision theory). A model based on this theory was used to describe the kinetics of starch binding, and to obtain the adsorption rate constant under different process conditions, which closely correspond to the conditions commonly encountered in industrial production of paper and board. The model predictions were then correlated with the experimental data. The adsorption of modified starch was found to increase by increasing the fiber consistency, shear forces (via stirring frequency) and the refining degree of fibers. The results also demonstrate that, at least in the studied range of process variables, the modified Langmuir adsorption theory can be applied to describe the adsorption kinetics of modified starch on cellulose fibers

Studying patterns of use of transport modes through data mining - Application to U.S. national household travel survey data set

Data collection activities related to travel require large amounts of financial and human resources to be conducted successfully. When available resources are scarce, the information hidden in these data sets needs to be exploited, both to increase their added value and to gain support among decision makers not to discontinue such efforts. This study assessed the use of a data mining technique, association analysis, to understand better the patterns of mode use from the 2009 U.S. National Household Travel Survey. Only variables related to self-reported levels of use of the different transportation means are considered, along with those useful to the socioeconomic characterization of the respondents. Association rules potentially showed a substitution effect between cars and public transportation, in economic terms but such an effect was not observed between public transportation and nonmotorized modes (e.g., bicycling and walking). This effect was a policy-relevant finding, because transit marketing should be targeted to car drivers rather than to bikers or walkers for real improvement in the environmental performance of any transportation system. Given the competitive advantage of private modes extensively discussed in the literature, modal diversion from car to transit is seldom observed in practice. However, after such a factor was controlled, the results suggest that modal diversion should mainly occur from cars to transit rather than from nonmotorized modes to transi

Severe drug-induced gingival enlargement and periodontitis: A case series with clinical presentation and management

Gingival enlargement (GE) is a condition in which the size of the gingiva increases in response to inflammation, systemic disease, or certain medications including anticonvulsants, calcium-channel blockers, and immunosuppressants. This report describes the management of two cases involving severe gingival enlargement related to the use of an anti-hypertensive calcium-channel blocker and an immunosuppressant. Besides taking amlodipine, one patient had undergone a heart transplantation seven years prior and has been taking two immunosuppressant drugs, mycophenolate and tacrolimus. The extent of the destruction of periodontal support, aggravated by gingival enlargement, resulted in extensive tooth loss. Periodontitis and gingival enlargement exacerbate and accelerate one another and can result in loss of the entire dentition, severely affecting function and esthetics. The pharmacologic etiology sometimes cannot be altered and the patient has to be carefully managed and maintained with periodontal therapy. Physicians and dentists should be aware of these medications and be able to identify early changes in the oral cavity and to prevent, diagnose, and successfully manage the unwanted side effects of these drugs in patients

Light dark forces at flavor factories

SuperB experiment could represent an ideal environment to test a new U (1) symmetry related to light dark forces candidates. A promising discovery channel is represented by the resonant production of a boson U, followed by its decay into lepton pairs. Beyond approximations adopted in the literature, an exact tree level calculation of the radiative processes $e+ e- \rightarrow \gamma, U \rightarrow \mu^+ \mu^- \gamma, e^+ e^- \gamma$ and corresponding QED backgrounds is performed, including also the most important higher-order corrections. The calculation is implemented in a release of the generator BabaYaga@NLO useful for data analysis and interpretation. The distinct features of U boson production are shown and the statistical significance is analysed

Antimicrobial Resistance and Virulence Genes in Enterococcus faecium and Enterococcus faecalis from Humans and Retail Red Meat

The emergence of antimicrobial-resistant and virulent enterococci is a major public health concern. While enterococci are commonly found in food of animal origin, the knowledge on their zoonotic potential is limited. The aim of this study was to determine and compare the antimicrobial susceptibility and virulence traits of Enterococcus faecalis and Enterococcus faecium isolates from human clinical specimens and retail red meat in Slovenia. A total of 242 isolates were investigated: 101 from humans (71 E. faecalis, 30 E. faecium) and 141 from fresh beef and pork (120 E. faecalis, 21 E. faecium). The susceptibility to 12 antimicrobials was tested using a broth microdilution method, and the presence of seven common virulence genes was investigated using PCR. In both species, the distribution of several resistance phenotypes and virulence genes was disparate for isolates of different origin. All isolates were susceptible to daptomycin, linezolid, teicoplanin, and vancomycin. In both species, the susceptibility to antimicrobials was strongly associated with a food origin and the multidrug resistance, observed in 29.6% of E. faecalis and 73.3% E. faecium clinical isolates, with a clinical origin (Fisher's exact test). Among meat isolates, in total 66.0% of E. faecalis and E. faecium isolates were susceptible to all antimicrobials tested and 32.6% were resistant to either one or two antimicrobials. In E. faecalis, several virulence genes were significantly associated with a clinical origin; the most common (31.0%) gene pattern included all the tested genes except hyl. In meat isolates, the virulence genes were detected in E. faecalis only and the most common pattern included ace, efaA, and gelE (32.5%), of which gelE showed a statistically significant association with a clinical origin. These results emphasize the importance of E. faecalis in red meat as a reservoir of virulence genes involved in its persistence and human infections with reported severe outcomes